Polymer grafting onto magnetite nanoparticles by “click” reaction


In this article, we described click chemistry methodology for the incorporation of biocompatible polymer chains to Magnetite nanoparticles (NPs). We used a reduction co-precipitation method to obtain Fe3O4 particles in aqueous solution. As a next step, magnetic NPs surface were modified by a silanization reaction with (3-bromopropyl)trimethoxysilane in order to introduce bromine groups on the particles surface which were converted to azide groups by the reaction with sodium azide. Acetylene functionalized poly(ethylene glycol) (a-PEG) and poly(ε-caprolactone) (a-PCL) were synthesized and grafted onto the surface of azide functionalized NPs via “click” reaction to obtain magnetic NPs. Success of the different functionalization processes at different stages was studied using Fourier Transform infrared spectroscopy (FTIR). The morphologies of magnetic NPs were further investigated by transmission electron microscopy (TEM). The magnetization and superparamagnetic behavior of naked Fe3O4 NPs and coated NPs at room temperature was investigated by the measurement of hysteresis curves using a Vibrating Sample Magnetometer (VSM).

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  1. 1.

    Purushotan S, Chang PEJ, Rumpel H, Kee IHC, Ng NTH, Chow PKH, Tan CK, Ramanujan RV (2009) Nanotechnology 20:305101

    Article  Google Scholar 

  2. 2.

    Gong P, Yu J, Sun H, Hong J, Zhao D, Xu D, Yao S (2006) J Apply Polym Sci 101:1283

    Article  CAS  Google Scholar 

  3. 3.

    Dilnawaz F, Singh A, Mohanty C, Sahoo SK (2010) Biomaterials 31:3694

    Article  CAS  Google Scholar 

  4. 4.

    Bicho A, Pec IN, Roque ACA, Cardoso MM (2010) Int J Pharm 399:80

    Article  CAS  Google Scholar 

  5. 5.

    Guanhua G, Rongrong S, Wenqing Q, Youguo S, Guofu X, Guanzhou Q, Xiaohe L (2010) J Mater Sci 45:3483. doi:10.1007/s10853-010-4378-7

    Article  Google Scholar 

  6. 6.

    Zhang LY, Zhu XY, Sun HW, Chi GR, Xu JX, Sun YL (2010) Curr Apl Phys I 10:828

    Article  Google Scholar 

  7. 7.

    Bourlinos AB, Bakandritsos A, Georgakilas V, Tzitzios V, Petridis D (2006) J Mater Sci 41:5250. doi:10.1007/s10853-006-0041-8

    Article  CAS  Google Scholar 

  8. 8.

    Lee J, Lee Y, Youn LK, Na HB, Yu T, Kim H, Lee SM, Koo YM, Kwak JH, Park HG, Chang HN, Hwang M, Park JG, Kim J, Hyeon T (2998) Small 1:143

    Google Scholar 

  9. 9.

    Arias JL, Reddy H, Couvreur P (2008) Langmuir 24:7512

    Article  CAS  Google Scholar 

  10. 10.

    Sonvico F, Dubernet C, Colombo P, Couvreur P (2005) Curr Pharm Des 11:2091

    Article  CAS  Google Scholar 

  11. 11.

    Alexiou C, Schmid RJ, Jurgons R, Kremer M, Wanner G, Bergemann C, Huenges E, Nawroth T, Arnold W, Parak FG (2006) Eur Biophys J 35:446

    Article  CAS  Google Scholar 

  12. 12.

    Arruebo M, Fernandez-Pacheco R, Ibarra MR, Santamaria J (2007) Nanotoday 2:22

    Google Scholar 

  13. 13.

    Prijic S, Sersa G (2011) Radiol Oncol 45:1

    Article  CAS  Google Scholar 

  14. 14.

    Sun HW, Zhang LY, Zhu XJ, Kong CY, Zhang CL, Yao SD (2009) Sci China Ser B 52:69

    Article  CAS  Google Scholar 

  15. 15.

    Darwish MSA, Peuker U, Kunz U, Turek T (2011) J Mater Sci 46:2123. doi:10.1007/s10853-010-5048-5

    Article  CAS  Google Scholar 

  16. 16.

