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Atrial fibrillation surgery in nonrheumatic mitral valve disease

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Abstract

Atrial fibrillation (AF) is present in 30–50% of patients presenting for mitral valve surgery. If left untreated, AF in these patients is associated with increased morbidity and, possibly, increased mortality. Therefore, concomitant management of the arrhythmia is indicated in most mitral valve patients with preexisting AF. The cut-and-sew Cox-Maze III procedure is extremely effective, eliminating AF in 80–95%; however, it has been supplanted by newer operations that rely upon alternate energy sources to create lines of conduction block. Early and midterm results are good with a variety of technologies. Choice of lesion set remains a matter of debate, but success of ablation appears to be enhanced by a biatrial lesion set and exceeds 90% in some series. Targeted areas for improvement in combined mitral valve surgery and AF ablation include acceptance of uniform standards for reporting results, development of improved technology for ablation and intraoperative assessment, and creation of instrumentation that facilitates minimally invasive approaches.

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References

  1. Nattel, S., & Opie, L. H. (2006). Controversies in atrial fibrillation. Lancet, 36, 262–272.

    Article  Google Scholar 

  2. Gillinov, A. M. (2005). Ablation of atrial fibrillation in mitral valve surgery. Current Opinion in Cardiology, 20, 107–114.

    Article  PubMed  Google Scholar 

  3. Gillinov, A. M., Sirak, J., & Blackstone, E. H., et al. (2005). The Cox maze procedure in mitral valve disease: predictors of recurrent atrial fibrillation. Journal of Thoracic and Cardiovascular Surgery, 130, 1653–1660.

    Article  PubMed  Google Scholar 

  4. Cox, J. L. (2001). Intraoperative options for treating atrial fibrillation associated with mitral valve disease. Journal of Thoracic and Cardiovascular Surgery, 122, 212–215.

    Article  PubMed  CAS  Google Scholar 

  5. Ninet, J., Roques, X., & Seitelberger, R., et al. (2005). Surgical ablation of atrial fibrillation with off-pump, epicardial, high-intensity focused ultrasound: results of a multicenter trial. Journal of Thoracic and Cardiovascular Surgery, 130, 830–839.

    Article  Google Scholar 

  6. Prasad, S. M., Maniar, H. S., & Camillo, C. J., et al. (2003). The Cox maze III procedure for atrial fibrillation: long-term efficacy in patients undergoing lone versus concomitant procedures. Journal of Thoracic and Cardiovascular Surgery, 126, 1822–1828.

    Article  PubMed  Google Scholar 

  7. Ad, N. & Cox, J. L. (2002). Combined mitral valve surgery and the Maze III procedure. Seminars in Thoracic and Cardiovascular Surgery, 14, 206–209.

    PubMed  Google Scholar 

  8. Grigioni, F., Avierinos, J. F., & Ling, L. H., et al. (2002). Atrial fibrillation complicating the course of degenerative mitral regurgitation: determinants and long-term outcome. Journal of the American College of Cardiology, 40, 84–92.

    Article  PubMed  Google Scholar 

  9. Obadia, J.F., el Farra, M., & Bastien, O.H., et al. (1997). Outcome of atrial fibrillation after mitral valve repair. Journal of Thoracic and Cardiovascular, Surgery, 114, 179–185.

    Article  PubMed  CAS  Google Scholar 

  10. Chua, Y. L., Schaff, H. V., & Orszulak, T. A., et al. (1994). Outcome of mitral valve repair in patients with preoperative atrial fibrillation. Should the maze procedure be combined with mitral valvuloplasty? Journal of Thoracic and Cardiovascular Surgery, 107, 408–415.

    CAS  Google Scholar 

  11. Lim, E., Barlow, C. W., & Hosseinpour, A. R., et al. (2001). Influence of atrial fibrillation on outcome following mitral valve repair. Circulation, 104, I59–I63

    Article  PubMed  CAS  Google Scholar 

  12. Jessurun, E.R., van Hemel, N.M., & Kelder, J.C., et al. (2000). Mitral valve surgery and atrial fibrillation: is atrial fibrillation surgery also needed? European Journal of Cardio-Thoracic Surgery, 17, 530–537.

