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Nanoscale substrate recognition by porphyrin dendrimers with patched structures

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Abstract

Dendrimer technology has enabled us to build macromolecules with nanosized defined structures. By introducing unsymmetrical patched structures in dendrimers, sophisticated artificial receptors exhibiting nanoscale substrate recognition can be obtained. In this review article, our recent studies on molecular recognition by porphyrin dendrimers with patched structures are summarized. Three topics are presented: (1) oligopeptide-patched dendrimers as a nanoscale receptor of cytochrome c protein; (2) pocket dendrimers as a nanoscale receptor for bimolecular guest accommodation; and (3) energy transfer in unsymmetrical dendrimers. These dendrimers nicely mimic proteins and enzymes, and also act as photofunctional artificial receptors, in which porphyrin’s strong photoabsorption and intense fluorescence signals can respond sensitively to the substrate binding.

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Acknowledgments

The author thanks the Organizing Committee of Host-Guest and Supramolecular Chemistry Society, Japan for giving him the HGCS Japan Award of Excellence 2006 and the opportunity to write this review article. He acknowledges all collaborators for their efforts. He especially thanks Prof. Hiroshi Tsukube for his suggestions and discussion about all the research on dendrimers, Dr. Dharam Paul for his contribution to dendrimer synthesis, and Dr. Ichiro Akai for being a co-worker and for discussion about the energy transfer processes in dendrimers. Figures 4 and 7 were reproduced with permission from the Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

This is a paper selected for “HGCS Japan Award of Excellence 2006”.

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  1. Department of Chemistry, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka, 558-8585, Japan

    Satoshi Shinoda

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Shinoda, S. Nanoscale substrate recognition by porphyrin dendrimers with patched structures. J Incl Phenom Macrocycl Chem 59, 1–9 (2007). https://doi.org/10.1007/s10847-007-9315-2

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