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Preparation and investigation of mixtures containing lidocaine base and β-cyclodextrin

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Abstract

The effects of β-cyclodextrin (β-CD) on the solubility properties of lidocaine base were studied. Products were prepared by physical mixing, kneading, spray-drying and precipitation methods in drug : β-CD ratios of 3:1, 2:1, 1:1, 1:2 and 1:3. Some auxiliary materials (hydroxy acids, etc.) were also used. The solubility and the rate of dissolution both in distilled water and in artificial gastric juice, the in vitro diffusion, the thermoanalytical properties (TG, DTG, DSC and DTA) and the surface tension were determined, and the measured results were compared with the corresponding data for lidocaine hydrochloride.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, University of Szeged, Eötvös utca 6, Szeged, 6720, Hungary

    Anita Tatai, Zoltán Aigner, István Erős & Mihály Kata

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  1. Anita Tatai
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  2. Zoltán Aigner
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  3. István Erős
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  4. Mihály Kata
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Correspondence to Mihály Kata.

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Tatai, A., Aigner, Z., Erős, I. et al. Preparation and investigation of mixtures containing lidocaine base and β-cyclodextrin. J Incl Phenom Macrocycl Chem 59, 105–113 (2007). https://doi.org/10.1007/s10847-007-9302-7

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  • DOI: https://doi.org/10.1007/s10847-007-9302-7

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