    Article  PubMed  CAS  Google Scholar 

  13. Bando, K., Kasegawa, H., & Okada, Y., et al. (2005). The impact of pre- and postoperative atrial fibrillation on outcome after mitral valvuloplasty for nonischemic mitral regurgitation. Journal of Thoracic and Cardiovascular Surgery, 129, 1032–1040.

    Article  PubMed  Google Scholar 

  14. Bando, K., Kobayashi, J., & Kosakai, Y., et al. (2002). Impact of Cox maze procedure on outcome in patients with atrial fibrillation and mitral valve disease. Journal of Thoracic and Cardiovascular Surgery, 124, 575–583.

    Article  PubMed  Google Scholar 

  15. Handa, N., Schaff, H. V., & Morris, J. J., et al. (1999). Outcome of valve repair and the Cox maze procedure for mitral regurgitation and associated atrial fibrillation. Journal of Thoracic and Cardiovascular Surgery, 118, 628–635.

    Article  PubMed  CAS  Google Scholar 

  16. Bonow, R. O., et al. (2006). ACC/AHA 2006 Practice guidelines for the management of patients with valvular heart disease: executive summary. Journal of the American College of Cardiology, 48(3), e1–e148.

    Article  PubMed  Google Scholar 

  17. Doukas, G., Samani, N.J., & Alexiou, C., et al. (2005). Left atrial radiofrequency ablation during mitral valve surgery for continuous atrial fibrillation. JAMA, 294(18), 2323–2329.

    Article  PubMed  CAS  Google Scholar 

  18. Fuster, V., Ryden, L. E., & Asinger, R. W., et al. (2001). ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to develop guidelines for the management of patients with atrial fibrillation) developed in collaboration with the North American Society of Pacing and Electrophysiology. European Heart Journal, 22, 1852–1923.

    Article  PubMed  CAS  Google Scholar 

  19. Cox, J. L. (2003). Atrial fibrillation I: a new classification system. Journal of Thoracic and Cardiovascular Surgery, 126:1686–1692.

    Article  PubMed  Google Scholar 

  20. Wu, T. J., Kerwin, W. F., & Hwang, C., et al. (2004). Atrial fibrillation: focal activity, re-entry, or both? Heart Rhythm, 1, 117–120.

    Article  PubMed  Google Scholar 

  21. Haissaguerre, M., Jais, P., & Shah, D. C., et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. New England Journal of Medicine, 339, 659–666.

  22. Todd, D.M., Skanes, A.C., & Guiraudon, G., et al. (2003). Role of the posterior left atrium and pulmonary veins in human lone atrial fibrillation: electrophysiological and pathological data from patients undergoing atrial fibrillation surgery. Circulation, 108, 3108–3114.

    Article  PubMed  Google Scholar 

  23. Nitta, T., Ishii, Y., & Miyagi, Y., et al. (2004). Concurrent multiple left atrial focal activations with fibrillatory conduction and right atrial focal or reentrant activation as the mechanism in atrial fibrillation. Journal of Thoracic and Cardiovascular Surgery, 27, 770–778.

    Article  Google Scholar 

  24. Yamauchi, S., Ogasawara, H., & Saji, Y., et al. (2002). Efficacy of intraoperative mapping to optimize the surgical ablation of atrial fibrillation in cardiac surgery. Annals of Thoracic Surgery, 74, 450–457.

    Article  PubMed  Google Scholar 

  25. Harada, A., Konishi, T., & Fukata, M. et al. (2000). Intraoperative map guided operation for atrial fibrillation due to mitral valve disease. Annals of Thoracic Surgery 69:446–450; discussion 450–1.

    Article  PubMed  CAS  Google Scholar 

  26. Harada, A., Sasaki, K., & Fukushima, T., et al. (1996). Atrial activation during chronic atrial fibrillation in patients with isolated mitral valve disease. Annals of Thoracic Surgery, 61, 104–111; discussion 111–2.

    Article  PubMed  CAS  Google Scholar 

  27. Sueda, T., Imai, K., & Ishii, O., et al. (2001). Efficacy of pulmonary vein isolation for the elimination of chronic atrial fibrillation in cardiac valvular surgery. Annals of Thoracic Surgery, 71, 1189–1193.

