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Glyconanocavities: Cyclodextrins and Beyond

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Abstract

Cyclodextrins (CDs) represent a unique example of complementarity between nanotechnology and biotechnology. Their molecular nanocavity character and the possibility of selective functionalization offer an excellent opportunity for chemical elaboration of unique nanostructures in a three-dimensional network. Several approaches from our laboratories, aimed at endowing CDs with biorecognition properties by incorporation of saccharide ligands, are discussed. Applications range from site-specific drug delivery systems to more fundamental studies on carbohydrate–protein interactions. Results on the de novo synthesis of a new family of glyconanocavities constructed from α,α-trehalose building blocks, namely cyclotrehalans (CTs), and on their complexing properties are also presented.

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Authors and Affiliations

  1. Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, E-41092, Sevilla, Spain

    Jose M. Garcia Fernandez

  2. Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Aptdo. 553, E-41071, Sevilla, Spain

    Carmen Ortiz Mellet

  3. Département de Pharmacochimie Moléculaire, CNRS-Université Joseph Fourier-Grenoble 1, (UMR 5063, FR 2607 ICMG), BP 138, F-38243, Meylan, France

    Jacques Defaye

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  1. Jose M. Garcia Fernandez
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  2. Carmen Ortiz Mellet
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  3. Jacques Defaye
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Correspondence to Jose M. Garcia Fernandez.

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Fernandez, J.M.G., Mellet, C.O. & Defaye, J. Glyconanocavities: Cyclodextrins and Beyond. J Incl Phenom Macrocycl Chem 56, 149–159 (2006). https://doi.org/10.1007/s10847-006-9076-3

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