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Live birth after in vitro maturation in women with gonadotropin resistance ovary syndrome: report of two cases

  • Reproductive Physiology and Disease
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

Gonadotropin-resistant ovary syndrome (GROS) is a rare endocrine disorder that causes hypergonadotropic hypogonadism, amenorrhea, and infertility. This study reports live birth in two women with GROS who underwent fertility treatment with in vitro maturation (IVM).

Methods

Both patients had primary infertility, amenorrhea (primary and secondary), typical secondary sexual characters, elevated gonadotropin levels, normal ovarian reserve, normal chromosomal characteristics, and previous nonresponsiveness gonadotropin stimulations. One patient had polymorphism of the follicle-stimulating hormone receptor, which is a predictor of poor ovarian response. Given unresponsiveness to exogenous gonadotropin stimulations, IVM with human chorionic gonadotropin priming (hCG-IVM) was performed in both patients. All transferrable embryos were vitrified.

Results

Both patients achieved pregnancy after their first frozen embryos transfer, and each delivered a healthy baby boy.

Conclusions

These results suggest that IVM should be a first-line therapeutic option for patients with GROS.

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Authors and Affiliations

Authors

Contributions

HLL, TTNL, and VTTT designed the study and monitored data collection. Planning for the first draft of the manuscript was undertaken by HLL. The first draft of the paper was written by HLL and VNAH. The final draft of the paper was written by HLL and LNV. All authors were involved in the decision to publish the paper and in critical revisions of the manuscript. HLL acts as overall guarantor and accepts full responsibility.

Corresponding author

Correspondence to Ho Long Le.

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LNV has received speaker and conference fees from Merck; and grant, speaker, and conference fees from Merck Sharpe & Dohme and Ferring. TMH has received speaker fees from Merck, Merck Sharp & Dohme, and Ferring. All other authors declare no competing interests.

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Le, H.L., Ho, V.N.A., Le, T.T.N. et al. Live birth after in vitro maturation in women with gonadotropin resistance ovary syndrome: report of two cases. J Assist Reprod Genet 38, 3243–3249 (2021). https://doi.org/10.1007/s10815-021-02355-2

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