    Article  PubMed  CAS  Google Scholar 

  28. Schuessler, R. B. (2004). Do we need a map to get through the maze? Journal of Thoracic and Cardiovascular Surgery, 127, 627–628.

    Article  PubMed  Google Scholar 

  29. Pappone, C., Santinelli, V., & Manguso, F., et al. (2004). Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation. Circulation, 109, 327–334.

    Article  PubMed  Google Scholar 

  30. Oral, H., Scharf, C., & Chugh, A., et al. (2003). Catheter ablation for paroxysmal atrial fibrillation: segmental pulmonary vein ostial ablation versus left atrial ablation. Circulation, 108, 2355–2360.

    Article  PubMed  Google Scholar 

  31. Kondo, N., Takahashi, K., & Minakawa, M., et al. (2003). Left atrial maze procedure: a useful addition to other corrective operations. Annals of Thoracic Surgery, 75, 1490–1494.

    Article  PubMed  Google Scholar 

  32. Gaita, F., Gallotti, R., & Calo, L., et al. (2000). Limited posterior left atrial cryoablation in patients with chronic atrial fibrillation undergoing valvular heart sugery. Journal of the American College of Cardiology, 36, 159–166.

    Article  PubMed  CAS  Google Scholar 

  33. Tuinenburg, A.E., Van Gelder, I.C., & Tieleman, R.G., et al. (2000). Mini-maze suffices as adjunct to mitral valve surgery in patients with preoperative atrial fibrillation. Journal of Cardiovascular Electrophysiology, 11, 960–967.

    Article  PubMed  CAS  Google Scholar 

  34. Kalil, R.A., Lima, G.G., & Leiria, T.L., et al. (2002). Simple surgical isolation of pulmonary veins for treating secondary atrial fibrillation in mitral valve disease. Annals of Thoracic Surgery, 73, 1169–1173.

    Article  PubMed  Google Scholar 

  35. Barneet, S. D. & Ad, N. (2006). Surgical ablation as treatment for the elimination of atrial fibrillation: a meta-analysis. Journal of Thoracic and Cardiovascular Surgery, 131, 1029–1035.

    Article  Google Scholar 

  36. Usui, A., Inden, Y., & Mizutani, S., et al. (2002). Repetitive atrial flutter as a complication of the left-sided simple Maze procedure. Annals of Thoracic Surgery, 73, 1457–1459.

    Article  PubMed  Google Scholar 

  37. Cox, J. L., Schuessler, R. B., & Boineau, J. P. (2000). The development of the Maze procedure for the treatment of atrial fibrillation. Seminars in Thoracic and Cardiovascular Surgery, 12, 2–14.

    Article  PubMed  CAS  Google Scholar 

  38. McCarthy, P.M., Gillinov, A.M., & Castle, L., et al. (2000). The Cox-Maze procedure: the Cleveland Clinic experience. Seminars in Thoracic and Cardiovascular Surgery, 12:25–29.

    PubMed  CAS  Google Scholar 

  39. Schaff, H. V., Dearani, J. A., & Daly, R. C., et al. (2000). Cox-Maze procedure for atrial fibrillation: Mayo Clinic experience. Seminars in Thoracic and Cardiovascular Surgery, 12, 30–37.

    PubMed  CAS  Google Scholar 

  40. Scherer, M., Dzemail, O., & Aybeck, T., et al. (2003). Impact of left atrial size reduction on chronic atrial fibrillation in mitral valve surgery. Journal of Heart Valve Disease, 12, 469–474.

    PubMed  Google Scholar 

  41. Gaynor, S. L., Schuessler, R. B., & Bailey, M. S. et al. (2005). Surgical treatment of atrial fibrillation: predictors of late recurrence. Journal of Thoracic and Cardiovascular Surgery, 129, 104–111

    Article  PubMed  Google Scholar 

  42. Isobe, F., & Kawashima, Y. (1998). The outcome and indications of the Cox maze III procedure for chronic atrial fibrillation with mitral valve disease. Journal of Thoracic and Cardiovascular Surgery, 116, 220–227.

    Article  PubMed  CAS  Google Scholar 

  43. Romano, M. A., Bach, D. S., & Paganini, F. D., et al. (2004). Atrial reduction plasty Cox Maze procedure: extended indications for atrial fibrillation surgery. Annals of Thoracic Surgery, 77, 1282–1287.

