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Release Characteristics of Iodine Encapsulated in Cyclodextrins

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Abstract

The effect of cyclodextrins (CDs) on water solubility of iodine was investigated. Modified CDs greatly enhanced the solubility of iodine. On the contrary, enhancement by natural CDs was rather moderate whereby the solubility was only doubled at the highest β-CD concentration examined. Desorption experiment of iodine from solution was carried out with addition of various CDs to study the effect of CDs on iodine retention. α-CD was the most efficient in retarding iodine desorption. Later, various concentrations of α-CD were used in the desorption experiment to observe its volatile suppression effect and determine the stability constant of iodine/α-CD complexation. At α-CD concentration of 10.3 mM, no lost of iodine from the solution was detected. A model was developed for desorption of iodine from the solution based on mass transfer theory. The stability constant K given by this model was 3.28×104 M−1 which was in the same order as the value estimated in this study by solubility method and as well those reported by other authors. In release experiments of solid state inclusion complexes, stability of inclusion complex powders decreased in the order of α-CD>β-CD>randomly methylated β-CD (RM-β-CD).

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Acknowledgment

This study was partly supported by a Grant-in-Aid for Scientific Research (c) (No. 17580110) from the Ministry of Education, Science, and Culture of Japan. The authors also acknowledge Nippoh Chemicals Co., Ltd. (Tokyo, Japan) for their kind gift of the MCDI-6 solution.

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Authors and Affiliations

  1. Department of Biotechnology, Tottori University, 4-101 Koyamacho-minami, 680-8552, Tottori, Japan

    Tze-Loon Neoh, Yasuhiro Noda, Hidefumi Yoshii & Takeshi Furuta

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  1. Tze-Loon Neoh
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  2. Yasuhiro Noda
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  3. Hidefumi Yoshii
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  4. Takeshi Furuta
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Correspondence to Hidefumi Yoshii.

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Neoh, TL., Noda, Y., Yoshii, H. et al. Release Characteristics of Iodine Encapsulated in Cyclodextrins. J Incl Phenom Macrocycl Chem 56, 117–123 (2006). https://doi.org/10.1007/s10847-006-9072-7

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  • DOI: https://doi.org/10.1007/s10847-006-9072-7

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