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Pulmonary vein encircling ablation alters the atrial electrophysiologic response to autonomic stimulation

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Journal of Interventional Cardiac Electrophysiology Aims and scope Submit manuscript

Abstract

Objective

Pulmonary vein encircling ablation is often effective in the treatment of atrial fibrillation (AF). The success of the procedure does not depend upon creation of continuous lines of block. Thus mechanisms by which pulmonary vein encircling can cure AF remain unclear. Stimulation of cardiac autonomic ganglia alters atrial refractoriness and potentiates AF. We hypothesized that pulmonary vein encircling alters atrial autonomic function and that these alterations account in part for prevention of AF recurrences following ablation.

Methods

Atrial effective refractory periods (ERP) and AF inducibility were quantified in ten dogs before and during central autonomic nerve stimulation. Pulmonary vein encircling ablation was then performed and electrophysiologic testing repeated. In two dogs subjected to sham procedures measurements were repeated without performance of ablation. Hearts were examined histologically.

Results

Autonomic nerve stimulation led to decreased atrial refractoriness and increased AF inducibility and duration. Each of these effects were attenuated following pulmonary vein encircling (e.g., mean ERP decreased before (−23.7 ± 1.8, p < 0.001) but not after ablation (−2.3 ± 1.9, p = 0.25); AF inducibility increased by 26% before vs. 5% after ablation). No attenuation was seen in the sham operated animals. Histologic analysis following pulmonary vein encircling demonstrated destruction of some but not all autonomic ganglia.

Conclusion

Autonomic stimulation shortens atrial refractory periods and potentiates AF. Pulmonary vein encircling ablation partially destroys atrial autonomic inputs, attenuates the refractory period shortening effect of autonomic stimulation and decreases AF inducibility. Destruction of autonomic ganglia may contribute to the anti-fibrillatory effects of pulmonary vein encircling and warrants further investigation.

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Authors and Affiliations

  1. Department of Medicine, Cardiovascular Research Institute, University of Vermont College of Medicine, and Fletcher Allen Health Care, McClure 1 Cardiology, 111 Colchester Avenue, Burlington, VT, 05401, USA

    Peter Salem Spector, Arshia Mehdi Noori, James Daniel Calame, Steve Paul Bell & Daniel Lawrence Lustgarten

  2. Department of Pathology and the Cardiovascular Research Institute, University of Vermont College of Medicine, and Fletcher Allen Health Care, Burlington, VT, USA

    Nicholas Jackson Hardin

Authors
  1. Peter Salem Spector
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  2. Arshia Mehdi Noori
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  3. Nicholas Jackson Hardin
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  4. James Daniel Calame
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  5. Steve Paul Bell
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  6. Daniel Lawrence Lustgarten
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Corresponding author

Correspondence to Peter Salem Spector.

Additional information

Potential conflict of interest: PSS is a consultant to and receives grant support from Biosense Webster Research Support.

This study was supported by a research alliance with Medtronic Inc., Minneapolis, MN.

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Spector, P.S., Noori, A.M., Hardin, N.J. et al. Pulmonary vein encircling ablation alters the atrial electrophysiologic response to autonomic stimulation. J Interv Card Electrophysiol 17, 119–125 (2006). https://doi.org/10.1007/s10840-006-9056-y

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  • DOI: https://doi.org/10.1007/s10840-006-9056-y

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