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The ratio of main pulmonary artery to ascending aorta diameter is associated with the right ventricular outflow tract ventriculararrhythmias

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Journal of Interventional Cardiac Electrophysiology Aims and scope Submit manuscript

Abstract

Background

Although outflow tract (OT) ventricular arrhythmias (VAs) are generally regarded as benign, the relationship between circulation pressure and VAs has received considerable attention in recent years. Previous studies have shown that the ratio of main pulmonary artery (MPA) to ascending aorta (AA) diameter is associated with pulmonary pressure. Here, we investigated whether an elevated MPA/AA ratio is associated with right ventricular OT (RVOT) VAs.

Methods

A total of 67 patients with OT VAs (47 patients with RVOT and 20 patients with LVOT) who underwent cardiac multidetector computed tomography and radiofrequency ablation were enrolled in this study. MPA and AA diameters were measured at the level of the bifurcation of the pulmonary artery. According to the MPA/AA ratio, patients were further divided into two groups: the MPA/AA ratio abnormal group (n = 19), which is defined as MPA/AA ratio ≥ 0.9, and the MPA/AA ratio normal group (n = 48) consisting of patients with an MPA/AA ratio < 0.9.

Results

Patients with RVOT VAs exhibited an elevated MPA/AA ratio (0.84 ± 0.11 vs. 0.75 ± 0.11, p = 0.006). Furthermore, this MPA/AA ratio was shown to be an independent predictor for RVOT VAs (p = 0.013, 95% confidence interval: 1.016–1.145), with an abnormal MPA/AA ratio increasing the odds of RVOT VAs 5.1-fold in patients with OT VAs.

Conclusion

Patients with RVOT VAs exhibited significantly higher MPA/AA ratios compared with those LVOT VAs. The MPA/AA ratio was showed to be an independent predictor RVOT VAs.

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Author notes

  1. Ruikun Jia and Ying Xu contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China

    Ruikun Jia, Ying Xu, Chao Yang, Song Zou, Shenzhen Gong, Ciren Yangzong, Ran Guo & Kaijun Cui

  2. Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610000, People’s Republic of China

    Yichun Luo

  3. Department of Cardiovascular Medicine, The First People’s Hospital of Jintang County, Chengdu, 610041, People’s Republic of China

    Guobin Liu

Authors
  1. Ruikun Jia
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  2. Ying Xu
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  3. Yichun Luo
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  4. Chao Yang
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  5. Song Zou
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  10. Kaijun Cui
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Corresponding authors

Correspondence to Guobin Liu or Kaijun Cui.

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The study was approved by the West China Hospital Ethics Committee.

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The authors declare that they have no conflict of interest.

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Jia, R., Xu, Y., Luo, Y. et al. The ratio of main pulmonary artery to ascending aorta diameter is associated with the right ventricular outflow tract ventriculararrhythmias. J Interv Card Electrophysiol 62, 57–62 (2021). https://doi.org/10.1007/s10840-020-00872-1

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  • DOI: https://doi.org/10.1007/s10840-020-00872-1

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