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Preparation and properties of a novel thermo-responsive poly(N-isopropylacrylamide) hydrogel containing glycyrrhetinic acid

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Abstract

A novel thermo-responsive poly(N-isopropylacrylamide) (PNIPAAm) hydrogel containing glycyrrhetinic acid(GA) was synthesized by free radical copolymerization. The structure of the product was confirmed by FT-IR and 1H-NMR spectra. The temperature responsibility and swelling properties of the copolymerized hydrogel were investigated by differential scanning calorimetry (DSC) and gravimetric methods. The results indicated that GA-incorporated hydrogel was still temperature responsive and the swelling ratio decreased with the increasing of temperature. The lower critical solution temperature (LCST) of GA-incorporated hydrogel and poly(N-isopropylacrylamide) hydrogel was 30.00 °C and 31.21 °C, respectively, in distilled water. However, these two values were shifted to 28.22 °C and 29.16 °C in cell culture media. The novel hydrogel also exhibited reversible temperature responsibility. Deswelling kinetics indicated that the copolymerized hydrogel deswelled more rapidly than poly(N-isopropylacrylamide) hydrogel. Since GA has specific binding capacity to asialoglycoprotein receptors on the membrane of hepatocyte, this novel hydrogel with GA could be expected as good candidate for hepatic cell culture.

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Acknowledgements

This work was supported by National Science Foundation (Grant No. 20574051) and Doctoral Foundation of Ministry of Education (Grant No. 20050058001).

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Authors and Affiliations

  1. Tianjin Key Laboratory of Fiber Modification and Functional Fiber, School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin, 300160, China

    Xiaoling He, Shen Yu, YouYu Dong & Li Chen

  2. School of Environment and Chemical Engineering, Tianjin Polytechnic University, Tianjin, 300160, China

    Xiaoling He & Fanyong Yan

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  1. Xiaoling He
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  2. Shen Yu
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  3. YouYu Dong
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  4. Fanyong Yan
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  5. Li Chen
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Correspondence to Li Chen.

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He, X., Yu, S., Dong, Y. et al. Preparation and properties of a novel thermo-responsive poly(N-isopropylacrylamide) hydrogel containing glycyrrhetinic acid. J Mater Sci 44, 4078–4086 (2009). https://doi.org/10.1007/s10853-009-3588-3

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  • DOI: https://doi.org/10.1007/s10853-009-3588-3

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