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Application of cyclodextrins in cancer treatment

  • Neng Qiu
  • Xuebing Li
  • Junda Liu
Review Article

Abstract

Cancer is one of the major fatal diseases. Chemotherapy is a typical treatment method that uses a combination of drugs to either destroy cancer cells or slow down the growth of cancer cells. However, most of the cytotoxic chemotherapeutic drugs are water insoluble resulting in formulation difficulty. One promising strategy is to use cyclodextrins (CDs) which have been widely employed to enhance the solubility, bioavailability, stability and safety of drug molecules by forming non covalent inclusion complexes. The objective of this review is to explain the use of CDs in the different approaches for cancer treatment. Of specific interest is that CDs are shown to have anticancer activity both in vitro and in vivo. The use of CDs as anticancer agent and the possible mechanism to inhibit cancer cell growth are discussed. CDs/anti-neoplastic-drug complexes with improved solubility, increased stability and enhanced anti-cancer activity are described and possible future applications are discussed. Use and their advantages of CDs in the different drug delivery systems like liposomes, conjugates, nanoparticles and siRNA carriers for cancer treatment are detailed in this review. These CDs modified delivery system for anticancer drugs are shown to provide improved encapsulation, prolonged release, increased therapeutic efficacy and reduced toxicity. Furthermore, there is a prerequisite to exploit the utility of CDs and CDs-based carriers using in vivo tumor models for pharmacokinetics, pharmacodynamics and toxicity studies to validate their safety and efficacy. In future, we believe that CDs and CDs-based delivery system for anticancer drugs have great potential to serve as an alternative for cancer treatment.

Keywords

Cyclodextrin Anti-cancer, Inclusion complex Delivery Solubilization 

Notes

Acknowledgements

The authors are thankful to National Natural Science Foundation of China (NSFC) (21606025), and the foundation for the Youth Scholars of Chengdu University of Technology (10912-KYGG201517) for providing financial assistance relating to this work.

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  1. 1.Department of Chemical & Pharmaceutical Engineering, College of Materials and Chemistry and Chemical EngineeringChengdu University of TechnologyChengduPeople’s Republic of China
  2. 2.Department of Oral and Maxillofacial Surgery, West China School of StomatologySichuan UniversityChengduPeople’s Republic of China

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