Binding, and thermodynamics of β-cyclodextrin inclusion complexes with some coumarin laser dyes and coumarin-based enzyme substrates: a simulation study

  • M. S. A. Abdel-MottalebEmail author
  • E. Hamed
  • M. Saif
  • Hoda S. Hafez
Original Article


This paper addresses modelling the nature of interactions between β-CD and some coumarins including recently reported novel sulphur analogues to form inclusion complexes of appealing medicinal, photochemical and photophysical properties. The binding energy and the total stabilization energy (EONIOM) are used to confirm the most favorable inclusion complex structure. Thermodynamic parameters reveal exothermic inclusion reaction in gas phase. Thermal stability of fluorescent enzyme substrate of coumarin nucleus increases in the order: gas < cyclohexane < water, indicating better stability in water. Furthermore, molecular characteristics such as optimized geometries, MO’s and electrostatic potential energy map surfaces and energies are reported and correlated with some reactivity indices. Our results validated the experimentally available data reported in the literature. Inclusion complexes of β-CD with coumarins should result in improving its laser efficiency in environmentally benign aqueous medium.


Coumarins β-Cyclodextrin DFT ONIOM 



This study was funded by Ain Shams University.


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© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Nano-Photochemistry, Solarchemistry and Computational Chemistry Labs, Department of Chemistry, Faculty of ScienceAin Shams UniversityCairoEgypt
  2. 2.Department of Chemistry, Faculty of EducationAin Shams UniversityRoxyEgypt
  3. 3.Environmental Studies and Research InstituteUniversity of Sadat CitySadat CityEgypt

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