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Epidemiology and definition of inappropriate sinus tachycardia

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Inappropriate sinus tachycardia (IST) is a clinical syndrome lacking formal diagnostic criteria. It is generally defined as an elevated resting heart rate (HR; >90–100 bpm) with an exaggerated response to physical or emotional stress and a clearly sinus mechanism. Clinical manifestations are broad from a complete lack of symptoms to incapacitating incessant tachycardia. Now understood to be relatively prevalent, it is observed to have a generally benign prognosis, though symptoms may persist for years. Whether IST is a single discrete entity or a heterogeneous condition with overlap to other syndromes such as postural orthostatic tachycardia syndrome remains a matter of debate.

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Correspondence to Cara N. Pellegrini.

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Pellegrini, C.N., Scheinman, M.M. Epidemiology and definition of inappropriate sinus tachycardia. J Interv Card Electrophysiol 46, 29–32 (2016).

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