Abstract
Interaction between cucurbit[8]uril (Q[8]) with a fungicide, carboxin in aqueous solution, was investigated by 1H-NMR, electronic absorption spectroscopy, and fluorescence spectroscopy. Spectroscopy analysis established a basic interaction model which formed an inclusion complex with a host:guest ratio of 1:1. 1H-NMR showed that Q[8] encapsulated the phenyl ring into its cavity and the rest of the guest molecule stayed outside the host. Comparative in vitro evaluations of the growth inhibitory effects of the inclusion complex solution toward Rhizoctonia solani demonstrated appreciable improvements in the antifungal activity of carboxin through the addition of Q[8]. In comparison with the positive control, improvement was evaluated in terms of area covered by the mycelia of R. solani and their growth inhibition rate. Inclusion complexation of carboxin with Q[8] suggests a potential means for production of an environmentally friendly carboxin-based fungicide to counteract R. solani.
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Acknowledgments
We acknowledge the support of the National Natural Science Foundation of China (Grant No. 20972034), Natural Science fund of the Science and Technology Department of GuiZhou Province (Grant No. J-2009-2288), Natural Science project of the department of education of Guizhou Province (Grant No. 2010013), Introduced Talents Start-up Project of GuiZhou University (Grant No. 2009023) and the Foundation of the Governor of Guizhou Province.
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Liu, H., Wu, X., Huang, Y. et al. Improvement of antifungal activity of carboxin by inclusion complexation with cucurbit[8]uril. J Incl Phenom Macrocycl Chem 71, 583–587 (2011). https://doi.org/10.1007/s10847-011-9982-x
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DOI: https://doi.org/10.1007/s10847-011-9982-x