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The prospects of cell therapy for endometriosis

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Abstract

Endometriosis is a chronic inflammatory estrogen-dependent disease characterized by the growth of endometrial-like tissue outside the physiological region. Despite the fact that this disease is common, laparoscopic surgery is currently the gold standard in the treatment of endometriosis. In this regard, it is necessary to develop new effective methods of minimally invasive therapy for endometriosis. One of the promising areas in the treatment of endometriosis is cell therapy. Cellular therapy is a vast branch of therapeutic methods with various agents. Potential cell therapies for endometriosis may be based on the principle of targeting aspects of the pathogenesis of the disease: suppression of estrogen receptor activity, angiogenesis, fibrosis, and a decrease in the content of stem cells in endometriosis foci. In addition, immune cells such as NK cells and macrophages may be promising agents for cell therapy of endometriosis. Standing apart in the methods of cell therapy is the replacement therapy of endometriosis. Thus, many studies in the field of the pathogenesis of endometriosis can shed light not only on the causes of the disease and may contribute to the development of new methods for personalized cell therapy of endometriosis.

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Funding

Part of the work concerning endometriosis was supported by a grant for young Russian scientists MK-1573.2022.3. This paper has been supported by the PFUR University Strategic Academic Leadership Program. Part of the work concerning macrophages was supported by Russian Science Foundation [grant number 22-14-00152].

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Authors and Affiliations

  1. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of Surgery”, Moscow, Russia

    Daria Artemova, Elena Gantsova & Andrey Elchaninov

  2. Research Institute of Molecular and Cellular Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

    Daria Artemova, Polina Vishnyakova, Elena Gantsova, Andrey Elchaninov & Timur Fatkhudinov

  3. National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, Moscow, Russia

    Polina Vishnyakova, Andrey Elchaninov, Timur Fatkhudinov & Gennady Sukhikh

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Daria Artemova, Polina Vishnyakova, Elena Gantsova, Andrey Elchaninov, Timur Fatkhudinov, Gennady Sukhikh had the idea for the article. Daria Artemova, Polina Vishnyakova performed the literature search and data analysis. Daria Artemova, Polina Vishnyakova, Elena Gantsova, Andrey Elchaninov drafted the manuscript. All authors reviewed and approved the final version of the manuscript.

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Correspondence to Timur Fatkhudinov.

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Artemova, D., Vishnyakova, P., Gantsova, E. et al. The prospects of cell therapy for endometriosis. J Assist Reprod Genet 40, 955–967 (2023). https://doi.org/10.1007/s10815-023-02772-5

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