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Host–guest complexation between 5-aminoisoquinoline and β-cyclodextrin and its effect on spectral and prototropic characteristics

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Abstract

The effects of the addition of β-cyclodextrin (β-CDx) on the absorption and emission properties of the 5-aminoisoquinoline (5AIQ) have been investigated in aqueous media. The formation of host–guest inclusion complex with 1:1 stoichiometry was revealed by absorption, steady state and time-resolved emission spectroscopy. The complex formation has also been confirmed by FT-IR spectra and SEM image analysis of the solid inclusion complex between 5AIQ and β-CDx. No significant change was observed in the ground and excited state pKa values in β-CDx medium. Based on photophysical and prototropic characteristics of 5AIQ in β-CDx, the structure of the 1:1 inclusion complex is proposed.

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Acknowledgement

We are grateful to the National Centre for Ultrafast Processes, University of Madras, Chennai, for the assistance in the measurements of the fluorescence lifetimes.

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Authors and Affiliations

  1. Department of Chemistry, Annamalai University, Annamalainagar, Chidambaram, 608 002, India

    Meenakshisundaram Swaminathan

  2. Chemistry Section, FEAT, Annamalai University, Annamalainagar, Chidambaram, 608 002, India

    Sundarrajulu Kothai Nayaki

  3. Department of Chemistry, SKP Institute of Technology, Tiruvannamalai, 606 611, India

    Rajaram Rajamohan

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  1. Rajaram Rajamohan
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  2. Sundarrajulu Kothai Nayaki
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  3. Meenakshisundaram Swaminathan
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Correspondence to Meenakshisundaram Swaminathan.

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Rajamohan, R., Kothai Nayaki, S. & Swaminathan, M. Host–guest complexation between 5-aminoisoquinoline and β-cyclodextrin and its effect on spectral and prototropic characteristics. J Incl Phenom Macrocycl Chem 73, 99–108 (2012). https://doi.org/10.1007/s10847-011-0025-4

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