Skip to main content
SpringerLink
Log in

Successful ART outcome with donor oocytes in female Kartagener’s syndrome: a case report and follow-up

  • Assisted Reproduction Technologies
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

A 30-year-old woman presented with history of primary infertility of 8 years and multiple failed intrauterine insemination (IUI) attempts. She had the classic symptoms of Kartagener’s syndrome—situs inversus, chronic sinusitis, and bronchiectasis. She had polycystic ovarian disease (PCOD) with regular menstrual cycles. Her karyotyping was normal. There was no other significant history including surgeries and the marriage was non-consanguineous. Her partner was 34 years old with normal semen and hormonal parameters. Her first intra-cytoplasmic sperm injection (ICSI) cycle with her own oocytes and husband’s sperm resulted in a pregnancy but she suffered a miscarriage at 11 weeks. Her second attempt with donor oocytes and husband’s sperm resulted in a pregnancy again but she miscarried at 9 weeks. The third attempt with a frozen embryo transfer with supernumerary embryos resulted in a pregnancy and she delivered a live female baby who was followed up for 8 years. This is the first report of a patient with KS undergoing assisted reproduction technologies (ART) treatment with donor oocytes. This is also the first Indian report of a female KS patient undergoing ART treatment with donor oocytes. IUI may not be the ideal treatment option in female patients with KS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ul Hassan A, Hassan G, Khan SH, Rasool Z, Abida A. Ciliopathy with special emphasis on Kartagener’s syndrome. Int J Health Sci. 2009;3(1):65–9.

    Google Scholar 

  2. Zariwala MA, Knowles MR, Omran H. Genetic defects in ciliary structure and function. Annu Rev Physiol. 2007;69:423–50. https://doi.org/10.1146/annurev.physiol.69.040705.141301.

    Article  CAS  PubMed  Google Scholar 

  3. “Primary ciliary dyskinesia.” National Organization for Rare Disorders. 2020. https://rarediseases.org/rare-diseases/primary-ciliary-dyskinesia/?filter=complete-report. Accessed 19 Jan 2023.

  4. O’Callaghan C, Chetcuti P, Moya E. High prevalence of primary ciliary dyskinesia in a British Asian population. Arch Dis Child. 2010;95(1):51–2. https://doi.org/10.1136/adc.2009.158493.

    Article  PubMed  Google Scholar 

  5. Afzelius BA. A human syndrome caused by immotile cilia. N Y Sci J. 1976;193(4250):317–9. https://doi.org/10.1126/science.1084576.

    Article  CAS  Google Scholar 

  6. Goutaki M, Meier AB, Halbeisen FS, et al. Clinical manifestations in primary ciliary dyskinesia: systematic review and meta-analysis. Eur Respir J. 2016;48(4):1081–95. https://doi.org/10.1183/13993003.00736-2016.

    Article  PubMed  Google Scholar 

  7. Blyth M, Wellesley D. Ectopic pregnancy in primary ciliary dyskinesia. J Obstet Gynaecol. 2008;28(3):358. https://doi.org/10.1080/01443610802058742.

    Article  CAS  PubMed  Google Scholar 

  8. Raidt J, Werner C, Menchen T, et al. Ciliary function and motor protein composition of human fallopian tubes. Hum Reprod. 2015;30(12):2871–80. https://doi.org/10.1093/humrep/dev227.

    Article  CAS  PubMed  Google Scholar 

  9. Vanaken GJ, Bassinet L, Boon M, et al. Infertility in an adult cohort with primary ciliary dyskinesia: phenotype-gene association. Eur Respir J. 2017;50(5):1700314. https://doi.org/10.1183/13993003.00314-2017.

    Article  CAS  PubMed  Google Scholar 

  10. Halbert SA, Patton DL, Zarutskie PW, Soules MR. Function and structure of cilia in the fallopian tube of an infertile woman with Kartagener’s syndrome. Hum Reprod. 1997;12(1):55–8. https://doi.org/10.1093/humrep/12.1.55.

    Article  CAS  PubMed  Google Scholar 

  11. Lin TK, Kuo-Kuang Lee R, Su JT, et al. A successful pregnancy with in vitro fertilization and embryo transfer in an infertile woman with Kartagener’s syndrome: a case report. J Assist Reprod Genet. 1998;15:625–7. https://doi.org/10.1023/A:1020341629516.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ceccaldi PF, Carré-Pigeon F, Youinou Y, et al. Syndrome de Kartagener et stérilité: observation, diagnostic et priseen charge [Kartagener’s syndrome and infertility: observation, diagnosis and treatment]. J Gynecol Obstet Biol Reprod (Paris). 2004;33(3):192–4. https://doi.org/10.1016/s0368-2315(04)96439-3.

