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Sixth grade academic achievement among children conceived with IVF: a population-based study in Texas, USA

Abstract

Purpose

To compare academic achievement in reading and mathematics at the end of sixth grade and progress from third to sixth grade by children conceived with in vitro fertilization (IVF) to those conceived naturally.

Methods

This was a retrospective population-based cohort study of IVF-conceived singleton and twin children who took the 3rd grade and 6th grade public school standardized reading and mathematics testing in Texas.

Results

There were 6623 children with reading scores in both the third and sixth grades and 6374 children with mathematics scores in both the third and sixth grades. Mean (± SE) scaled test scores for IVF and control singleton children for reading were 1544.6 ± 3.4 and 1527.7 ± 1.9, respectively, in third grade and 1701.2 ± 3.6 and 1681.0 ± 2.0, respectively, in sixth grade; for mathematics, the scores were 1564.4 ± 3.7 and 1548.9 ± 2.1, respectively, in third grade and 1774.0 ± 4.2 and 1752.0 ± 2.3, respectively, in sixth grade. In multivariate models, singleton IVF children scored significantly higher than control children in reading and mathematics, averaging 17.7 ± 4.0 points and 20.1 ± 4.1 points higher, respectively, in reading in third and sixth grades and 17.8 ± 4.4 points and 25.0 ± 4.8 points higher, respectively, in mathematics in third and sixth grades.

Conclusions

Children conceived with IVF and aged 8–9 years and aged 10–12 years performed as well on third and sixth grade reading and mathematics assessments as their counterparts conceived naturally.

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References

  1. Luke B, Gopal D, Stern JE, Diop H. Pregnancy, birth, and infant outcomes by maternal fertility status: The Massachusetts Outcomes Study of Assisted Reproductive Technology. Am J Obstet Gynecol. 2017;217:327.e1–14. https://doi.org/10.1016/j.ajog.2017.04.006.

    Article  Google Scholar 

  2. Luke B, Brown MB, Wantman E, Seifer DB, Sparks AT, Lin PC, et al. Risk of prematurity and infant morbidity and mortality by maternal fertility status and plurality. J Assist Reprod Genet. 2019;36(1):121–38.

    PubMed  Article  Google Scholar 

  3. Pinborg A, Wennerholm UB, Romundstad LB, Loft A, Aittomaki K, Söderström-Anttila V, et al. Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Human Reproduction Update. 2013;19:87–104.

    CAS  PubMed  Article  Google Scholar 

  4. Hart R, Norman RJ. The longer-term health outcomes for children born as a result of IVF treatment. Part II-Mental health and development outcomes. Hum Reprod Update. 2013;19(3):244–50.

    CAS  PubMed  Article  Google Scholar 

  5. Rumbold AR, Moore VM, Whitrow MJ, Oswald TK, Moran LJ, Fernandez RC, et al. The impact of specific fertility treatments on cognitive development in childhood and adolescence: A systematic review. Hum Reprod. 2017;32:1489–507.

    PubMed  Article  Google Scholar 

  6. Bay B, Mortensen EL, Golombok S, Hohwü L, Obel C, Henriksen TB, et al. Long-awaited pregnancy: intelligence and academic performance in offspring of infertile parents—a cohort study. Fertility and Sterility. 2016;106:1033–40.

    PubMed  Article  Google Scholar 

  7. Berry KA, Baron IS, Weiss BA, Baker R, Ahronovich MD, Litman FR. In vitro fertilization and late preterm preschoolers’ neuropsychological outcomes: the PETIT study. Am J Obstet Gynecol. 2013;209:356.e1–6.

    Article  Google Scholar 

  8. Mains L, Zimmerman M, Blaine J, Stegmann B, Sparks A, Ansley T, et al. Achievement test performance in children conceived by IVF. Hum Reprod. 2010;25:2605–11.

    CAS  PubMed  Article  Google Scholar 

  9. Wagenaar K, Ceelen M, van Weissenbruch MM, Knol DL, Delemarre-van de Waal HA, Huisman J. School functioning in 8- to 18-year-old children born after in vitro fertilization. Eur J Pediatr. 2008;167:1289–95.

    PubMed  Article  Google Scholar 

  10. Leslie GI, Gibson FL, McMahon C, Cohen J, Saunders DM, Tennant C. Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age. Hum Reprod. 2003;18(10):2067–72.

    CAS  PubMed  Article  Google Scholar 

  11. Leunens L, Celestin-Westreich S, Bonduelle M, Liebaers I, Ponjaert-Kristoffersen I. Cognitive and motor development of 8-year-old children born after ICSI compared to spontaneously conceived children. Hum Reprod. 2006;21(11):2922–9.

    CAS  PubMed  Article  Google Scholar 

  12. Spangmose AL, Malchau SS, Henningsen AA, Forman JL, Rasmussen S, Loft A, et al. Academic performance in adolescents aged 15-16 years born after frozen embryo transfer compared with fresh embryo transfer: A nationwide registry-based study. Br J Obstet Gynaecol. 2019;126:261–9.

