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The role of astrocytes in place cell formation: A computational modeling study

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Abstract

Place cells develop spatially-tuned receptive fields during the early stages of novel environment exploration. The generative mechanism underlying these spatially-selective responses remains largely elusive, but has been associated with theta rhythmicity. An important factor implicating the transformation of silent cells to place cells is a spatially-uniform depolarization that is mediated by a persistent sodium current. This neuronal current is modulated by extracellular calcium concentration, which, in turn, is actively controlled by astrocytes. However, there is no established relationship between the neuronal depolarization and astrocytic activity. To consider this link, we designed a bioplausible computational model of a neuronal-astrocytic network, where astrocytes induced the transient emergence of place fields in silent cells, and accelerated the plasticity-induced consolidation of place cells. Interestingly, theta oscillations emerged naturally at the network level, resulting from the astrocytic modulation of subcellular neuronal properties. Our results suggest that astrocytes participate in spatial mapping and exploration, and further highlight the computational roles of these cells in the brain.

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Acknowledgements

This research was supported by the National Center for Medical Rehabilitation Research (NIH/NICHD) K12HD093427 Grant and the Rutgers Office of Research and Innovation. I.P. was partially funded by the Onassis Foundation Scholarship.

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  1. Computational Brain Lab, Department of Computer Science, Rutgers University, New Brunswick, New Jersey, USA

    Ioannis Polykretis & Konstantinos P. Michmizos

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Polykretis, I., Michmizos, K.P. The role of astrocytes in place cell formation: A computational modeling study. J Comput Neurosci 50, 505–518 (2022). https://doi.org/10.1007/s10827-022-00828-6

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