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Organic transistor-based chemical sensors with self-assembled monolayers

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Abstract

Numerous artificial receptors with noncovalent bonds have been developed to date, whereas chemical sensing devices combined with these receptors have not been fully established. An organic thin-film transistor (OTFT) can potentially operate as a supramolecular sensor chip by appropriately combining it with molecular recognition parts. In this review, the attempts to fabricate devices for electrical chemical sensing utilizing a self-assembled monolayer on a gate electrode or a surface of a semiconductor layer of the OTFT are described. Self-assembled scaffolds provide multi-recognition sites, leading to selective and sensitive detection. Furthermore, the OTFT functionalized with various receptors provide comprehensive sensor platforms for multiple analytes including cations, anions, electrically neutral molecules, and proteins in aqueous media. The OTFT-based sensor successfully detected analytes with size and chemical structural dependences on self-assembled receptors. Moreover, real-time continuous detection was also accomplished by the OTFT-based sensor integrated with a microfluidic system. Thus, this concept implies a promising future for applying an easy-to-use chemical sensor in practical situations by taking advantage of well-developed supramolecular interactions.

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Fig. 1
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Reproduced with permission from [33]. Copyright 2015, Royal Society of Chemistry

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Reproduced with permission from [33] Copyright 2015, Royal Society of Chemistry

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Reproduced with permission from [44]. Copyright 2015, Royal Society of Chemistry

Fig. 8

Reproduced with permission from [62]. Copyright 2020, IOP Publishing

Fig. 9
Fig. 10

Reproduced with permission from [70]. Copyright 2017, John Wiley & Sons

Fig. 11

Reproduced with permission from Ref. [77]. Copyright 2016, Elsevier

Fig. 12

Reproduced with permission from [81]. Copyright 2020, John Wiley & Sons

Fig. 13

Reproduced with permission from [90]. Copyright 2018, Royal Society of Chemistry

Fig. 14

Reproduced with permission from [90]. Copyright 2018, Royal Society of Chemistry

Fig. 15

Reproduced with permission from Ref. [91]. Copyright 2020, John Wiley & Sons

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Acknowledgements

The author would like to extend his gratitude to the committee members of the Association of Research for Host−Guest and Supramolecular Chemistry for the “SHGSC Japan Award of Excellence 2020.” The author would like to thank JSPS KAKENHI for the financial support with Grant Nos. JP20H05207 and JP20K21204. This work was also financially supported by the Noguchi Institute, JST CREST (Grant No. JPMJCR2011), and AGC Inc., which supplied the Cytop®.

Funding

The funding was supported by Japan Society for the Promotion of Science (Grant Nos. JP20H05207, JP20K21204), Noguchi Institute and Japan Science and Technology Agency (Grant No. JPMJCR2011).

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  1. Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8505, Japan

    Tsuyoshi Minami

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  1. Tsuyoshi Minami
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Correspondence to Tsuyoshi Minami.

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This paper was selected for the “SHGSC Japan Award of Excellence 2020”.

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Minami, T. Organic transistor-based chemical sensors with self-assembled monolayers. J Incl Phenom Macrocycl Chem 101, 1–18 (2021). https://doi.org/10.1007/s10847-021-01050-0

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