Candidemia in patients with cardiovascular implantable electronic devices

Abstract

Purpose

Current guidelines recommend complete extraction of cardiovascular implantable electronic devices (CIEDs) in the case of persistent or recurrent fungemia without other identifiable sources, though supporting evidence is lacking. We sought to evaluate the prognosis of patients with candidemia and CIEDs.

Methods

Twelve consecutive patients (54 ± 12 years, 8 male) with CIED and concurrent candidemia were reviewed.

Results

At the time of diagnosis with candidemia, seven patients were immunocompromised, six were on long-term antibacterial therapy, two were intravenous drug users, four were on chronic hemodialysis, and six had a central venous catheter. Four patients were confirmed as definite CIED infection as vegetation was visible on lead by echocardiogram. The other 8 patients were considered possible CIED infection with candidemia of unknown focus. All patients with visible vegetation underwent CIED removal without complications, and other patients were initially managed non-operatively. After 1 year of follow-up, 7 patients had died and at extended follow-up, all patients without lead removal died while 3 of 4 patients with lead extraction survived. Of note, 50% of deaths in the patients without lead removal were associated with fungal sepsis.

Conclusions

Candida fungemia is associated with a high mortality. CIED removal should be an early consideration in these patients even if lead vegetations are not seen.

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References

  1. 1.

    Greenspon AJ, Patel JD, Lau E, Ochoa JA, Frisch DR, Ho RT, et al. 16-year trends in the infection burden for pacemakers and implantable cardioverter-defibrillators in the United States 1993 to 2008. J Am Coll Cardiol. 2011;58:1001–6.

    Article  Google Scholar 

  2. 2.

    Bongiorni MG, Tascini C, Tagliaferri E, Di Cori A, Soldati E, Leonildi A, et al. Microbiology of cardiac implantable electronic device infections. Europace. 2012;14:1334–9.

    Article  Google Scholar 

  3. 3.

    Hussein AA, Baghdy Y, Wazni OM, Brunner MP, Kabbach G, Shao M, et al. Microbiology of cardiac implantable electronic device infections. J Am Coll Cardiol EP. 2016;2:498–505.

    Google Scholar 

  4. 4.

    Fukunaga M, Goya M, Nagashima M, Hiroshima K, Yamada T, An Y, et al. Identification of causative organism in cardiac implantable electronic device infections. J Cardiol. 2017;70:411–5.

    Article  Google Scholar 

  5. 5.

    Kullberg BJ, Arendrup MC. Invasive candidiasis. N Engl J Med. 2015;373:1445–56.

    CAS  Article  Google Scholar 

  6. 6.

    Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62:e1–50.

    Article  Google Scholar 

  7. 7.

    Kusumoto FM, Schoenfeld MH, Wilkoff BL, Berul CI, Birgersdotter-Green UM, Carrillo R, et al. 2017 HRS expert consensus statement on cardiovascular implantable electronic device lead management and extraction. Heart Rhythm. 2017;14:e503–51.

    Article  Google Scholar 

  8. 8.

    Uslan DZ, Dowsley TF, Sohail MR, Hayes DL, Friedman PA, Wilson WR, et al. Cardiovascular implantable electronic device infection in patients with Staphylococcus aureus bacteremia. Pacing Clin Electrophysiol. 2010;33:407–13.

    Article  Google Scholar 

  9. 9.

    Le Gall J, Lemeshow S, Saulnier F. A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA. 1993;270:2957–63.

    Article  Google Scholar 

  10. 10.

    Kollef M, Micek S, Hampton N, Doherty JA, Kumar A. Septic shock attributed to Candida infection: importance of empiric therapy and source control. Clin Infect Dis. 2012;54:1739–46.

    CAS  Article  Google Scholar 

  11. 11.

    Bassetti M, Merelli M, Ansaldi F, de Florentiis D, Sartor A, Scarparo C, et al. Clinical and therapeutic aspects of candidemia: a five-year single centre study. PLoS One. 2015;10:e0127534.

    Article  Google Scholar 

  12. 12.

    Tumbarello M, Posteraro B, Trecarichi EM, Fiori B, Rossi M, Porta R, et al. Biofilm production by Candida species and inadequate antifungal therapy as predictors of mortality for patients with candidemia. J Clin Microbiol. 2007;45:1843–50.

    CAS  Article  Google Scholar 

  13. 13.

    Kumamoto CA. Candida biofilms. Curr Opin Microbiol. 2002;5:608–11.

    CAS  Article  Google Scholar 

  14. 14.

    Ramage G, Saville SP, Thomas DP, López-Ribot JL. Candida biofilms: an update. Eukaryot Cell. 2005;4:633–8.

    CAS  Article  Google Scholar 

  15. 15.

    Madhavan M, Sohail MR, Friedman PA, Hayes DL, Steckelberg JM, Wilson WR, et al. Outcomes in patients with cardiovascular implantable electronic devices and bacteremia caused by Gram-positive cocci other than Staphylococcus aureus. Circ Arrhythm Electrophysiol. 2010;3:639–45.

    Article  Google Scholar 

  16. 16.

    Wilson HA, Downes TR, Julian JS, White WL, Haponik EF. Candida endocarditis: a treatable form of pacemaker infection. Chest. 1993;103:283–4.

