A polyrotaxane gel using boronic acid-appended γ-cyclodextrin as a hybrid cross-linker

  • Wataru Uchida
  • Maiki Yoshikawa
  • Tomohiro Seki
  • Ryotaro Miki
  • Toshinobu Seki
  • Takashi Fujihara
  • Yoshihiro Ishimaru
  • Yuya Egawa
Original Article
  • 243 Downloads

Abstract

A boronic acid-appended γ-cyclodextrin (BA-CyD) was synthesized as a hybrid cross-linker of polyvinyl alcohol (PVA) to form a new type of hydrogel. The CyD moiety of BA-CyD forms an inclusion complex with the PVA chain to produce a mechanically interlocking structure. At the same time, the BA moiety of BA-CyD forms covalent bonds with the 1,3-diol moieties of PVA. On the basis of these two modes of interaction, the hybrid cross-linker connects two PVA chains, thus resulting in the formation of a hydrogel. To investigate the possibility of this hydrogel becoming the basis for an intelligent material for drug delivery, sugar-responsive drug release from the hydrogel was demonstrated.

Keywords

Cyclodextrin Boronic acid Polyrotaxane Gel Intelligent material Sugar response 

Supplementary material

10847_2017_755_MOESM1_ESM.pdf (112 kb)
Supplementary material 1 (PDF 112 KB)

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  1. 1.Faculty of Pharmacy and Pharmaceutical SciencesJosai UniversitySakadoJapan
  2. 2.Research and Development Bureau, Comprehensive Analysis Center for ScienceSaitama UniversitySaitamaJapan
  3. 3.Division of Material Science, Graduate School of Science and EngineeringSaitama UniversitySaitamaJapan

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