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Parental Problem Drinking is Associated with Children’s Adrenocortical Reactivity to Stress

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Abstract

The hypothalamic–pituitary–adrenal (HPA) axis plays an important role in adaptation to stress, but is vulnerable to chronic stress exposure. Parental problem drinking (PPD) represents such a chronic stressor, but there has been little research on children’s HPA axis activity in the context of PPD. To address this gap, associations between PPD and children’s adrenocortical reactivity were examined, with marital aggression and child emotional security as potential intervening variables. Participants were 69 community families (children aged 6–12 years). Children provided saliva samples before and 20 min after a social stress test, which were assayed for cortisol. Parents reported on their problem drinking (PD) and marital aggression, and children reported on their emotional insecurity about the marital relationship. Mother PD was significantly related to greater adrenocortical reactivity in her offspring. Father PD was significantly related to children’s greater involvement in marital conflict, which was significantly related to greater adrenocortical reactivity. Findings therefore indicate that parental PD is related to greater sensitivity of the HPA axis to social stress, partially because of emotional insecurity.

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References

  • Adinoff, B., Junghanns, K., Kiefer, F., & Krishnan-Sarin, S. (2005). Suppression of the HPA axis stress-response: Implications for relapse. Alcoholism, Clinical and Experimental Research, 29, 1351–1355.

    Article  PubMed Central  PubMed  Google Scholar 

  • Ahnert, L., Gunnar, M. R., Lamb, M. E., & Barthel, M. (2004). Transition to child care: Associations with infant–mother attachment, infant negative emotion, and cortisol elevations. Child Development, 75(3), 639–650.

    Article  PubMed  Google Scholar 

  • Blair, C., Granger, D., Kivlighan, K. T., Mills-Koonce, R., Willoughby, M., Greenberg, M. T., et al. (2008). Maternal and child contributions to cortisol response to emotional arousal in young children from low-income, rural communities. Developmental Psychology, 44, 1095–1109.

    Article  PubMed  Google Scholar 

  • Booth, A., Carver, K., & Granger, D. A. (2000). Biosocial perspectives on the family. Journal of Marriage and Family, 62, 1018–1034.

    Article  Google Scholar 

  • Boyce, W. T., & Ellis, B. J. (2005). Biological sensitivity to context: I. An evolutionary-developmental theory of the origins and functions of stress reactivity. Development and Psychopathology, 17, 271–301.

    Article  PubMed  Google Scholar 

  • Bruce, J., Fisher, P. A., Pears, K. C., & Levine, S. (2009). Morning cortisol levels in preschool-aged foster children: Difference effects of maltreatment type. Developmental Psychobiology, 51(1), 14–23.

    Article  PubMed Central  PubMed  Google Scholar 

  • Chassin, L., Curran, P. J., Hussong, A., & Colder, C. R. (1996). The relation of parent alcoholism to adolescent substance use: A longitudinal follow-up study. Journal of Abnormal Psychology, 105, 70–80.

    Article  PubMed  Google Scholar 

  • Chrousos, G. P., & Gold, P. W. (1992). The concepts of stress and stress system disorders: Overview of physical and behavioral homeostasis. Journal of the American Medical Association, 267, 1244–1252.

    Article  PubMed  Google Scholar 

  • Condren, R. M., O’Neill, A., Ryan, M. C. M., Barrett, P., & Thakore, J. H. (2002). HPA axis response to a psychological stressor in generalized social phobia. Psychoneuroendocrinology, 27, 693–703.

    Article  PubMed  Google Scholar 

  • Congrave, K. M., Hall, W. D., & Saunders, J. B. (1995). The AUDIT questionnaire: Choosing a cut-off score. Addition, 90, 1349–1356.

    Article  Google Scholar 

  • Cummings, E. M., & Davies, P. (1994). Children and marital conflict: The impact of family dispute and resolution. New York: Guilford Press.

    Google Scholar 

  • Cummings, E. M., & Davies, P. (2010). Marital conflict and children: An emotional security perspective. New York: Guilford Press.

    Google Scholar 

  • Cummings, E. M., Goeke-Morey, M. C., Papp, L. M., & Dukewich, T. L. (2002). Children’s responses to mothers’ and fathers’ emotionality and tactics in marital conflict in the home. Journal of Family Psychology, 16, 478–492.

    Article  PubMed  Google Scholar 

  • Davies, P. T., Forman, E. M., Rasi, J. A., & Stevens, K. I. (2002). Assessing children’s emotional security in the interparental relationship: The Security in the Interparental Subsystem Scales. Child Development, 73(2), 544–562.

    Article  PubMed  Google Scholar 

  • Davies, P. T., Sturge-Apple, M. L., & Cicchetti, D. (2011). Interparental aggression and children’s adrenocortical reactivity: Testing an evolutionary model of allostatic load. Development and Psychopathology, 23(03), 801–814.

