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Inclusion complex of Isatoic anhydride with β-cyclodextrin and supramolecular one-pot synthesis of 2, 3-dihydroquinazolin-4(1H)-ones in aqueous media

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Abstract

The inclusion complex of isatoic anhydride with β-cyclodextrin was formed as a result of intermolecular interaction between isatoic anhydride with β-CD. The inclusion complex was confirmed by IR spectroscopy, X-ray diffraction and DSC studies. From application of complex, herein we have described a simple and efficient protocol for synthesis of 2, 3-dihydroquinazoline-4(1H)-one derivatives by one pot condensation of isatoic anhydride, ammonium acetate or amine and aldehyde using β-CD as a supramolecular catalyst in aqueous media.

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Acknowledgments

The authors are thankful to Department of Science and Technology and University Grants Commission, New Delhi, India for financial support of this work. We are also thankful to Dr. K. J. Patil, Emeritus Professor, School of Chemical Sciences for useful suggestions.

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Authors and Affiliations

  1. Department of Organic Chemistry, North Maharashtra University, Jalgaon, 425 001, MS, India

    Dipak R. Patil & Dipak S. Dalal

  2. Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR), Bhavnagar, 364 021, Gujarat, India

    Pravin G. Ingole & Kripal Singh

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  1. Dipak R. Patil
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Correspondence to Dipak S. Dalal.

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Patil, D.R., Ingole, P.G., Singh, K. et al. Inclusion complex of Isatoic anhydride with β-cyclodextrin and supramolecular one-pot synthesis of 2, 3-dihydroquinazolin-4(1H)-ones in aqueous media. J Incl Phenom Macrocycl Chem 76, 327–332 (2013). https://doi.org/10.1007/s10847-012-0203-z

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