Skip to main content
SpringerLink
Log in

Fabrication and fluorescence properties of multilayered core–shell particles composed of quantum dot, gadolinium compound, and silica

  • Published:
Journal of Materials Science Aims and scope Submit manuscript

Abstract

A preparation method for multilayered quantum dot/silica/gadolinium compound/silica (QD/Si/Gd/Si) core–shell particles is proposed. Silica (Si)-coated quantum dot (QD/Si) core–shell particles were prepared by a Stöber method at room temperature in water/ethanol solution with TEOS and NaOH in the presence of QD nanoparticles. Succeeding gadolinium compound (Gd)-coating of the QD/Si core–shell particles was performed by a homogeneous precipitation method using Gd(NO3)3, urea, and polyvinylpyrrolidone in the presence of the QD/Si particles, which resulted in production of multilayered QD/silica/gadolinium compound (QD/Si/Gd) core–shell particles. For Si-coating of the QD/Si/Gd particles, the Stöber method was performed at room temperature in water/ethanol solution with TEOS and NaOH in the presence of the QD/Si/Gd particles. Consequently, Si-coated QD/Si/Gd, i.e., multilayered QD/Si/Gd/Si, core–shell particles were obtained. The QD/Si/Gd/Si particles revealed strong fluorescence, which was almost comparable to the QD particles with no shells. These particles are expected to be harmless to living bodies, and have dual functions of magnetic resonance imaging and fluorescence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Ratzinger G, Agrawal P, Körner W, Lonkai J, Sanders HMHF, Terreno E, Wirth M, Strijkers GJ, Nicolay K, Gabor F (2010) Biomaterials 31:8716

    Article  CAS  Google Scholar 

  2. Shiraishi K, Kawano K, Maitani Y, Yokoyama M (2010) J Control Release 148:160

    Article  CAS  Google Scholar 

  3. Nwe K, Bernardo M, Regino CAS, Williams M, Brechbiel MW (2010) Bioorg Med Chem 18:5925

    Article  CAS  Google Scholar 

  4. Bussi S, Fouillet X, Morisetti A (2007) Exp Toxicol Pathol 58:323

    Article  CAS  Google Scholar 

  5. Gräfe JL, McNeill FE, Byun SH, Chettle DR, Noseworthy MD (2011) Appl Radiat Isot 69:105

    Article  Google Scholar 

  6. Liu S, Zhang Z, Wang Y, Wang F, Han MY (2005) Talanta 67:456

    Article  CAS  Google Scholar 

  7. Heitsch AT, Smith DK, Patel RN, Ress D, Korgel BA (2008) J Solid State Chem 181:1590

    Article  CAS  Google Scholar 

  8. Lu P, Zhang JL, Liu YL, Sun DH, Liu GX, Hong GY, Ni JZ (2010) Talanta 82:450

    Article  CAS  Google Scholar 

  9. Wang Y, Bai X, Liu T, Dong B, Xu L, Liu Q, Song H (2010) J Solid State Chem 183:2779

    Article  CAS  Google Scholar 

  10. Wang L, Neoh KG, Kang ET, Shuter B (2011) Biomaterials 32:2166

    Article  CAS  Google Scholar 

  11. Liu Z, Liu P, Liu C, Yao K, Ning Q, Xi D, Xu H (2007) J Mater Sci 42:5147. doi:10.1007/s10853-006-1284-0

    Article  CAS  Google Scholar 

  12. Ghica C, Ionita P (2007) J Mater Sci 42:10058. doi:10.1007/s10853-007-1980-4

    Article  CAS  Google Scholar 

  13. Wang X, Ji H, Zhang X, Zhang H, Yang X (2010) J Mater Sci 45:3981. doi:10.1007/s10853-010-4470-z

    Article  CAS  Google Scholar 

  14. Liu G, Wu H, Zheng H, Tang L, Hu H, Yang H, Yang S (2011) J Mater Sci 46:5959. doi:10.1007/s10853-011-5551-3

    Article  CAS  Google Scholar 

  15. Kobayashi Y, Horie M, Konno M, Rodríguez-González B, Liz-Marzán LM (2003) J Phys Chem B 107:7420

    Article  CAS  Google Scholar 

  16. Mine E, Yamada A, Kobayashi Y, Konno M, Liz-Marzán LM (2003) J Colloid Interface Sci 264:385

    Article  CAS  Google Scholar 

  17. Kobayashi Y, Misawa K, Kobayashi M, Takeda M, Konno M, Satake M, Kawazoe Y, Ohuchi N, Kasuya A (2004) Colloids Surf A 242:47