    CAS  Article  Google Scholar 

  13. Schendelaar P, La Bastide-Van Gemert S, Heineman MJ, et al. Subfertility factors rather than assisted conception factors affect cognitive and behavioural development of 4-year-old singletons. Reprod BioMed Online. 2016;33:752–62.

    PubMed  Article  Google Scholar 

  14. Wagenaar K, van Weissenbruch MM, Knol DL, Cohen-Kettenis PT, Delemarre-van de Waal HA, Huisman J. Information processing, attention and visual-motor function of adolescents born after in vitro fertilization compared with spontaneous conception. Hum Reprod. 2009;24(4):913–21.

    CAS  PubMed  Article  Google Scholar 

  15. Place I, Englert Y. A prospective longitudinal study of the physical, psychomotor, and intellectual development of singleton children up to 5 years who were conceived by intracytoplasmic sperm injection compared with children conceived spontaneously and by in vitro fertilization. Fertil Steril. 2003;80:1388–97.

    PubMed  Article  Google Scholar 

  16. Ludwig A, Katalinic A, Thyen U, Sutcliffe AG, Diedrich K, Ludwig M. Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmic sperm injection ICSI: Results of a prospective controlled single-blinded study in Germany. Fertil Steril. 2009;91:125–32.

    PubMed  Article  Google Scholar 

  17. Norrman E, Petzold M, Bergh C, Wennerholm U-B. School performance in singletons born after assisted reproductive technology. Hum Reprod. 2018;10:1948–59.

    Article  Google Scholar 

  18. Spangmose AL, Malchau SS, Schmidt L, Vassard D, Rasmussen S, Loft A, et al. Academic performance in adolescents born after ART—A nationwide registry-based cohort study. Hum Reprod. 2017;32(2):447–56.

    CAS  PubMed  Article  Google Scholar 

  19. Branigan AR, Helgertz J. Resolved parental infertility and children’s educational achievement. Demography. 2017;54:911–31.

    PubMed  Article  Google Scholar 

  20. Christensen K, Petersen I, Skytthe A, Herskind AM, McGue M, Bingley P. Comparison of academic performance of twins and singletons in adolescence: Follow-up study. BMJ. 2006;333:1095–7.

    PubMed  PubMed Central  Article  Google Scholar 

  21. Wienecke LS, Kjaer SK, Frederiksen K, Hargreave M, Dalton SO, Jensen A. Ninth-grade school achievement in Danish children conceived following fertility treatment: A population-based cohort study. Fertil Steril. 2020;113:1014–23.

    PubMed  Article  Google Scholar 

  22. Beauregard JL, Drews-Botsch C, Sales JM, Flanders JM, Kramer MR. Does socioeconomic status modify the association between preterm birth and children’s early cognitive ability and kindergarten academic achievement in the United States? Am J Epidemiol. 2018;187(8):1704–13.

    PubMed  PubMed Central  Article  Google Scholar 

  23. Sastry N, Pebley AR. Family and neighborhood sources of socioeconomic inequality in children’s achievement. Demography. 2010;47(3):777–800.

    PubMed  PubMed Central  Article  Google Scholar 

  24. Gogtay N, Giedd JN, Lusk L, Hayashi KM, Greenstein D, Vaituzis AC, et al. Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci. 2004;101:8174–9.

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  25. Waber DP, De Moor C, Forbes PW, et al. The NIH MRI study of normal brain development: performance of a population based sample of healthy children aged 6 to 18 on a neuropsychological battery. J Int Neuropsychol Soc. 2007;13:729–46.

    PubMed  Article  Google Scholar 

  26. Feister L. Early warning! Why reading by the end of third grade matters. Baltimore, MD: Annie E. Casey Foundation, 2010. https://www.aecf.org/resources/early-warning-why-reading-by-the-end-of-third-grade-matters/

  27. Luke B, Brown MB, Ethen M, Canfield MA, Watkins S, Wantman E, et al. Third grade academic achievement among children conceived with IVF: a population-based study in Texas, USA. Fertil Steril. 2020;113:1242–50.

    PubMed  PubMed Central  Article  Google Scholar 

  28. Centers for Disease Control and Prevention, American Society for Reproductive Medicine, and Society for Assisted Reproductive Technology. 2016 Assisted Reproductive Technology Success Rates: National Summary and Fertility Clinic Reports. Washington, DC: US Dept. of Health and Human Services, 2018. https://www.cdc.gov/art/pdf/2016-report/ART-2016-National-Summary-Report.pdf

  29. R01 CA151973, Assisted Reproductive Technology and Risk of Childhood Cancer, Barbara Luke and Logan Spector, Multiple Principal Investigators.

  30. R01 HD084377, Assisted reproduction and child health: risk of birth defects, mortality, and effect on grade school performance; Barbara Luke, Principal Investigator.

  31. Human Resources Research Organization. Independent evaluation of the validity and reliability of STAAR grades 3-8 assessment scores: Part 2. Final Report. No. 017. Alexandria, VA, 2016.

