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Structure-Chemical Analysis of Multiple Complexations by Cyclodextrins

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Abstract

The interactions between cyclodextrin and substrates having two binding sites in aqueous solution are reviewed. For such substrates, multiple equilibria, NMR chemical shift variations with full binding, solution structures of complexes, and the effect of cavity size are analyzed quantitatively. After general treatments of multiple equilibria and chemical shifts are given, they are applied to three bivalent substrates of diheptanoyllecithin, dialkyldimethylammonium bromide, and oxyphenium bromide for demonstrating their usefulness. The solution structures of complexes play a crucial role in these basic researches as well as the applications of cyclodextrins, such as bitter taste reduction and stabilization of labile substrates.

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References

  1. ML Bender M Komiyama (1978) Cyclodextrin Chemistry, Chap 2 and 3 Springer-Verlag Berlin

    Google Scholar 

  2. J Szejtli T Osa (1996) Cyclodextrins Pergamon London

    Google Scholar 

  3. H-J Schneider F Hacket V Rüdiger H Ikeda (1998) Chem Rev 98 1755

    Google Scholar 

  4. W Saenger J Jacob K Gesseler T Steiner D Hoffmann H Sanbe K Koizumi S Smith T Takaha (1998) Chem Rev 98 1787

    Google Scholar 

  5. K Harata (1998) Chem Rev 98 1803

    Google Scholar 

  6. KB Lipkowitz (1998) Chem Rev 98 1829

    Google Scholar 

  7. MV Rekharsky Y Inoue (1998) Chem Rev 98 1875

    Google Scholar 

  8. KA Connors (1997) Chem Rev 97 1325

    Google Scholar 

  9. A Harada (2001) Acc Chem Res 34 456

    Google Scholar 

  10. N Funasaki (2002) Karhkov Univ Bull 549 1

    Google Scholar 

  11. KA. Connors (1987) Binding Constants Chap 2 John Wiley and Sons New York

    Google Scholar 

  12. C Tanford (1961) Physical Chemistry of Macromolecules, Chap 8 John Wiley and Sons New York

    Google Scholar 

  13. N Funasaki H Yodo S Hada S Neya (1992) Bull Chem Soc Jpn 65 1323

    Google Scholar 

  14. S Ishikawa S Neya N Funasaki (1998) J Phys Chem B 102 2502

    Google Scholar 

  15. N Funasaki S Ishikawa S Neya (2002) Langmuir 18 1786

    Google Scholar 

  16. N Funasaki S Neya (2000) Langmuir 16 5343

    Google Scholar 

  17. Y Matsui S Tokunaga (1996) Bull Chem Soc Jpn 69 2477

    Google Scholar 

  18. N Funasaki M Nomura H Yamaguchi S Ishikawa S Neya (2000) Bull Chem Soc Jpn 73 2727

    Google Scholar 

  19. N Funasaki M Nomura S Ishikawa S Neya (2001) J Phys Chem B 105 7361

    Google Scholar 

  20. N Funasaki HS Ishikawa S Neya (2002) Bull Chem Soc Jpn 75 719

    Google Scholar 

  21. N Funasaki H Yamaguchi S Ishikawa S Neya (2001) J Phys Chem B 105 760

    Google Scholar 

  22. N Funasaki H Yamaguchi S Ishikawa S Neya (2003) Bull Chem Soc Jpn 76 903

    Google Scholar 

  23. N Funasaki S Ishikawa S Neya (2003) J Phys Chem B 107 10094

    Google Scholar 

  24. N Funasaki M Ohigashi S Hada S Neya (2000) Langmuir 16 383

    Google Scholar 

  25. N Funasaki K Kawaguchi S Hada S Neya (1999) J Pharm Sci 88 759

    Google Scholar 

  26. N Funasaki K Kawaguchi S Ishikawa S Hada S Neya T Katsu (1999) Anal Chem 71 1733

    Google Scholar 

  27. N Funasaki S Ishikawa S Neya (2001) J Pharm Sci 90 740

    Google Scholar 

  28. M-J Lehn (1995) Supramolecular Chemistry VCH Verlag Berlin

    Google Scholar 

  29. H-J Schneider A Yatsimirsky (2000) Principles and Methods in Supramolecular Chemistry Wiley New York

    Google Scholar 

Download references

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Authors and Affiliations

  1. Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8414, Japan

    Noriaki Funasaki

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  1. Noriaki Funasaki
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Correspondence to Noriaki Funasaki.

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Funasaki, N. Structure-Chemical Analysis of Multiple Complexations by Cyclodextrins. J Incl Phenom Macrocycl Chem 50, 43–50 (2004). https://doi.org/10.1007/s10847-003-8837-5

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  • DOI: https://doi.org/10.1007/s10847-003-8837-5

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