    Article  CAS  Google Scholar 

  18. Kobayashi Y, Misawa K, Takeda M, Kobayashi M, Satake M, Kawazoe Y, Ohuchi N, Kasuya A, Konno M (2004) Colloids Surf A 251:197

    Article  CAS  Google Scholar 

  19. Kobayashi Y, Katakami H, Mine E, Nagao D, Konno M, Liz-Marzán LM (2005) J Colloid Interface Sci 283:392

    Article  CAS  Google Scholar 

  20. Mine E, Hirose M, Kubo M, Kobayashi Y, Nagao D, Konno M (2006) J Sol-Gel Sci Technol 38:91

    Article  CAS  Google Scholar 

  21. Kobayashi Y, Horie M, Nagao D, Ando Y, Miyazaki T, Konno M (2006) Mater Lett 60:2046

    Article  CAS  Google Scholar 

  22. Kobayashi Y, Misawa K, Takeda M, Ohuchi N, Kasuya A, Konno M (2007) Adv Mater Res 29–30:191

    Article  Google Scholar 

  23. Kobayashi Y, Misawa K, Takeda M, Ohuchi N, Kasuya A, Konno M (2008) Mater Res Soc Symp Proc 1074E:I10

    Google Scholar 

  24. Kobayashi Y, Shimizu N, Misawa K, Takeda M, Ohuchi N, Kasuya A, Konno M (2008) Surf Eng 24:248

    Article  CAS  Google Scholar 

  25. Kobayashi Y, Sakuraba T (2008) Colloids Surf A 317:756

    Article  CAS  Google Scholar 

  26. Kobayashi Y, Kakinuma H, Nagao D, Ando Y, Miyazaki T, Konno M (2008) J Sol-Gel Sci Technol 47:16

    Article  CAS  Google Scholar 

  27. Kobayashi Y, Kakinuma H, Nagao D, Ando Y, Miyazaki T, Konno M (2009) J Nanoparticle Res 11:1787

    Article  CAS  Google Scholar 

  28. Kobayashi Y, Nozawa T, Nakagawa T, Gonda K, Takeda M, Ohuchi N, Kasuya A (2010) J Sol-Gel Sci Technol 55:79

    Article  CAS  Google Scholar 

  29. Kobayashi Y, Minato M, Ihara K, Sato M, Suzuki N, Takeda M, Ohuchi N, Kasuya A (2010) J Nanosci Nanotechnol 10:7758

    Article  CAS  Google Scholar 

  30. Kobayashi Y, Nozawa T, Takeda M, Ohuchi N, Kasuya A (2010) J Chem Eng Jpn 43:490

    Article  CAS  Google Scholar 

  31. Kobayashi Y, Inose H, Nakagawa T, Gonda K, Takeda M, Ohuchi N, Kasuya A (2011) J Colloid Interface Sci 358:329

    Article  CAS  Google Scholar 

  32. Kobayashi H, Hama Y, Koyama Y, Barrett T, Regino CAS, Urano Y, Choyke PL (2007) Nano Lett 7:1711

    Article  CAS  Google Scholar 

  33. Xie J, Lee S, Chen X (2010) Adv Drug Deliv Rev 62:1064

    Article  CAS  Google Scholar 

  34. Biju V, Mundayoor S, Omkumar RV, Anas A, Ishikawa M (2010) Biotechnol Adv 28:199

    Article  CAS  Google Scholar 

  35. Brus LE (1984) J Chem Phys 80:4403

    Article  CAS  Google Scholar 

  36. Vuu K, Xie J, McDonald MA, Bernardo M, Hunter F, Zhang Y, Li K, Bednarski M, Guccione S (2005) Bioconj Chem 16:995

    Article  CAS  Google Scholar 

  37. Lin YS, Wu SH, Hung Y, Chou YH, Chang C, Lin ML, Tsai CP, Mou CY (2006) Chem Mater 18:5170

    Article  CAS  Google Scholar 

  38. Guo J, Yang W, Deng Y, Wang C, Fu S (2005) Small 1:737

    Article  CAS  Google Scholar 

  39. Selvan ST, Patra PK, Ang CY, Ying JY (2007) Angew Chem Int Ed 46:2448

    Article  CAS  Google Scholar 

  40. Dubus S, Gravel JF, Drogoff BL, Nobert P, Veres T, Boudreau D (2006) Anal Chem 78:4457

    Article  CAS  Google Scholar 

  41. Guo J, Yang W, Wang C, He J, Chen J (2006) Chem Mater 18:5554

