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The effects of water-soluble polymers on hydroxypropyl-β-cyclodextrin solubilization of oleanolic acid and ursolic acid

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Abstract

The objective of this study was to investigate the influence of water-soluble polymers on the complex formation of hydroxypropyl-β-cyclodextrin (HP-β-CD) with oleanolic acid (OA) and ursolic acid (UA), two insoluble isomeric triterpenic acids. The interactions of OA and UA with HP-β-CD in water-soluble polymer solutions were studied by ultraviolet (UV) spectrophotometry. Phase-solubility studies were carried out to evaluate the solubilizing power of HP-β-CD, in association with water-soluble polymers, towards OA and UA. UV spectra indicated that the absorption intensity decreased upon the addition of HP-β-CD both in the absence and presence of water-soluble polymers. Stability constants were also calculated from the UV spectra. When water-soluble polymers were added, both the solubilization effect and the complexation efficiency (CE) of HP-β-CD with the isomers decreased. The experimental results suggested that the addition of water-soluble polymers inhibit the solubilization effect of HP-β-CD with OA and UA.

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Acknowledgements

This work was financially supported by Natural Science Fund Project of Colleges in Jiangsu Province (Project No. 07KJD350152), Jiangsu provincial Bureau of Traditional Chinese Medicine (Project No. HL07068), Jiangsu provincial Institute of Traditional Chinese Medicine (Project No. KF2005004) and Nanjing Medical University (Project No. 2005NYDZD12). The authors are grateful to the Department of Biotechnology, College of Basic Medical Science, Nanjing Medical University for their help during the experimental work.

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  1. School of Pharmacy, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, People’s Republic of China

    Peng Quan, Dongfei Liu, Rui Li, Qing Zhang, Yong Qian & Qunwei Xu

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  1. Peng Quan
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  2. Dongfei Liu
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  3. Rui Li
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  4. Qing Zhang
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  5. Yong Qian
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  6. Qunwei Xu
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Correspondence to Qunwei Xu.

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P. Quan and D. Liu contributed equally to this work.

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Quan, P., Liu, D., Li, R. et al. The effects of water-soluble polymers on hydroxypropyl-β-cyclodextrin solubilization of oleanolic acid and ursolic acid. J Incl Phenom Macrocycl Chem 63, 181–188 (2009). https://doi.org/10.1007/s10847-008-9505-6

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  • DOI: https://doi.org/10.1007/s10847-008-9505-6

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