Abstract
This article reviews current work on the strength and toughness of bone, its mechanisms of fracture and its ability to repair and adapt its structure. These properties are affected at all size levels, from the nanostructure of collagen molecules and mineral crystals, through the microstructure of osteons and trabeculae, up to the macroscopic shape and density variations that occur at the level of a whole bone.
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Galileo G (1638) Dialogues concerning the two new sciences. Elzevir, Leyden, The Netherlands
Gray H (1959) Anatomy of the human body. Lee and Febiger, Philadelphia, USA
Alexander RM (1984) J Theo Biol 109:621
Martin RB (2003) J Theo Biol 220:271
Pauwels F(1980) Biomechanics of the Locomotor Apparatus. Berlin, Springer Verlag
Currey JD, Alexander RM (1985) J Zool Lon A 206:453
Huiskes R (1988) In: Fitzgerald R (ed) Non-cemented total hip arthroplasty, Raven Press, New York, pp 283–302
Prendergast PJ, Taylor D (1994) J Biomech 27:1067
Huiskes R, Rulmerman R, Van Lenthe GH, Janssen JD (2000) Nature 405:704
Taylor D (2000) J Theo Biol 206:299
Taylor D, Casolari E, Bignardi C (2004) J Orthopaed Res 22:487
Lakes RS, Nakamura S, Behiri JC, Bonfield W (1990) J Biomech 23:967
Seltzer KL, Stover SM, Taylor KT, Willits NH (1996) Veter Surg 25:371
Nalla RK, Kruzic JJ, Kinney JH, Ritchie RO (2004) Bone 35:1240
Malik CL, Stover SM, Martin RB, Gibeling JC (2003) J Biomech 36:191
Nalla RK, Kruzic JJ, Kinney JH, Ritchie RO (2005) Biomaterials 26:217
Bazant ZP (2004) Mater Struct 37:1
Taylor D (2004) Eng Frac Mech 71:2407
Nalla RK, Kinney JH, Ritchie RO (2003) Nat Mater 2:164
Vashishth D, Tanner KE, Bonfield W (2003) J Biomech 36:121
Yeni YN, Fyhrie DP (2003) J Biomech 36:1343
Natali AN, Meroi EA (1989) J Biomed Eng 11:266
Tanabe Y (1999) In: Takahashi HE (ed) Mechanical Loading of Bones and Joints. Springer-Verlag, Tokyo, Japan
Boyde A (2003) J Anatomy 203:173
Hazenberg JG, Taylor D, Lee TC (2006) Biomaterials 27:2114
Nalla RK, Kruzic JJ, Kinney JH, Ritchie RO (2005) Biomaterials 26:2183
O’Brien FJ, Taylor D, Lee TC (2005) J Orthopaed Res 23:475
Akkus O, Rimnac CM (2001) J Biomech 34:757
Frost HM (1960) Henry Ford Hosp Med Bull 8:25
O’Brien F, Taylor D, Lee TC (2002) J Biomech 35:523
O’Brien F, Taylor D, Lee TC (2000) J Anatomy 197:413
Qiu S, Rao DS, Fyhrie DP, Palnitkar S, Parfitt AM (2005) Bone 37:10
Frank JD, Ryan M, Kalscheur VL, Ruaux-Mason CP, Hozak RR, Muir P (2002) Bone 30:201
Fazzalari NL, Forwood MR, Smith K, Manthey BA, Herreen P (1998) Bone 22:381
Muir P, McCarthy J, Radtke CL, Markel MD, Santschi EM, Scollay MC, Kalscheur VL (2006) Bone 38:342
Frost HM (1969) Calci Tissue Res 3:211
Burr DB (2002) Bone 30:2
Burr DB, Martin B (1993) J Biomech 26:613
Lee TC, Staines A, Taylor D (2002) J Anatomy 201:437
Colopy SA, Benz-Dean J, Barrett JG, Sample SJ, Lu Y, Danova NA, Kalscheur VL, Vanderby J, Markel MD, Muir P (2004) Bone 35:881
Burger EH, Klein-Nulend J, Smit TH (2003) J Biomech 36:1453
Klein-Nulend J, Bacabac RG, Mullender MG (2005) Pathologie Biologie 53:576–580
Hazenberg JG, Freeley M, Foran E, Lee TC, Taylor D (2006) J Biomech (In Press)
Verborgt O, Gibson GJ, Schaffler MB (2000) J Bone Miner Res 15:60
Bentolila V, Boyce TM, Fyhrie DP, Drumb R, Skerry TM, Schaffler MB (1998) Bone 23:275
Martin B (1995) J Orthopaed Res 13:309
Hazelwood SJ, Bruce Martin R, Rashid MM, Rodrigo JJ (2001) J Biomech 34:299
Taylor D, Lee TC (2003) J Anatomy 203:203
Nyman JS, Reyes M, Wang X (2005) Micron 36:566
Ascenzi A, Baschieri P, Benvenuti A (1990) J Biomech 23:763
Vashishth D, Koontz J, Qiu SJ, Lundin-Cannon D, Yeni YN, Schaffler MB, Fyhrie DP (2000) Bone 26:147
Nyman JS, Roy A, Shen X, Acuna RL, Tyler JH, Wang X (2006) J Biomech 39:931
Wang X, Xiaoe LI, Shen X, Agrawal CM (2003) Ann Biomed Eng 31:1365
Zioupos P, Currey JD, Hamer AJ (1999) J Biomed Mater Res 45:108
Eyre DR, Dickson IR, Van Ness K (1988) Biochem J 252:495
Nalla RK, Kruzic JJ, Kinney JH, Balooch M, Ager III JW, Ritchie RO (2006) Mater Sci Eng C 26:1251
Knott L, Whitehead CC, Fleming RH, Bailey AJ (1995) Biochem J 310:1045
Akkus O, Rimnac CM (2001) J Orthopaed Res 19:927
Akkus O, Adar F, Schaffler MB (2004) Bone 34:443
Currey JD (1984) Biol Sci 304:509
Wasserman N, Yerramshetty J, Akkus O (2005) Eur J Morphol 42:43
Akkus O, Yeni YN, Wasserman N (2004) Crit Rev Biomed Eng 32:379
Vashishth D (2005) Crit Rev Euk Gene Expr 15:343–357
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Taylor, D. Fracture and repair of bone: a multiscale problem. J Mater Sci 42, 8911–8918 (2007). https://doi.org/10.1007/s10853-007-1698-3
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DOI: https://doi.org/10.1007/s10853-007-1698-3