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The association of obesity with euploidy rates in women undergoing in vitro fertilization with preimplantation genetic testing

Journal of Assisted Reproduction and Genetics volume 39, pages 2521–2528 (2022)Cite this article

Abstract

Purpose

The purpose of this study was to determine the impact of body mass index (BMI) on euploidy rates for in vitro fertilization (IVF) cycles with preimplantation genetic testing (PGT) utilizing primarily next-generation sequencing (NGS).

Methods

This retrospective cohort study included women aged ≤ 45 years who underwent IVF/PGT between September 2013 and September 2020 at a single university-affiliated fertility center. The primary outcome was euploidy rate. Secondary outcomes included peak serum estradiol (E2), number of oocytes retrieved, oocyte maturation rate, high-quality blastulation rate, clinical loss rate (CLR), clinical pregnancy rate (CPR), and ongoing pregnancy/live birth rate (OPR/LBR).

Results

The study included 1335 IVF cycles that were stratified according to BMI (normal, n = 648; overweight, n = 377; obese, n = 310). The obese group was significantly older with significantly lower baseline FSH, peak E2, high-quality blastulation rate, and number of embryos biopsied than the normal group. Overall euploidy rates were not significantly different between BMI groups (normal 36.4% ± 1.3; overweight 37.3% ± 1.8; obese 32.3% ± 1.8; p = 0.11), which persisted after controlling for covariates (p = 0.82) and after stratification of euploidy rate by age group and by number of oocytes retrieved per age group. There were no significant differences in CLR, CPR, and OPR/LBR across BMI groups.

Conclusions

Despite a lower high quality blastulation rate with obesity, there is not a significant difference in euploidy rates across BMI groups in women undergoing IVF/PGT.

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Fig. 1

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Authors and Affiliations

  1. Center for Advanced Reproductive Services, Division of Reproductive Endocrinology & Infertility, University of Connecticut Health Center, 2 Batterson Park Rd, Farmington, CT, 06032, USA

    Stephanie Hallisey, Reeva Makhijani, Prachi Godiwala, John Nulsen, Claudio Benadiva, Daniel Grow & Lawrence Engmann

  2. Reproductive Medicine Associates of Philadelphia, 1015 Chestnut Street, 8th Floor, Philadelphia, PA, 19107, USA

    Jeffrey Thorne

Authors
  1. Stephanie Hallisey
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  2. Reeva Makhijani
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  3. Jeffrey Thorne
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  4. Prachi Godiwala
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  5. John Nulsen
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  7. Daniel Grow
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Correspondence to Lawrence Engmann.

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Hallisey, S., Makhijani, R., Thorne, J. et al. The association of obesity with euploidy rates in women undergoing in vitro fertilization with preimplantation genetic testing. J Assist Reprod Genet 39, 2521–2528 (2022). https://doi.org/10.1007/s10815-022-02624-8

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  • DOI: https://doi.org/10.1007/s10815-022-02624-8

Keywords

  • In vitro fertilization
  • Preimplantation genetic testing
  • Euploidy rate
  • Body mass index