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The Role of Long-Range Forces in Porin Channel Conduction

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Abstract

A fully self-consistent 3D Poisson P3M Brownian dynamics solver is used to investigate the role of the long-range electrostatic forces on the selectivity and conductivity of OmpF porin. Our simulations show that even with zero applied bias, the long-range interactions are an important component of the total potential energy. In addition, the long-range force due to mobile carriers is shown to play a role in facilitating the flow of anions through the OmpF channel by screening the effect of the negative fixed charge of the protein.

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Authors and Affiliations

  1. Electrical and Computer Engineering Department, Worcester Polytechnic Institute, Worcester, MA, 01609

    Shela Aboud

  2. Electrical and Computer Engineering Department, Illinois Institute of Technology, Chicago, IL, 60616

    David Marreiro & Marco Saraniti

  3. Molecular Biophysics Department, Rush University, Chicago, IL, 60612

    Robert Eisenberg

Authors
  1. Shela Aboud
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  2. David Marreiro
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  3. Marco Saraniti
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  4. Robert Eisenberg
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Correspondence to Shela Aboud.

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Aboud, S., Marreiro, D., Saraniti, M. et al. The Role of Long-Range Forces in Porin Channel Conduction. J Comput Electron 4, 175–178 (2005). https://doi.org/10.1007/s10825-005-7133-6

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  • DOI: https://doi.org/10.1007/s10825-005-7133-6

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