  32. https://tea.texas.gov/Student_Testing_and_Accountability/Testing/State_of_Texas_Assessments_of_Academic_Readiness

  33. Gu X, Zhang T, Chu TL, Zhang X, Thomas KT. Do physically literate adolescents have better academic performance? Percept Motor Skills. 2019;126(4):585–602.

    PubMed  Article  Google Scholar 

  34. Sahin A, Willson V, Capraro RM. Comparisons of students’ mathematics and reading achievement in Texas: Public versus charter schools. JRSMTE. 2018;1(1):2–28.

    Article  Google Scholar 

  35. Robertson J. The relationship between physical fitness and academic achievement for fourth grade students in southeast Texas. 2017. A Dissertation Presented to The Faculty of the College of Graduate Studies Lamar University

  36. https://tea.texas.gov/Student_testing_and_Accountability/Testing/State_of_Texas_Assessments_of_Academic_Readiness_(STAAR)/Progress_Measures/

  37. Eriksen HL, Kesmodel US, Underbjerg M, Kilburn TR, Bertrand J, Mortensen EL. Predictors of intelligence at the age of 5: Family, pregnancy, and birth characteristics. PLoS ONE. 2013;8:79200.

    Article  Google Scholar 

  38. Ponjaert-Kristoffersen I, Bonduelle M, Barnes J, Nekkebroeck J, Loft A, Wennerholm UB, et al. International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments. Pediatrics. 2005;115:e283–9.

    CAS  PubMed  Article  Google Scholar 

  39. Behrman RE, Butler AS, editors. Preterm birth: causes, consequences, and prevention. Washington, DC: National Academies Press; 2007.

    Google Scholar 

  40. Brooks-Gunn J, Duncan GJ. The effects of poverty on children. Futur Child. 1997;7(2):55–71.

    CAS  Article  Google Scholar 

  41. Duncan GJ, Yeung WJ, Brooks-Gunn J, Smith JR. How much does childhood poverty affect the life chances of children? Am Sociol Rev. 1998;63(3):406.

    Article  Google Scholar 

  42. Richards JL, Chapple-McGruder T, Williams, et al. Does neighborhood deprivation modify the effect of preterm birth on children’s first grade academic performance? Soc Sci Med. 2015;132:122–31.

    PubMed  PubMed Central  Article  Google Scholar 

  43. Lesnick J, Goerge R, Smithgall C, Gwynne J. Reading on grade level in third grade: how is it related to high school performance and college enrollment? Chicago: Chapin Hall at the University of Chicago; 2010.

    Google Scholar 

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Acknowledgements

Special acknowledgement to the Texas Department of State Health Services Center for Health Statistics Data Linking Team who linked SART CORS data to birth certificates, and to the TEA staff who assisted us in this study.

The authors thank the Society for Assisted Reproductive Technology and all of its members for providing clinical information to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for use by patients and researchers. Without the efforts of their members, this research would not have been possible.

Availability of data

The data used in this analysis were obtained from private (SART CORS) and public (TEA test scores) sources, under data use agreements, and confidentiality pledges assuring that the data would not be shared or distributed, and therefore are not available to other investigators.

Funding

This project was supported by grant R01 HD084377 from the National Institute of Child Health and Human Development National Institutes of Health, USA (Barbara Luke, Principal Investigator). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Child Health and Human Development, or the National Institutes of Health, nor any of the State Departments of Health which contributed data.

Author information

Authors and Affiliations

Authors

Contributions

Drs. Luke and Brown had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Luke and Brown

Acquisition, analysis, or interpretation of data: all authors

Drafting of the manuscript: Luke, Brown

Critical revision of the manuscript for important intellectual content: all authors

Statistical analysis: Brown

Obtained funding: Luke, Brown

Administrative, technical, or material support: all authors

Supervision: Luke

Corresponding author

Correspondence to Barbara Luke.

Ethics declarations

Ethics approval

This study was approved by the Institutional Review Boards at Michigan State University, the University of Michigan, and each of the four study State Departments of Health.

Conflict of interest

Drs. Luke and Brown reported receiving grants from NIH during the conduct of the study. Ms. Forestieri, Dr. Yazdy, and Dr. Browne reported receiving NIH grant support from Michigan State University during the conduct of the study. Mr. Wantman reported receiving personal fees from SART, being a data vendor of SART, and maintaining the SART CORS database during the course of the study; and personal fees from NYU Fertility, MyEggBank, Prelude Fertility, Shady Grove Fertility, Northwell Health Fertility, and Mass General Fertility outside the submitted work. No other disclosures were reported.

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Luke, B., Brown, M.B., Ethen, M.K. et al. Sixth grade academic achievement among children conceived with IVF: a population-based study in Texas, USA. J Assist Reprod Genet 38, 1481–1492 (2021). https://doi.org/10.1007/s10815-021-02170-9

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  • DOI: https://doi.org/10.1007/s10815-021-02170-9

Keywords

  • IVF
  • Academic achievement
  • End-of-grade testing