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In vitro degradation and cell attachment of a PLGA coated biodegradable Mg–6Zn based alloy

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Abstract

Currently available engineering magnesium alloys have several critical concerns if they are about to be used as biomaterials, particularly the concern about the toxicity of the common alloying elements such as aluminum and rare earth (RE). There is an increasing demand to develop new magnesium alloys that do not contain any toxic elements. It is also desirable, yet challenging, to develop such a material that has a controllable degradation rate in the human fluid environment. This paper presents mechanical properties, degradation, and in vitro cell attachment of a newly developed Mg–6Zn magnesium alloy. The alloy demonstrated comparable mechanical properties with typical engineering magnesium alloys. However, the bare alloy did not show an acceptable corrosion (degradation) rate. Application of a polymeric PLGA or poly(lactide-co-glycolide) coating significantly decreased the degradation rate. The results obtained from cell attachment experiments indicated that the mouse osteoblast-like MC3T3 cells could develop enhanced confluence on and interactions with the coated samples.

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Acknowledgements

The authors would like to acknowledge the financial support from the National Natural Science Foundation of China (No. 30772182 and No. 30901422), the Shanghai Jiao Tong University Interdiscipline Research Grant (No. YG2009MS53) and the “863” High-tech Programs of China (No. 2009AA03Z424). The useful and constructive comments from the reviewers are acknowledged. PC would also like to acknowledge the financial support from the Foundation of Research Science and Technology (FRST), New Zealand.

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Authors and Affiliations

  1. School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, People’s Republic of China

    J. N. Li, X. N. Zhang & S. X. Zhang

  2. Department of Chemical and Materials Engineering, the University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand

    P. Cao

  3. Institute of Powder Metallurgy, Central South University, Changsha, 410083, People’s Republic of China

    Y. H. He

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  1. J. N. Li
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  2. P. Cao
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  3. X. N. Zhang
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  4. S. X. Zhang
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Correspondence to P. Cao or X. N. Zhang.

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Li, J.N., Cao, P., Zhang, X.N. et al. In vitro degradation and cell attachment of a PLGA coated biodegradable Mg–6Zn based alloy. J Mater Sci 45, 6038–6045 (2010). https://doi.org/10.1007/s10853-010-4688-9

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  • DOI: https://doi.org/10.1007/s10853-010-4688-9

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