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Perinatal outcomes in 13,626 singleton pregnancies after autologous IVF across three continents over 7 years

  • Assisted Reproduction Technologies
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Abstract

Purpose

Are trends in singleton autologous IVF perinatal outcomes consistent over time among five international infertility centers?

Methods

This was a retrospective cohort study from January 1, 2012, to December 31, 2018. This study was performed through a large infertility network at five international infertility centers in which patients who had a singleton live birth resulting from fresh and frozen autologous IVF cycles were included. The primary outcome was live birth weight (BW) with secondary outcomes of preterm birth (PTB), large for gestational age (LGA), small for gestational age (SGA), and gestational age at delivery.

Results

The entire cohort (n = 13,626) consisted of 6941 fresh and 6685 frozen autologous IVF cycles leading to singleton deliveries. Maternal age, parity, body mass index, neonatal sex, and GA at delivery were similar for fresh and frozen IVF cycles in the entire cohort and within each infertility center. Four centers had a trend of decreased BW and three centers had decreased rates of PTB before 32 and 28 weeks and LGA newborns annually, although significance was not reached. Three IVF centers had annual increased trends of PTB before 37 weeks and four centers had increased rates of SGA newborns, although significance was not reached.

Conclusion

Similar trends in perinatal outcomes were present across five international infertility centers over 7 years. Additional studies are crucial to further assess and optimize perinatal outcomes at an international level.

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Acknowledgements

Authors would like to acknowledge Teresa Lopez-Rovira, Rita Vassena, Desiree Garcia, Montserrat Sabaté Lapuyade, Vanessa Pérez Martínez, Begoña Anguita Bustamante, José Roberto Alegretti, Eduardo Motta, and Daniel Duvall for local study support.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Jaimin S. Shah

  2. Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA

    Jaimin S. Shah

  3. Boston IVF – Eugin Group, 130 Second Ave, Waltham, MA, 02451, USA

    Jaimin S. Shah & Denny Sakkas

  4. Current address: Shady Grove Fertility, 2255 E Mossy Oaks Rd, Suite 620, Spring, Houston, TX, 77389, USA

    Jaimin S. Shah

  5. Department of Maternal-Fetal Medicine, BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine, Hospital Clínic, Universitat de Barcelona, 08950, Barcelona, Spain

    Francesc Figueras

  6. Eugin, 08029, Barcelona, Spain

    Anna Blàzquez & Sarai Brazal

  7. Biogenesi Reproductive Medicine Centre – Gruppo Eugin, Istituti Clinici Zucchi, Monza, Italy

    Jose Buratini, Mariabeatrice Dal Canto, Roberta Iemmello & Mario Mignini Renzini

  8. FecunMed – Eugin Group, Granollers, Spain

    Rafael Buscà & Maider Ripero

  9. Huntington Medicina Reproductiva – Eugin Group, São Paulo, SP, Brazil

    Catherine K. Jacobs & Aline R. Lorenzon

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  1. Jaimin S. Shah
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  2. Francesc Figueras
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Contributions

All authors contributed to the conceptualization of the idea and study design, data collection, critical revision of the manuscript, data interpretation, and approved the final draft of the manuscript. F.F. performed the analysis and J.S.S. drafted the manuscript.

Corresponding authors

Correspondence to Jaimin S. Shah or Denny Sakkas.

Ethics declarations

Ethics approval

This research study was conducted retrospectively from data obtained for clinical purposes. We consulted with the IRB at each institution and our study did not require ethical approval. IRB waivers of ethical approval were granted from the Committee on Clinical Investigations at Beth Israel Deaconess Medical Center (Boston), CEIM of EUGIN (Barcelona, FecunMed-Granollers), Ethical Committee of the Province of Monza Brianza (Italy), and Ethics in Research Committee/National Committee of Ethics in Research (Brazil).

Conflict of interest

FF received fees for statistical analysis of the current work. DS is on the speaker panel of EMD Serono and is Deputy Editor of Human Reproduction.

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Shah, J.S., Figueras, F., Blàzquez, A. et al. Perinatal outcomes in 13,626 singleton pregnancies after autologous IVF across three continents over 7 years. J Assist Reprod Genet 40, 2649–2657 (2023). https://doi.org/10.1007/s10815-023-02931-8

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  • DOI: https://doi.org/10.1007/s10815-023-02931-8

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