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Comparison of 1-year cumulative live birth and perinatal outcomes following single blastocyst transfer with or without preimplantation genetic testing for aneuploidy: a propensity score-matched study

  • Assisted Reproduction Technologies
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Abstract

Purpose

We evaluated whether preimplantation genetic testing for aneuploidy (PGT-A) could increase the cumulative live birth rate (CLBR) in patients with recurrent implantation failure (RIF) and recurrent pregnancy loss (RPL).

Methods

The clinical records of 7,668 patients who underwent oocyte retrieval (OR) with or without PGT-A were reviewed for 365 days and retrospectively analyzed. Using propensity score matching, 579 patients in the PGT-A group were matched one-to-one with 7,089 patients in the non-PGT-A (control) group. Their pregnancy and perinatal outcomes and CLBRs were statistically compared.

Results

The live birth rate per single vitrified-warmed blastocyst transfers (SVBTs) significantly improved in the PGT-A group in all age groups (P < 0.0002, all). Obstetric and perinatal outcomes were comparable between both groups regarding both RIF and RPL cases. Cox regression analysis demonstrated that in the RIF cases, the risk ratio per OR was significantly lower in the PGT-A group than in the control group (P = 0.0480), particularly in women aged < 40 years (P = 0.0364). However, the ratio was comparable between the groups in RPL cases. The risk ratio per treatment period was improved in the PGT-A group in both RIF and RPL cases only in women aged 40–42 years (P = 0.0234 and P = 0.0084, respectively).

Conclusion

Increased CLBR per treatment period was detected only in women aged 40–42 years in both RIF and RPL cases, suggesting that PGT-A is inappropriate to improve CLBR per treatment period in all RIF and RPL cases.

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Data availability

The primary data for this study are available from the authors on direct request.

Code availability

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The authors did not receive support from any organization for the submitted work.

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Author notes

  1. Keiichi Kato and Kenji Ezoe contributed equally to this manuscript

Authors and Affiliations

  1. Kato Ladies Clinic, Tokyo, Japan

    Keiichi Kato, Kenji Ezoe, Sachie Onogi, Shiho Ito, Rie Egawa, Naoki Aoyama & Tomoko Kuroda

  2. Department of Obstetrics and Gynaecology, Tokushima University, Tokushima, Japan

    Akira Kuwahara, Takeshi Iwasa & Minoru Irahara

  3. Takeshita Ladies Clinic, Tokyo, Japan

    Toshiyuki Takeshita

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  1. Keiichi Kato
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Contributions

Keiichi Kato and Kenji Ezoe contributed to the study design, data collection, interpretation writing and revision. Sachie Onogi, Shiho Ito, Rie Egawa, and Naoki Aoyama contributed to data collection. Tomoko Kuroda contributed to the data collection, interpretation, and manuscript revision. Akira Kuwahara, Takeshi Iwasa, Toshiyuki Takeshita, and Minoru Irahara contributed to manuscript revision. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Keiichi Kato.

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Ethics approval

The study was approved by the Institutional Review Board of the Kato Ladies Clinic (approval numbers: 19–7, 19–9).

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Written informed consent for the retrospective analysis of de-identified data was obtained from patients undergoing in vitro fertilization treatment at the center.

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Kato, K., Ezoe, K., Onogi, S. et al. Comparison of 1-year cumulative live birth and perinatal outcomes following single blastocyst transfer with or without preimplantation genetic testing for aneuploidy: a propensity score-matched study. J Assist Reprod Genet 40, 2669–2680 (2023). https://doi.org/10.1007/s10815-023-02926-5

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