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Long-term longevity and clinical outcomes of Linox S/SD implantable cardioverter-defibrillator leads: a single-center experience

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Journal of Interventional Cardiac Electrophysiology Aims and scope Submit manuscript

Abstract

Purpose

Since the introduction of the Biotronik Linox S/SD leads in 2006, there have been multiple reports of premature lead failure. The purpose of this study was to investigate the longevity of the Linox S/SD leads and to identify the possible predictors of lead failure in a single tertiary implant center.

Methods

We retrospectively reviewed patients who underwent implantation of Linox S/SD leads or Sorin Vigila 1CR/2CR leads (the same Linox S/SD leads marketed by Sorin) at our center. The cumulative lead survival was estimated using the Kaplan-Meier curve, and variables associated with lead failure were assessed by Cox proportional hazard model.

Results

A total of 187 patients (154 (82%) male) underwent Linox S/SD or Vigila 1CR/2CR implantation between 2007 and 2013. During follow-up with a median time of 75 months, nine lead failures were identified (4.8%). The mean and median times from lead implantation to lead failure were 70.7 ± 21 months and 64 (45–111) months, respectively. The cumulative survival probability for the Linox S/SD at 5 years was 97.1% and at 12 years was 90.3%. Non-physiological high-rate sensing was the most common type of lead failure in patients. In two-thirds of these patients, this led to inappropriate shock. We did not find any significant relationships between patients’ clinical and procedural characteristics and lead failure.

Conclusions

At our center, the 5-year lead survival of the Linox S/SD has been better than reports from other centers. The majority of lead failures presented as non-physiological high-rate sensing with subsequent inappropriate therapy.

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Authors and Affiliations

  1. Monash Cardiac Rhythm Management Department, MonashHeart, Monash Medical Centre, 246 Clayton Road, Clayton, Melbourne, Victoria, 3168, Australia

    Mohammad Alasti, Colin Machado, Sam Mirzaee, Stewart Healy, Logan Bittinger, David Adam, Emily Kotschet, Jack Krafchek & Jeffrey Alison

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  1. Mohammad Alasti
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  2. Colin Machado
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  3. Sam Mirzaee
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  4. Stewart Healy
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  5. Logan Bittinger
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Correspondence to Mohammad Alasti.

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Alasti, M., Machado, C., Mirzaee, S. et al. Long-term longevity and clinical outcomes of Linox S/SD implantable cardioverter-defibrillator leads: a single-center experience. J Interv Card Electrophysiol 61, 115–121 (2021). https://doi.org/10.1007/s10840-020-00787-x

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  • DOI: https://doi.org/10.1007/s10840-020-00787-x

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