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Cyclodextrin Solubilization of the Antibacterial Agents Triclosan and Triclocarban: Effect of Ionization and Polymers

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Abstract

The natural β-cyclodextrin (βCD) and its complexes have limited solubility in aqueous solutions. This low aqueous solubility, as well as low aqueous solubility of the guest molecule (i.e. triclosan or triclocarban (TCC)), can result in low complexation efficiency (CE). The purpose of this study was to enhance the apparent intrinsic solubility (S 0) of the guest molecule and its βCD complexes through ionization and addition of auxiliary compounds such as polymers, amino acids and metal ions. Both triclosan (pK a 7.9) and TCC (pK a 12.7) are weak acids. Addition of ethanol to the complexation medium enhanced S 0 of both triclosan and TCC but at the same time ethanol lowered the stability constant (K c ) of their βCD complexes resulting in overall lowering of CE. Addition of small amount of water-soluble polymers enhanced the βCD solubilization of both guests, and addition lysine enhanced the solubilization of TCC. Ionization of triclosan resulted in significant enhancement of CE and enhanced triclosan release from tablets containing triclosan/βCD complex. The effect of ionization was not as pronounced in the case of TCC.

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Authors and Affiliations

  1. Faculty of Pharmacy, University of Iceland, Hofsvallagata 53, IS-107, Reykjavik, Iceland

    Thorsteinn Loftsson, Ína B. Össurardóttir & Már Másson

  2. deCode genetics Inc., 2501 Davey Road, Woodridge, IL, 60517, USA

    Thorsteinn Thorsteinsson & Matt Duan

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  1. Thorsteinn Loftsson
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  2. Ína B. Össurardóttir
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  3. Thorsteinn Thorsteinsson
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  4. Matt Duan
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  5. Már Másson
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Correspondence to Thorsteinn Loftsson.

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Loftsson, T., Össurardóttir, Í.B., Thorsteinsson, T. et al. Cyclodextrin Solubilization of the Antibacterial Agents Triclosan and Triclocarban: Effect of Ionization and Polymers. J Incl Phenom Macrocycl Chem 52, 109–117 (2005). https://doi.org/10.1007/s10847-004-6048-3

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  • DOI: https://doi.org/10.1007/s10847-004-6048-3

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