    Article  PubMed Central  PubMed  Google Scholar 

  • Davies, P. T., Sturge-Apple, M. L., Cicchetti, D., & Cummings, E. M. (2007). The role of child adrenocortical functioning in pathways between interparental conflict and child maladjustment. Developmental Psychology, 43(4), 918–930.

    Article  PubMed Central  PubMed  Google Scholar 

  • Davies, P. T., Sturge-Apple, M. L., Cicchetti, D., & Cummings, E. M. (2008). Adrenocortical underpinnings of children’s psychological reactivity to interparental conflict. Child Development, 79(6), 1693–1706.

    Article  PubMed Central  PubMed  Google Scholar 

  • Davies, P. T., Sturge-Apple, M. L., Cicchetti, D., Manning, L. G., & Zale, E. (2009). Children’s patterns of emotional reactivity to conflict as explanatory mechanisms in links between interpartner aggression and child physiological functioning. Journal of Child Psychology and Psychiatry, 50(11), 1384–1391.

    Article  PubMed Central  PubMed  Google Scholar 

  • Dawes, M. A., Dorn, L. D., Moss, H. B., Yaho, J. K., Kirisci, L., Ammerman, R. T., & Tarter, R. E. (1999). Hormonal and behavioral homeostasis in boys at risk for substance abuse. Drug and Alcohol Dependence, 55, 165–176.

    Article  PubMed  Google Scholar 

  • DeLucia, C., Belz, A., & Chassin, L. (2001). Do adolescent symptomatology and family environment vary over time with fluctuations in paternal alcohol impairment? Developmental Psychology, 37, 207–216.

    Article  PubMed  Google Scholar 

  • Eiden, R., Chavez, F., & Leonard, K. E. (1999). Parent–infant interactions among families with alcoholic fathers. Development and Psychopathology, 11(4), 745–762.

    Article  PubMed Central  PubMed  Google Scholar 

  • Fairchild, G., van Goozen, S. M., Stollery, S. J., Brown, J., Gardiner, J., Herbert, J., & Goodyer, I. M. (2008). Cortisol diurnal rhythm and stress reactivity in male adolescents with early-onset or adolescence-onset conduct disorder. Biological Psychiatry, 64(7), 599–606.

    Article  PubMed Central  PubMed  Google Scholar 

  • Grant, B. F. (2000). Estimates of US children exposed to alcohol abuse and dependence in the family. American Journal of Public Health, 90, 112–115.

    Article  PubMed Central  PubMed  Google Scholar 

  • Gunnar, M. R., & Donzella, B. (2002). Social regulation of the cortisol levels in early human development. Psychoneuroendocrinology, 27, 199–220.

    Article  PubMed  Google Scholar 

  • Gunnar, M. R., & Stone, C. (1984). The effects of positive maternal affect on infant responses to pleasant, ambiguous, and fear-provoking toys. Child Development, 55, 1231–1236.

  • Haller, M., & Chassin, L. (2011). The unique effects of parental alcohol and affective disorders, parenting, and parental negative affect on adolescent maladjustment. Merrill-Palmer Quarterly, 57(3), 4.

    Article  PubMed Central  PubMed  Google Scholar 

  • Hart, J., Gunnar, M., & Cicchetti, D. (1995). Salivary Cortisol in maltreated children- evidence of relations between neuroendocrine activity and social competence. Development and Psychopathology, 7(1), 11–26.

    Article  Google Scholar 

  • Hawes, D. J., Brennan, J., & Dadds, M. R. (2009). Cortisol, callous-unemotional traits, and pathways to antisocial behavior. Current Opinion in Psychiatry, 22, 357–362.

    Article  PubMed  Google Scholar 

  • Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008). The link between childhood trauma and depression: Insights from HPA axis studies in humans. Psychoneuroendocrinology, 33, 693–710.

    Article  PubMed  Google Scholar 

  • Hussong, A. M., Bauer, D. J., Huang, W., Chassin, L., Sher, K. J., & Zucker, R. A. (2008). Characterizing the life stressors of children of alcoholic parents. Journal of Family Psychology, 22(6), 819.

    Article  PubMed Central  PubMed  Google Scholar 

  • Ito, T. A., Miller, N., & Pollock, V. E. (1996). Alcohol and aggression: A meta-analysis on the moderating effects of inhibitory cues, triggering events, and self-focused attention. Psychological Bulletin, 120(1), 60–82.

    Article  PubMed  Google Scholar 

  • Kallen, V. L., Tulen, J. H. M., Utens, E. M. W. J., Treffers, P. D. A., De Jong, F. H., & Ferdinand, R. F. (2008). Associations between HPA axis functioning and level of anxiety in children and adolescents with an anxiety disorder. Depression and Anxiety, 25, 131–141.