    Article  PubMed  Google Scholar 

  44. Badwar, V., Rovin, J. D., & Davenport, G., et al. (2006). Left atrial reduction enhances outcomes of modified Maze procedure for permanent atrial fibrillation during concomitant mitral surgery. Annals of Thoracic Surgery, 82, 1758–1764.

    Article  Google Scholar 

  45. Cox, J. L., Ad, N., & Palazzo, T. (1999). Impact of the maze procedure on the stroke rate in patients with atrial fibrillation. Journal of Thoracic and Cardiovascular Surgery, 118, 833–840.

    Article  PubMed  CAS  Google Scholar 

  46. Gillinov, A. M. (2005). Ablation of atrial fibrillation with mitral valve surgery. Current Opinion in Cardiology, 20(2), 107–114.

    Article  PubMed  Google Scholar 

  47. Bakir, I., Casselman, F. P., Brugada, P., et al. (2007). Current strategies in the surgical treatment of atrial fibrillation: review of the literature and Onze Lieve Vrouw Clinic’s strategy. Annals of Thoracic Surgery, 83, 331–340.

    Article  PubMed  Google Scholar 

  48. Ad, N. (2006). How do we spell maze? A dialogue concerning definitions and goals. Journal of Thoracic and Cardiovascular Surgery, 132, 1253–1255.

    Article  PubMed  Google Scholar 

  49. Gillinov, A. M. & McCarthy, P. M. (2004). Advances in the surgical treatment of atrial fibrillation. Cardiology Clinic, 22, 147–157.

    Article  Google Scholar 

  50. Raman, J., Ishikawa, S., & Storer, M. M., et al. (2003). Surgical radiofrequency ablation of both atria for atrial fibrillation: results of a multicenter trial. Journal of Thoracic and Cardiovascular Surgery, 126, 1357–1366.

    Article  PubMed  Google Scholar 

  51. Sie, H.W., Beukema, W.P., & Elvan, A., et al. (2004). Long-term results of irrigated radiofrequency modified maze procedure in 200 patients with concomitant cardiac surgery: six years experience. Annals of Thoracic Surgery, 77, 512–516; discussion 516–7.

    Article  PubMed  Google Scholar 

  52. Gillinov, A.M., Bhavani, S., & Blackstone, E.H., et al. (2006). Surgery for permanent atrial fibrillation: impact of patient factors and lesion set. Annals of Thoracic Surgery, 85, 502–514.

    Article  Google Scholar 

  53. Gaita, F., Riccardi, R., & Caponi, D., et al. (2005). Linear cryoablation of the left atrium versus pulmonary vein cryoisolation in patients with permanent atrial fibrillation and valvular heart disease: correlation of electroanatomic mapping and long-term clinical results. Circulation, 111, 136–142.

    Article  PubMed  Google Scholar 

  54. Luria, D. M., Nemec, J., & Etheridge, S. P., et al. (2001). Intra-atrial conduction block along the mitral valve annulus during accessory pathway ablation: evidence for a left atrial “isthmus.” Journal of Cardiovascular Electrophysiology, 12:744–749.

    Article  PubMed  CAS  Google Scholar 

  55. Cox, J. L., & Ad, N. (2000). The importance of cryoablation of the coronary sinus during the Maze procedure. Seminars in Thoracic and Cardiovascular Surgery, 12, 20–24.

    Article  PubMed  CAS  Google Scholar 

  56. Oral, H., Chugh, A., & Good, E., et al. (2006). A tailored approach to catheter ablation of paroxysmal atrial fibrillation. Circulation, 113, 1824–1831.

    Article  PubMed  Google Scholar 

  57. Pappone, C., Manguso, F., & Vicedomini, G., et al. (2004). Prevention of iatrogenic atrial tachycardia after ablation of atrial fibrillation: a prospective randomized study comparing circumferential pulmonary vein ablation with a modified approach. Circulation, 110, 3036–3042.

    Article  PubMed  Google Scholar 

  58. Calo, L., Lamberti, F., & Loricchio, M., et al. (2006). Left atrial ablation versus biatrial abaltion for persistent and permanent atrial fibrillation: a prospective and randomized study. Journal of the American College of Cardiology, 47, 2504–2512.

