Abstract
The interaction of piroxicam (PX) with sulfobutylether-β-cyclodextrin (SBE-β-CD) was studied by fluorescence spectroscopy and compared with that of hydroxypropyl-β-cyclodextrin (HP-β-CD). The stability constants (K) values for the PX-CDs complexes were obtained by steady-state fluorescence measurements. Inclusion conditions including concentrations of the two cyclodextrins and pH values were investigated for the complex formation in detail. The results suggested that the interaction of PX with charged CD (SBE-β-CD) is much stronger than that with uncharged CD (HP-β-CD) at any pH studied, in terms of a synergetic effect of hydrophobic and additional electrostatic interactions.
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The work was supported by the National Natural Science Foundation of China (No. 20575037) and Shanxi Province (No. 20031019).
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ZHOU, Y., ZHANG, G., WANG, Z. et al. The Interaction of Piroxicam with Neutral (HP-β-CD) and Anionically Charged (SBE-β-CD) β-cyclodextrin. J Incl Phenom Macrocycl Chem 56, 215–220 (2006). https://doi.org/10.1007/s10847-006-9086-1
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DOI: https://doi.org/10.1007/s10847-006-9086-1