    Article  PubMed  Google Scholar 

  • Keller, P. S., Cummings, E. M., Davies, P. T., & Lubke, G. (2007). Children’s behavioral reactions to marital conflict as a function of parents’ conflict behaviors and alcohol problems. European Journal of Developmental Psychology, 4, 157–177.

    Article  Google Scholar 

  • Keller, P. S., Cummings, E. M., Davies, P. T., & Mitchell, P. (2008). Longitudinal relations between parental drinking problems, family functioning, and child adjustment. Development and Psychopathology, 20, 195–212.

    Article  PubMed  Google Scholar 

  • Keller, P. S., El-Sheikh, M., Keiley, M., & Liao, P. J. (2009). Longitudinal relations between marital aggression and alcohol problems. Psychology of Addictive Behaviors, 23, 2–13.

    Article  PubMed  Google Scholar 

  • Keller, P. S., Gilbert, L. R., Koss, K. J., Cummings, E. M., & Davies, P. T. (2011). Parental problem drinking, marital aggression, and child emotional insecurity: A longitudinal investigation. Journal of Studies on Alcohol and Drugs, 72, 711–722.

    Article  PubMed Central  PubMed  Google Scholar 

  • Kilbey, M. M., Downey, K., & Breslau, N. (1998). Predicting the emergence and persistence of alcohol dependence in young adults: The role of expectancy and other risk factors. Experimental and Clinical Psychopharmacology, 6, 149–156.

    Article  PubMed  Google Scholar 

  • Kline, R. B. (2011). Principles and practice of structural equation modeling. New York: Guilford.

    Google Scholar 

  • Koss, K. J., George, M. R., Davies, P. T., Cicchetti, D., Cummings, E. M., & Sturge-Apple, M. L. (2013). Patterns of children’s adrenocortical reactivity to interparental conflict and associations with child adjustment: A growth mixture modeling approach. Developmental Psychology, 49, 317–326.

    Article  PubMed  Google Scholar 

  • Kudielka, B. M., Hellhammer, D. H., & Kirschbaum, C. (2007). Ten years of research with the trier social stress test—revisited. Social Neuroscience: Integrating Biological and Psychological Explanations of Social Behavior, 56–83.

  • Lovallo, W. R., Farag, N. H., Sorocco, K. H., Cohoon, A. J., & Vincent, A. S. (2012). Lifetime adversity leads to blunted stress axis reactivity: Studies from the Oklahoma family health patterns project. Biological Psychiatry, 71, 344–349.

    Article  PubMed Central  PubMed  Google Scholar 

  • Lupien, S. J., King, S., Meaney, M. J., & McEwen, B. S. (2000). Child ‘s stress hormone levels correlatie with mother’s socioeconomic status and depressive state. Biological Psychiatry, 48(10), 976–980.

    Article  PubMed  Google Scholar 

  • Lupien, S. J., King, S., Meaney, M. J., & McEwen, B. S. (2001). Can poverty get under your skin? Basal cortisol levels and cognitive function in children from low and high socioeconomic status. Development and Psychopathology, 13(3), 653–676.

    Article  Google Scholar 

  • McEwen, B. S. (1998). Protective and damaging effects of stress mediators. The New England Journal of Medicine, 338, 171–179.

    Article  PubMed  Google Scholar 

  • Miller, G. E., Chen, E., & Zhou, E. S. (2007). If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychological Bulletin, 133, 25–45.

    Article  PubMed  Google Scholar 

  • Moss, H. B., Vanukov, M. M., & Martin, C. S. (1995). Salivary cortisol responses and the risk for substance abuse in prepubertal boys. Biological Psychiatry, 38, 547–555.

    Article  PubMed  Google Scholar 

  • Moss, H. B., Vanukov, M. M., Yao, J. K., & Kirilova, G. P. (1999). Salivary cortisol responses in prepubertal boys: The effects of parental substance abuse and association with drug use behavior during adolescence. Biological Psychiatry, 45, 1293–1299.

    Article  PubMed  Google Scholar 

  • Ohannessian, C. M. (2012). Parental problem drinking and adolescent psychosocial adjustment: The mediating role of adolescent–parent communication. Journal of Research on Adolescence, 22(3), 498–511.

    Article  Google Scholar 

  • Ohannessian, C. M., & Hesselbrock, V. M. (2004). Do alcohol expectancies moderate the relationship between parental alcoholism and adult drinking behaviors? Addictive Behaviors, 29(5), 901–909.

    Article  PubMed  Google Scholar 

  • Ohannessian, C. M., Hesselbrock, V. M., Kramer, J., Kuperman, S., Bucholz, K. K., Schuckit, M. A., & Nurnberger, J. I, Jr. (2004). The relationship between parental alcoholism and adolescent psychopathology: A systematic examination of parental comorbid psychopathology. Journal of Abnormal Child Psychology, 32(5), 519–533.

