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Electrospray Ionization Mass Spectrometry (ESI-MS) as a Useful Tool for Fast Evaluation of Anion and Cation Complexation Abilities of a Cyclam Derivative

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Abstract

Electrospray ionization mass espectrometry (ESI-MS) has been used for the study of a cyclam derivative noncovalent interactions. At acidic pH, diprotonated macrocycle bound to different anionic species were observed. The selectivity shown by competitive experiments is rationalized with the help of semiempirical theoretical calculations. At basic pH, the base peak corresponded to the macrocycle-alkaline metal complexes, and again competition experiments showed different binding strength. Finally, experiments carried out in the presence of transition metal salts allowed the detection of the complexes present in the mixture and revealed their different kinetic behavior.

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Authors and Affiliations

  1. Departamento de Química Inorgánica y Orgánica , Universidad Jaume I, E-12071, Castellón, Spain

    Ignacio Alfonso

  2. Departamento de Química Orgánica e Inorgánica. Facultad de Química, Universidad de Oviedo, E-33006, Oviedo, Spain

    Covadonga Astorga & Vicente Gotor

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  1. Ignacio Alfonso
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  2. Covadonga Astorga
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  3. Vicente Gotor
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Correspondence to Vicente Gotor.

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Alfonso, I., Astorga, C. & Gotor, V. Electrospray Ionization Mass Spectrometry (ESI-MS) as a Useful Tool for Fast Evaluation of Anion and Cation Complexation Abilities of a Cyclam Derivative. J Incl Phenom Macrocycl Chem 53, 131–137 (2005). https://doi.org/10.1007/s10847-005-1827-z

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  • DOI: https://doi.org/10.1007/s10847-005-1827-z

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