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BRCA, infertility, and fertility preservation: a review for counseling


BRCA mutations as a triggering factor in breast cancer have been reported to result in fertility problems and oocyte aging in young patients with cancer diagnosis. These patients are concerned about fertility problems and family planning before undergoing treatment modalities that may result in infertility. In this review, we conducted analysis of the literature on the association between BRCA mutations and infertility, possible fertility preservation options, and their safety and tried to gather results from different disciplines and points of view on the matter. Our aim is to provide a general summary of recent studies to provide further insight on the matter for counseling BRCA mutation carriers on fertility preservation methods and their implications.

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BReast CAncer gene


Deoxyribonucleic acid


Double-strand break


Meiotic recombination 11 homolog A




Nijmegen breakage syndrome 1


Ataxia telangiectasia mutated


Ataxia telangiectasia and Rad3 related


H2A histone family member X


Mediator of DNA damage checkpoint 1


Checkpoint kinase 2


Tumor suppressor p53-binding protein 1


DNA meiotic recombinase 1


Anti-Müllerian hormone


Homologous recombination


Non-homologous end joining


Assisted reproductive techniques


Fertility preservation


In vitro fertilization


Pre-implantation genetic diagnosis


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Correspondence to Feride İffet Şahin.

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Baltacı, E., Kazancı, F. & Şahin, F.İ. BRCA, infertility, and fertility preservation: a review for counseling. J Assist Reprod Genet 40, 465–472 (2023).

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  • BRCA1
  • BRCA2
  • Infertility
  • Fertility preservation
  • Breast cancer
  • Genetic counseling