    Sun C, Lee JSH, Zhang M (2008) Adv Drug Delivery Rev 60:1252

    Article  CAS  Google Scholar 

  17. 17.

    Portet D, Denizot B, Rump E, Lejeune JJ, Jallet P (2001) J Colloid Interf Sci 238:37

    Article  CAS  Google Scholar 

  18. 18.

    Yang L, Peng XH, Wang YA, Wang X, Cao Z, Ni C, Karna P, Zhang X, Wood WC, Gao X, Nie S, Mao H (2009) Clin Cancer Res 15:4722

    Article  CAS  Google Scholar 

  19. 19.

    Neuberger T, Schopf B, Hofmann H, Hofmann M, von Rechenberg B (2005) J Magn Magn Mater 293:483

    Article  CAS  Google Scholar 

  20. 20.

    Kappiyoor R, Liangruksa M, Ganguly R, Puril IK (2010) J Appl Phys 108:4702

    Article  Google Scholar 

  21. 21.

    Frickel N, Messing R, Gelbrich T, Schmidt AM (2010) Langmuir 26:2839

    Article  CAS  Google Scholar 

  22. 22.

    Liu TY, Liu K, Liu DM, Chen SY, Chen IW (2009) Adv Funct Mater 19:616

    Article  CAS  Google Scholar 

  23. 23.

    Nan A, Turcu R, Craciunescu I, Pana O, Scharf H, Liebscher J (2009) J Polym Sci Part A 47:5397

    Article  CAS  Google Scholar 

  24. 24.

    Johnson JA, Finn MG, Koberstein JT, Turro NJ (2008) Macromol Rapid Commun 29:1052–1072

    Article  CAS  Google Scholar 

  25. 25.

    Durmaz YY, Sangermano M, Yagci Y (2010) J Polym Sci A 48:2862

    Article  CAS  Google Scholar 

  26. 26.

    Von Maltzahn G, Ren Y, Park JH, Min DH, Kotamraju VR, Jayakumar J, Fogal V, Sailor MJ, Erkki Ruoslahti SN (2008) Bioconjugate Chem 19:1570

    Article  Google Scholar 

  27. 27.

    Li LY, He WD, Li WT, Zhang KR, Pan TT, Ding ZL, Zhang BY (2010) J Polym Sci A 48:5018

    Article  CAS  Google Scholar 

  28. 28.

    Achatz DE, Heiligtag FJ, Li X, Link M, Wolfbeis OS (2010) Sens Actuators B 150:211

    Article  Google Scholar 

  29. 29.

    Amici J, Celasco E, Allia P, Tiberto P, Sangermano M (2011) Macromol Chem Phys 212:411

    Article  CAS  Google Scholar 

  30. 30.

    Zhiya M, Huizhou L (2007) Chin Partic 5:1

    Article  Google Scholar 

  31. 31.

    Stella B, Arpicco S, Peracchia MT, Desmaele D, Hoebeke J, Renoir M, D’Angelo J, Cattel L, Couvreur P (2000) J Pharm Sci 89:1452

    Article  CAS  Google Scholar 

  32. 32.

    Zablotskaya A, Segal I, Maiorov M, Zablotsky D, Mishnev A, Lukevics E, Shestakova I, Domracheva I (2007) J Magn Magn Mater 311:135

    Article  CAS  Google Scholar 

  33. 33.

    Mondini S, Cenedese S, Marinoni G, Molteni G, Santo N, Bianchi CL, Ponti A (2008) J Coll Interf Sci 322:173

    Article  CAS  Google Scholar 

  34. 34.

    Hyeon T (2003) Chem Commun 8:927

    Article  Google Scholar 

  35. 35.

    Lee Y, Lee J, Jin Bae C, Park J, Noh H, Park J, Hyeon T (2005) Adv Funct Mater 15:503

    Article  CAS  Google Scholar 

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Correspondence to M. Sangermano.

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Amici, J., Kahveci, M.U., Allia, P. et al. Polymer grafting onto magnetite nanoparticles by “click” reaction. J Mater Sci 47, 412–419 (2012). https://doi.org/10.1007/s10853-011-5814-z

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  • Magnetite
  • Magnetite Nanoparticles
  • Trimethoxysilane
  • Fe3O4 Particle
  • Azide Group