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Analysis of IVF/ICSI outcomes in infertile women with early-stage endometrial cancer and atypical endometrial hyperplasia after conservative treatment

  • Assisted Reproduction Technologies
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Abstract

Purpose

To investigate the in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes and identify factors that might affect live births in patients with early-stage endometrial cancer (EEC) and atypical endometrial hyperplasia (AEH).

Methods

This retrospective study was performed in a tertiary hospital. Patients (n = 123) with EEC or AEH, who underwent IVF/ICSI treatment between January 2010 and December 2019, were divided into a live birth group and a non-live birth group. Clinical characteristics and IVF/ICSI outcomes were assessed.

Results

A total of 123 patients (28 with EEC and 95 with AEH) underwent 215 ovarian stimulation cycles, resulting in 121 fresh embryo transfer (ET) and 108 frozen-thawed ET. Among 229 ET cycles, 91 (23.7%) of 384 embryos were implanted and 86 pregnancies were achieved, including five ectopic pregnancies (5.8%), 28 miscarriages (32.6%), and 53 live births (61.6%). The clinical pregnancy and live birth rates in each ET cycle were 37.6% and 23.1%, respectively. Fifty-one patients gave birth to 57 live neonates, and the cumulative live birth rate was 41.46%. Multiple logistic regression analysis showed that maternal age, histological type, thin endometrium, and time after complete remission (CR) to IVF cycle started were significantly associated with live births.

Conclusions

The live birth rate after IVF/ICSI is promising in infertile patients with EEC and AEH. A shorter interval between CR and IVF/ICSI treatment might be a positive factor, while age > 35 years, endometrial thickness < 8 mm on the day of ET, and degree of endometrial lesion progressing into carcinoma can negatively influence IVF/ICSI outcomes.

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Data availability

All data generated and analyzed during this study are available from the corresponding author on reasonable request.

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Acknowledgements

We thank all the staffs in the reproductive center of PUTH for their work for this study.

Funding

This study was supported by grants from the CAMS Innovation Fund for Medical Sciences (2019-I2M-5–001) and the National Key Research and Development Program of China (2018YFC1002101).

Author information

Author notes

  1. Yaxing Guo and Xuan Zong contributed equally to this work.

Authors and Affiliations

  1. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China

    Yaxing Guo, Xuan Zong, Hongzhen Li & Jie Qiao

  2. National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China

    Hongzhen Li & Jie Qiao

  3. Key Laboratory of Assisted Reproduction, Ministry of Education, Peking University, Beijing, 100191, China

    Hongzhen Li & Jie Qiao

  4. Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing, 100191, China

    Hongzhen Li & Jie Qiao

Authors
  1. Yaxing Guo
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  2. Xuan Zong
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  3. Hongzhen Li
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  4. Jie Qiao
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Contributions

YG, XZ, HL, and JQ developed the design of the study. YG and XZ collected the clinical data. XZ drafted the manuscript. YG contributed the data analysis. HL and JQ proofread and revised the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Jie Qiao.

Ethics declarations

Ethics approval

This study was approved by the Ethics Committee of the Peking University Third Hospital (No. IRB00006761-m2021237).

Consent to participate

Approval for a waiver for written consent was obtained from the Ethics Committee of the Peking University Third Hospital due to the retrospective nature of this study.

Consent for publication

This manuscript has not been published or presented elsewhere and is not under consideration by another journal. All study participants provided informed consent and approved it for publication.

Competing interests

The authors declare no competing interests.

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Guo, Y., Zong, X., Li, H. et al. Analysis of IVF/ICSI outcomes in infertile women with early-stage endometrial cancer and atypical endometrial hyperplasia after conservative treatment. J Assist Reprod Genet 39, 1643–1651 (2022). https://doi.org/10.1007/s10815-022-02475-3

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  • DOI: https://doi.org/10.1007/s10815-022-02475-3

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