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Cooperative systems constructed using crystalline metal complexes of short flexible peptides

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Abstract

Biological systems display a range of sophisticated functions that cannot be performed by artificial systems, through intricate cooperative structural changes involving multiple functional units. The designability and structural flexibility of peptides are demonstrated by biological systems that display cooperative structural changes; these properties also make them well-suited for the formation of artificial systems that display such changes. The problem with the use of peptide frameworks is that long peptide residues, which are not suitable for gram-scale use, are required for the formation of stable ordered structures. However, if ordered structures containing peptides could be constructed by coordinating them to metal ions, peptides could be widely used to develop sophisticated functional materials. Crystal packing can be used for the design of functional materials made from simple molecules because it provides a way to place the components relative to each other. Although crystalline systems have been reported in which the small size of the cavities has been attributed to the flexibility of the peptide, recently, large systems with giant cavities have been developed with flexible peptides. In this review, we summarize the formation of cooperative multicomponent systems in the crystalline state using metal complexes of simple peptides, along with recent advances in the construction of giant artificial systems using short peptides.

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Acknowledgements

The author thanks the organizing committee of Host-Guest and Supramolecular Chemistry Society, Japan for giving him the SHGCS Japan Award of Excellence 2021 and the opportunity to write this review. This work was financially supported by a JSPS KAKENHI Grant-in-Aid for Scientific Research (C) (20K05539), a JSPS KAKENHI Grant-in-Aid for Young Scientists (B) (25810037), and JST PRESTO (JPMJPR151A). The author would also like to thank all the collaborators who contributed to the work described in this review. This is a paper selected for the “SHGCS Japan Award of Excellence 2021”.

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  1. Department of Chemistry and Biochemistry, Graduate School of Humanities and Sciences, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, 112-8610, Tokyo, Japan

    Ryosuke Miyake

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Miyake, R. Cooperative systems constructed using crystalline metal complexes of short flexible peptides. J Incl Phenom Macrocycl Chem 102, 711–722 (2022). https://doi.org/10.1007/s10847-022-01145-2

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