    Article  PubMed  Google Scholar 

  13. Barthwal MS. Kartagener’s syndrome in a fertile male – an uncommon variant. Lung India. 2006;23(3):123–5. https://doi.org/10.4103/0970-2113.44404.

    Article  Google Scholar 

  14. Jayasena CN, Sironen A. Diagnostics and management of male infertility in primary ciliary dyskinesia. Diagnostics. 2021;11(9):1550. https://doi.org/10.3390/diagnostics11091550.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Jain S, Kotarba D, Leader A. Spontaneous intrauterine pregnancy in a woman with both Kartagener’s syndrome and polycystic ovarian disease—a case report. Fertil Steril. 2003;80:139–139. https://doi.org/10.1016/S0015-0282(03)01247-0.

    Article  Google Scholar 

  16. Zhang X, Chen D, You Y, Peng B. Successful pregnancy in patient with Kartagener’s syndrome and infertility: case report and published work review. Clin Exp Obstet Gynecol. 2018;45(5):791–3. https://doi.org/10.12891/ceog4287.2018.

    Article  Google Scholar 

  17. Fliegauf M, Benzing T, Omran H. When cilia go bad: cilia defects and ciliopathies. Nat Rev Mol Cell Biol. 2007;8(11):880–93. https://doi.org/10.1038/nrm2278.

    Article  CAS  PubMed  Google Scholar 

  18. Afzelius BA, Eliasson R. Male and female infertility problems in the immotile-cilia syndrome. Eur J Respir Dis Suppl. 1983;127:144–7.

    CAS  PubMed  Google Scholar 

  19. Lyons RA, Saridogan E, Djahanbakhch O. The reproductive significance of human Fallopian tube cilia. Hum Reprod Update. 2006;12(4):363–72. https://doi.org/10.1093/humupd/dml012.

    Article  CAS  PubMed  Google Scholar 

  20. Ezzati M, Djahanbakhch O, Arian S, Carr BR. Tubal transport of gametes and embryos: a review of physiology and pathophysiology. J Assist Reprod Genet. 2014;31(10):1337–47. https://doi.org/10.1007/s10815-014-0309-x.

    Article  PubMed  PubMed Central  Google Scholar 

  21. McComb P, Langley L, Villalon M, Verdugo P. The oviductal cilia and Kartagener’s syndrome. Fertil Steril. 1986;46(3):412–6.

    Article  CAS  PubMed  Google Scholar 

  22. Fliegauf M, Olbrich H, Horvath J, et al. Mislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesia. Am J Respir Crit Care Med. 2005;171(12):1343–9. https://doi.org/10.1164/rccm.200411-1583OC.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Werner C, Onnebrink JG, Omran H. Diagnosis and management of primary ciliary dyskinesia. Cilia. 2015;4:2. https://doi.org/10.1186/s13630-014-0011-8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Eliyahu S, Shalev E. A fertile woman with Kartagener’s syndrome and three consecutive pregnancies. Hum Reprod. 1996;11(3):683. https://doi.org/10.1093/humrep/11.3.683.

    Article  CAS  PubMed  Google Scholar 

  25. Green MP, Mouat F, Miles HL, et al. The phenotype of an IVF child is associated with peri-conception measures of follicular characteristics and embryo quality. Hum Reprod. 2014;29(11):2583–91. https://doi.org/10.1093/humrep/deu221.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Crea Conceptions, Kattupakkam, Chennai, Tamil Nadu, India

    Sasikala Natarajamani, Rajapriya Ayyappan & Archana Manikere

Authors
  1. Sasikala Natarajamani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rajapriya Ayyappan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Archana Manikere
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sasikala Natarajamani.

Ethics declarations

Informed consent

The participant has consented to the submission of the case report to the journal.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Natarajamani, S., Ayyappan, R. & Manikere, A. Successful ART outcome with donor oocytes in female Kartagener’s syndrome: a case report and follow-up. J Assist Reprod Genet 40, 779–782 (2023). https://doi.org/10.1007/s10815-023-02794-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10815-023-02794-z

Keywords

Search

Navigation