    Article  PubMed  Google Scholar 

  59. Viola, N., Williams, M. R., & Ox, M. C., et al. (2002). the technology in use for the surgical ablation of atrial fibrillation. Seminars in Thoracic and Cardiovascular Surgery, 14, 198–205.

    PubMed  Google Scholar 

  60. Melby, S.J., Zierer, A., & Bailey, M.S., et al. (2006). A new era in the surgical treatment of atrial fibrillation: the impact of ablation technology and lesion set on procedural efficacy. Annals of Thoracic Surgery, 244, 583–592.

    Google Scholar 

  61. Chiappini, B., Martin-Suarez, S., & LoForte, A., et al. (2004). Cox/Maze III operation versus radiofrequency ablation for surgical treatment of atrial fibrillation: a comparative study. Annals of Thoracic Surgery, 77, 87–92.

    Article  PubMed  Google Scholar 

  62. Khargi, K., Hutten, B. A., & Lembke, B., et al. (2005). Surgical treatment of atrial fibrillation; a systematic review. European Journal of Cardio-Thoracic Surgery, 27, 258–265.

    Article  PubMed  Google Scholar 

  63. Johnson, W. D., Ganjoo, A. K., & Stone, C. D., et al. (2000). The left atrial appendage: our most lethal human attachment! Surgical implications. European Journal of Cardio-Thoracic Surgery, 17, 718–722.

    Article  PubMed  CAS  Google Scholar 

  64. Garcia-Fernandez, M.A., Perez-David, E., & Quiles, J., et al. (2003). Role of the left atrial appendage obliteration in stroke reduction in patients with mitral valve prolapse: a transesophageal echocardiographic study. Journal of the American College of Cardiology, 42, 1253–1258.

    Article  PubMed  Google Scholar 

  65. Katz, E.S., Tsiamtsiouris, T., & Applebaum, R.M., et al. (2000). Surgical left appendage ligation is frequently incomplete: a transesophageal echocardiographic study. Journal of the American College of Cardiology, 36, 468–471.

    Article  PubMed  CAS  Google Scholar 

  66. Shemin, R. J., Cox, J. L., & Gillinov, A. M., et al. (2007). Guidelines for reporting data and outcomes for the surgical treatment of atrial fibrillation. Annals of Thoracic Surgery, 83, 1225–1230.

    Article  PubMed  Google Scholar 

  67. Gillinov, A. M., Blackstone, E. H., & McCarthy, P. M. (2002). Atrial fibrillation: current surgical options and their assessment. Annals of Thoracic Surgery, 74, 2210–2217.

    Article  PubMed  Google Scholar 

  68. Doll N., Kiaii, B., & Fabricius, A., et al. (2003). Intraoperative left atrial ablation (for atrial fibrillation) using a new argon cryocatheter: early clinical experience. Annals of Thoracic Surgery, 76, 1711–1715.

    Article  PubMed  Google Scholar 

  69. Gillinov, A. M. & Svensson, L. G. (2007). Ablation of atrial fibrillation with minimally invasive mitral surgery. Annals of Thoracic Surgery, 84(3) 1041–1042.

    Google Scholar 

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Acknowledgments

This work is supported by the Atrial Fibrillation Innovation Center, a Third Frontier project funded by the State of Ohio.

Disclosures

Dr. Gillinov is a consultant to Edwards Lifesciences, LLC and to Medtronic, Inc. He is a former consultant to AtriCure, Inc. He has received honoraria for speaking from Medtronic, Inc., St. Jude Medical, Inc., and Boston Scientific. He receives research support from the Atrial Fibrillation Innovation Center, a Third Frontier project funded by the State of Ohio. The Cleveland Clinic has an indirect equity interest in AtriCure, Inc.

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Correspondence to Marc Gillinov.

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Supported by the Atrial Fibrillation Innovation Center, a Third Frontier Project funded by the State of Ohio.

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Gillinov, M. Atrial fibrillation surgery in nonrheumatic mitral valve disease. J Interv Card Electrophysiol 20, 101–107 (2007). https://doi.org/10.1007/s10840-007-9171-4

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