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Complexion of Kadsura coccinea extract with cyclodextrin: characterization, thermal stability, antioxidative properties in vitro and the protective effects on kidney damage

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Abstract

This work investigated the thermal stabilities and antioxidative effects of the inclusion complexion of Kadsura coccinea extract (AE) with cyclodextrin (CD). AE/CD complexes were prepared with β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD), respectively. The inclusion complexation was characterized by UV, FT-IR and Scanning electron microscopy (SEM). The presence of CDs enhanced the thermal stability of AE by thermal gravity analysis (TGA). The antioxidant assays in vitro and the protective effects on kidney damage induced by potassium bromate (KBrO3) showed that the complexation of AE with cyclodextrin could increase its antioxidative effects in an order of AE/2-HP-β-CD complexes > AE/β-CD complexes > free AE.

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Acknowledgements

This work was financially supported by National Science Foundation for Young Scholars of China (No. 30901853).

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    Authors and Affiliations

    1. College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China

      Kaidi Su, Yanmei Li, Xiaolei Huang, Lei Zhao, Qirun Li, Meng Li, Heran Li & Jian Zhang

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    1. Kaidi Su
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    2. Yanmei Li
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    3. Xiaolei Huang
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    4. Lei Zhao
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    5. Qirun Li
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    7. Heran Li
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    8. Jian Zhang
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    Correspondence to Heran Li or Jian Zhang.

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    All of the authors do not have any possible conflicts of interest.

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    Kaidi Su and Yanmei Li contributed equally to this work.

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    Su, K., Li, Y., Huang, X. et al. Complexion of Kadsura coccinea extract with cyclodextrin: characterization, thermal stability, antioxidative properties in vitro and the protective effects on kidney damage. J Incl Phenom Macrocycl Chem 91, 141–148 (2018). https://doi.org/10.1007/s10847-018-0804-2

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    • DOI: https://doi.org/10.1007/s10847-018-0804-2

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