    Article  Google Scholar 

  17. 17.

    Shmuely H, Kremer I, Sagie A, Pitlik S. Candida tropicalis multifocal endophthalmitis as the only initial manifestation of pacemaker endocarditis. Am J Ophthalmol. 1997;123:559–60.

    CAS  Article  Google Scholar 

  18. 18.

    Joly V, Belmatoug N, Leperre A, Robert J, Jault F, Carbon C, et al. Pacemaker endocarditis due to Candida albicans: case report and review. Clin Infect Dis. 1997;25:1359–62.

    CAS  Article  Google Scholar 

  19. 19.

    Kurup A, Janardhan MN, Seng TY. Candida tropicalis pacemaker endocarditis. J Inf Secur. 2000;41:275–6.

    CAS  Google Scholar 

  20. 20.

    Roger PM, Boissy C, Gari-Toussaint M, Foucher R, Mondain V, Vandenbos F, et al. Medical treatment of a pacemaker endocarditis due to Candida albicans and to Candida glabrata. J Inf Secur. 2000;41:176–8.

    CAS  Google Scholar 

  21. 21.

    Cacoub P, Leprince P, Nataf P, Hausfater P, Dorent R, Wechsler B, et al. Pacemaker infective endocarditis. Am J Cardiol. 1998;82:480–4.

    CAS  Article  Google Scholar 

  22. 22.

    Talarmin JP, Boutoille D, Tattevin P, Abgueguen P, Ansart S, Roblot F, et al. Candida endocarditis: role of new antifungal agents. Mycoses. 2009;52:60–6.

    CAS  Article  Google Scholar 

  23. 23.

    Falcone M, Barzaghi N, Carosi G, Grossi P, Minoli L, Ravasio V, et al. Candida infective endocarditis: report of 15 cases from a prospective multicenter study. Medicine. 2009;88:160–8.

    Article  Google Scholar 

  24. 24.

    Halawa A, Henry PD, Sarubbi FA. Candida endocarditis associated with cardiac rhythm management devices: review with current treatment guidelines. Mycoses. 2011;54(4):e168–74.

    Article  Google Scholar 

  25. 25.

    Brown LA, Baddley JW, Sanchez JE, Bachmann LH. Implantable cardioverter-defibrillator endocarditis secondary to Candida albicans. Am J Med Sci. 2001;322:160–2.

    CAS  Article  Google Scholar 

  26. 26.

    Hindupur S, Muslin AJ. Septic shock induced from an implantable cardioverter-defibrillator lead-associated Candida albicans vegetation. J Interv Card Electrophysiol. 2005;14:55–9.

    Article  Google Scholar 

  27. 27.

    Ho IC, Milan DJ, Mansour MC, Mela T, Guy ML, Ruskin JN, et al. Fungal infection of implantable cardioverter-defibrillators: case series of five patients managed over 22 years. Heart Rhythm. 2006;3:919–23.

    Article  Google Scholar 

  28. 28.

    Tascini C, Bongiorni MG, Tagliaferri E, Di Paolo A, Flammini S, Soldati E, et al. Micafungin for Candida albicans pacemaker-associated endocarditis: a case report and review of the literature. Mycopathologia. 2013;175:129–34.

    Article  Google Scholar 

  29. 29.

    Rivera NT, Bray N, Wang H, Zelnick K, Osman A, Vicuña R. Rare infection of implantable cardioverter-defibrillator lead with Candida albicans: case report and literature review. Ther Adv Cardiovasc Dis. 2014;8:193–201.

    Article  Google Scholar 

  30. 30.

    Glavis-Bloom J, Vasher S, Marmor M, Fine AB, Chan PA, Tashima KT, et al. Candida and cardiovascular implantable electronic devices: a case of lead and native aortic valve endocarditis and literature review. Mycoses. 2015;58:637–41.

    Article  Google Scholar 

  31. 31.

    Glockner A. Recurrent candidaemia and pacemaker wire infection with Candida albicans. Mycoses. 2011;54:S20–3.

    Article  Google Scholar 

  32. 32.

    Bandyopadhyay S, Tiwary PK, Mondal S, Puthran S. Pacemaker lead Candida endocarditis: is medical treatment possible? Indian Heart J. 2015;67:S100–2.

    Article  Google Scholar 

  33. 33.

    Riaz T, Nienaber JJC, Baddour LM, Walker RC, Park SJ, Sohail MR. Cardiovascular implantable electronic device infections in left ventricular assist device recipients. Pacing Clin Electrophysiol. 2014;37:225–30.

    Article  Google Scholar 

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Funding

This project described was supported by CTSA award No. UL1 TR002243 from the National Center for Advancing Translational Sciences. Its contents are solely the responsibility of the authors and do not necessarily represent official views of the National Center for Advancing Translational Sciences or the National Institutes of Health.

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Correspondence to Jay A. Montgomery.

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Nakamura, T., Narui, R., Holmes, B. et al. Candidemia in patients with cardiovascular implantable electronic devices. J Interv Card Electrophysiol 60, 69–75 (2021). https://doi.org/10.1007/s10840-020-00706-0

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Keywords

  • Fungemia
  • Cardiovascular implantable electronic devices
  • Lead extraction
  • Candida