    Article  CAS  Google Scholar 

  42. Salgueiriño-Maceira V, Correa-Duarte MA (2007) Adv Mater 19:4131

    Article  Google Scholar 

  43. Stöber W, Fink A, Bohn E (1968) J Colloid Interface Sci 26:62

    Article  Google Scholar 

  44. Shimura N, Ogawa M (2007) J Mater Sci 42:5299. doi:10.1007/s10853-007-1771-y

    Article  CAS  Google Scholar 

  45. Lu BW, Endo A, Inagi Y, Harada A, Ohmori T (2009) J Mater Sci 44:6463. doi:10.1007/s10853-009-3627-0

    Article  CAS  Google Scholar 

  46. Mitchell SC, Zhang AQ (2001) Clin Chim Acta 312:107

    Article  CAS  Google Scholar 

  47. Benigni R, Passerini L (2002) Mutat Res 511:191

    Article  CAS  Google Scholar 

  48. Gonda K, Watanabe TM, Ohuchi N, Higuchi H (2010) J Biol Chem 285:2750

    Article  CAS  Google Scholar 

  49. Hikage M, Gonda K, Takeda M, Kamei T, Kobayashi M, Kumasaka M, Watanabe M, Satomi S, Ohuchi N (2010) Nanotechnology 21:185103

    Article  Google Scholar 

  50. Singh G, Song L (2007) J Membr Sci 303:112

    Article  CAS  Google Scholar 

  51. Yilmaz H, Sato K, Watari K (2007) J Colloid Interface Sci 307:116

    Article  CAS  Google Scholar 

  52. Li SZ, Xu RK (2008) Colloids Surf A 326:157

    Article  CAS  Google Scholar 

  53. Morimoto H, Minato M, Nakagawa T, Sato M, Kobayashi Y, Gonda K, Takeda M, Ohuchi N, Suzuki N (2011) J Sol-Gel Sci Technol 59:650

    Article  CAS  Google Scholar 

  54. Kobayashi Y, Imai J, Nagao D, Takeda M, Ohuchi N, Kasuya A, Konno M (2007) Colloids Surf A 308:14

    Article  CAS  Google Scholar 

Download references

Acknowledgement

We express our thanks to Prof. T. Noguchi in College of Science of Ibaraki University, Japan for his help in TEM observation.

Author information

Authors and Affiliations

  1. Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, 4-12-1 Naka-narusawa-cho, Hitachi, Ibaraki, 316-8511, Japan

    Yoshio Kobayashi & Takuya Nozawa

  2. Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Tomohiko Nakagawa, Kohsuke Gonda, Motohiro Takeda & Noriaki Ohuchi

  3. Department of Surgical Oncology, Graduate School of Medicine, Tohoku University, Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan

    Noriaki Ohuchi

Authors
  1. Yoshio Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takuya Nozawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tomohiko Nakagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kohsuke Gonda
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Motohiro Takeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Noriaki Ohuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yoshio Kobayashi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kobayashi, Y., Nozawa, T., Nakagawa, T. et al. Fabrication and fluorescence properties of multilayered core–shell particles composed of quantum dot, gadolinium compound, and silica. J Mater Sci 47, 1852–1859 (2012). https://doi.org/10.1007/s10853-011-5972-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10853-011-5972-z

Keywords

Search

Navigation