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Sociocultural imperatives for Singapore to permit preimplantation genetic testing-aneuploidy (PGT-A) despite uncertain results and ongoing controversy

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References

  1. Zheng Z, Tan J, Chen L, Liu S, Zhou C, Li Y. PGT-A improved singleton live birth rate among all age groups of women who underwent elective single blastocyst transfer: a single-centre retrospective study. J Assist Reprod Genet. 2023. https://doi.org/10.1007/s10815-023-02775-2.

    Article  PubMed  Google Scholar 

  2. Kucherov A, Fazzari M, Lieman H, Ball GD, Doody K, Jindal S. PGT-A is associated with reduced cumulative live birth rate in first reported IVF stimulation cycles age ≤ 40: an analysis of 133,494 autologous cycles reported to SART CORS. J Assist Reprod Genet. 2023;40(1):137–49.

    Article  PubMed  Google Scholar 

  3. Mochizuki L, Gleicher N. The PGS/PGT-A controversy in IVF addressed as a formal conflict resolution analysis. J Assist Reprod Genet. 2020;37(3):677–87.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Barad DH, Albertini DF, Gleicher N. In science truth ultimately wins, and PGT-A is no exception. Hum Reprod. 2022;37(9):2216–8.

    Article  CAS  PubMed  Google Scholar 

  5. He X, Wang X, Shen J, Wan B, Wang Y, Zhang Z, Cai L, Bao Y, Ding H, Li X. Cost-effectiveness of preimplantation genetic testing for aneuploidy for women with subfertility in China: an economic evaluation using evidence from the CESE-PGS trial. BMC Pregnancy Childbirth. 2023;23(1):254.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Lee M, Lofgren KT, Thomas A, Lanes A, Goldman R, Ginsburg ES, Hornstein MD. The cost-effectiveness of preimplantation genetic testing for aneuploidy in the United States: an analysis of cost and birth outcomes from 158,665 in vitro fertilization cycles. Am J Obstet Gynecol. 2021;225(1):55.e1-55.e17.

    Article  PubMed  Google Scholar 

  7. Singapore Parliament. Oral Answers to Questions: Increasing number of patients and subsidy for pre-implantation genetic screening. Singapore Parliament Website, 2nd March 2021. Accessible at: https://sprs.parl.gov.sg/search/#/sprs3topic?reportid=oral-answer-2421 (Date accessed: 29th April 2023).

  8. Teo J. S’pore couples get help to pay for tests to cut risk of passing on genetic diseases in IVF. The Straits Times, 1st July 2022. Accessible at: https://www.straitstimes.com/singapore/health/spore-couples-get-help-to-pay-for-tests-to-cut-risk-of-passing-on-genetic-diseases-in-ivf (Date accessed: 29th April 2023).

  9. Gleicher N, Albertini DF, Barad DH, Homer H, Modi D, Murtinger M, Patrizio P, Orvieto R, Takahashi S, Weghofer A, Ziebe S, Noyes N; International Do No Harm Group in IVF (IDNHG-IVF). The 2019 PGDIS position statement on transfer of mosaic embryos within a context of new information on PGT-A. Reprod Biol Endocrinol. 2020;18(1):57.

  10. Chan C, Ryu M, Zwingerman R. Preimplantation genetic testing for aneuploidy: A Canadian Fertility and Andrology Society Guideline. Reprod Biomed Online. 2021;42(1):105–16.

    Article  CAS  PubMed  Google Scholar 

  11. Ng A. Singapore's total fertility rate drops to historic low of 1.05. Channel News Asia, 24th February 2023. Accessible at: https://www.channelnewsasia.com/singapore/singapore-total-fertility-rate-population-births-ageing-parents-children-3301846 (Date accessed: 29th April 2023).

  12. Teo J. S'pore couples get help to pay for tests to cut risk of passing on genetic diseases in IVF. The Straits Times, 1st July 2022. Accessible at: https://www.straitstimes.com/singapore/health/spore-couples-get-help-to-pay-for-tests-to-cut-risk-of-passing-on-genetic-diseases-in-ivf (Date accessed: 18th May 2023).

  13. Singapore Department of Statistics. Census of Population 2020 - Religion. Accessible at: https://www.singstat.gov.sg/-/media/files/visualising_data/infographics/c2020/c2020-religion.ashx (Date accessed: 29th April 2023).

  14. Tan SH. Religion in the abortion discourse in Singapore: a case study of the relevance of religious arguments in law-making in multi-religious democracies. J Law  Relig. 2010;26(2):505–39.

    Article  Google Scholar 

  15. Heng A. Risky and unnecessary embryo genetic testing (PGT-A) in Malaysia is driven by culture. Bioedge, 25th April 2023. Accessible at: https://bioedge.org/beginning-of-life-issues/ivf/risky-and-unnecessary-embryo-genetic-testing-pgt-a-in-malaysia-is-driven-by-culture/ (Date accessed: 29th April 2023).

  16. Avery K. Disability and the Three Traditional Chinese Belief Systems. China Source, 7th March 2016. Accessible at: https://www.chinasource.org/resource-library/articles/disability-and-the-three-traditional-chinese-belief-systems/ (Date accessed: 29th April 2023).

  17. Litwinska E, Litwinska M, Czuba B, Gach A, Kwiatkowski S, Kosinski P, Kaczmarek P, Wielgos M. Amniocentesis in Twin Pregnancies: Risk Factors of Fetal Loss. J Clin Med. 2022;11(7):1937.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Gil MM, Rodríguez-Fernández M, Elger T, Akolekar R, Syngelaki A, De Paco MC, Molina FS, Gallardo Arocena M, Chaveeva P, Persico N, Accurti V, Kagan KO, Prodan N, Cruz J, Nicolaides KH. Risk of fetal loss after chorionic villus sampling in twin pregnancy derived from propensity score matching analysis. Ultrasound Obstet Gynecol. 2022;59(2):162–8.

    Article  CAS  PubMed  Google Scholar 

  19. Orvieto R, Shimon C, Rienstein S, Jonish-Grossman A, Shani H, Aizer A. Do human embryos have the ability of self-correction? Reprod Biol Endocrinol. 2020;18(1):98.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Coticchio G, Barrie A, Lagalla C, Borini A, Fishel S, Griffin D, Campbell A. Plasticity of the human preimplantation embryo: developmental dogmas, variations on themes and self-correction. Hum Reprod Update. 2021;27(5):848–65.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Singapore Fertility and IVF Consultancy Pvt Ltd., 531A Upper Cross Street, #04-95, Hong Lim Complex, Singapore, 051531, Singapore

    Alexis Heng Boon Chin

  2. Center for Reproductive Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

    Ningyu Sun

Authors
  1. Alexis Heng Boon Chin
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  2. Ningyu Sun
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Correspondence to Alexis Heng Boon Chin.

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Chin, A.H.B., Sun, N. Sociocultural imperatives for Singapore to permit preimplantation genetic testing-aneuploidy (PGT-A) despite uncertain results and ongoing controversy. J Assist Reprod Genet 40, 1377–1379 (2023). https://doi.org/10.1007/s10815-023-02836-6

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