    Article  PubMed  Google Scholar 

  • Pelham, W. E., Lang, A. R., Atkeson, B., Murphy, D. A., Gnagy, E. M., Greiner, A. R., et al. (1997). Effects of deviant child behavior on parental distress and alcohol consumption in laboratory interactions. Journal of Abnormal Child Psychology, 25, 413–424.

    Article  PubMed  Google Scholar 

  • Petersen, A., Crockett, L., Richards, M., & Boxer, M. P. (1988). A self-report measure of pubertal status: Reliability, validity, and initial norms. Journal of Youth and Adolescence, 17, 117–133.

    Article  PubMed  Google Scholar 

  • Royston, P., Altman, D. G., & Sauerbrei, W. (2006). Dichotomizing continuous predictors in multiple regression: A bad idea. Statistics in Medicine, 25, 127–141.

    Article  PubMed  Google Scholar 

  • Saunders, J. B., Asaland, O. G., Babor, T. F., & de la Fuente, J. R. (1993). Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption: II. Addiction, 86, 791–804.

    Article  Google Scholar 

  • Sobel, M. E. (1982). Asymptotic confidence intervals for indirect effects in structural equation models. In S. Leinhardt (Ed.), Sociological methodology, 13, 290–312.

  • Sondeijker, F. E. P. L., Ferdinand, R. F., Oldehinkel, A. J., Veenstra, R., Tiemeier, H., Ormel, J., & Verhulst, F. C. (2007). Disruptive behaviors and HPA-axis activity in young adolescent boys and girls from the general population. Journal of Psychiatric Research, 41, 570–578.

    Article  PubMed  Google Scholar 

  • Sorocco, K. H., Lovallo, W. R., Vincent, A. S., & Collins, F. L. (2006). Blunted hypothalamic-pituitary-adrenocortical axis responsivity to stress in persons with a family history of alcoholism. International Journal of Psychophysiology, 59, 210–217.

    Article  PubMed Central  PubMed  Google Scholar 

  • Straus, M. A. (1979). Measuring intrafamily conflict and violence: The conflict tactics (CT) scales. Journal of Marriage And The Family, 41(1), 75–88.

    Article  Google Scholar 

  • Sturge-Apple, M. L., Davies, P. T., Cicchetti, D., & Manning, L. G. (2012). Interparental violence, maternal emotional unavailability and children’s cortisol functioning in family contexts. Developmental Psychology, 48(1), 237–249.

    Article  PubMed Central  PubMed  Google Scholar 

  • Taylor, Z. E., Spinrad, T. L., VanSchyndel, S. K., Eisenberg, N., Huynh, J., Sulik, M. J., & Granger, D. A. (2012). Sociodemographic risk, parenting, and effortful control: Relations to salivary alpha-amylase and cortisol in early childhood. Developmental Psychobiology, 55, 869–890.

  • Thayer, J. F., Hall, M., Sollers, J. J., & Fischer, J. E. (2006). Alcohol use, urinary control, and heart rate variability in apparently healthy men: Evidence for impaired inhibitory control of the HPA axis in heavy drinkers. International Journal of Psychophysiology, 59, 244–250.

    Article  PubMed  Google Scholar 

  • Windle, M. (1997). Parental alcohol experiences scale. Unpublished manuscript. Research Institute on Addictions, Buffalo, NY.

  • Zapolski, T. C., Pedersen, S. L., McCarthy, D. M., & Smith, G. T. (2013). Less drinking, yet more problems: Understanding African American drinking and related problems.

  • Zhou, Q., King, K. M., & Chassin, L. (2006). The roles of familial alcoholism and adolescent family harmony in young adults’ substance dependence disorders: Mediated and moderated relations. Journal of Abnormal Psychology, 115(2), 320–331.

    Article  PubMed  Google Scholar 

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Acknowledgments

This study was partially funded by the University of Kentucky Center for Research on Violence Against Women. Support was also provided by Grant Numbers UL1RR033173 [TL1 RR033172, KL2 RR033171] from the National Center for Research Resources (NCRR), funded by the Office of the Director, National Institutes of Health (NIH) and supported by the NIH Roadmap for Medical Research.

Conflicts of interest

In the interest of full disclosure, DAG is founder and Chief Strategy and Scientific Advisor at Salimetrics LLC (State College, PA) and SalivaBio LLC (Baltimore, MD). DAG’s relationships with these entities are managed by the policies of the Office of Research Integrity and Assurance at Arizona State University.

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Correspondence to Peggy S. Keller.

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Keller, P.S., Granger, D.A., Tyler, J. et al. Parental Problem Drinking is Associated with Children’s Adrenocortical Reactivity to Stress. J Child Fam Stud 24, 3145–3153 (2015). https://doi.org/10.1007/s10826-015-0118-6

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