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Establishing a reproductive biorepository for basic and translational research: experience developing the reproductive subjects registry and sample repository

  • Reproductive Physiology and Disease
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To report experience designing and establishing a reproductive registry and sample biorepository and to describe initial subject characteristics and biospecimens.

Methods

Beginning in December 2017, patients presenting for reproductive care at the University of Michigan were approached for study enrollment. Following consent, subjects completed detailed reproductive and health questionnaires. A variety of reproductive specimens and tissues were collected and processed for multiple downstream applications.

Results

Subject enrollment began in December of 2017. There are currently 1798 subjects enrolled. Female participants report a variety of reproductive disorders. Available samples include semen, sperm, follicular fluid, granulosa cells, immature oocytes, ovarian and uterine tissue, and blood samples.

Conclusion

We report the successful establishment of a reproductive registry and sample biorepository. Furthermore, we describe methods for collection and storage of a variety of reproductive tissue processed for multiple downstream translational applications.

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Funding

This work was supported by the University of Michigan Department of Obstetrics & Gynecology. This work was also funded by the National Institutes of Health Grants 5K12HD065257-10 (DF & SBS), 5R01HD088638-03(EEM) & 5R01MD011570-05(EEM).

Author information

Authors and Affiliations

  1. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA

    Samantha B. Schon, Min Xu, Kun Yang, Jayne Reynolds & Erica E. Marsh

  2. Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA

    Nicholas Raja & Heather Cameron

  3. Division of Female Pelvic Medicine & Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA

    Dee Fenner

Authors
  1. Samantha B. Schon
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  2. Nicholas Raja
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  3. Min Xu
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  4. Heather Cameron
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  5. Kun Yang
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  6. Jayne Reynolds
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  7. Dee Fenner
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  8. Erica E. Marsh
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Corresponding author

Correspondence to Samantha B. Schon.

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Ethics approval

The protocols and procedures reported have been approved by the Institutional Review Board of the University of Michigan Medical School (IRBMED), registered under ID HUM00125627.

Conflict of interest

EEM is a consultant for Myovant Sciences. The other authors declare that they have no conflicts of interest.

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Schon, S.B., Raja, N., Xu, M. et al. Establishing a reproductive biorepository for basic and translational research: experience developing the reproductive subjects registry and sample repository. J Assist Reprod Genet 38, 2097–2105 (2021). https://doi.org/10.1007/s10815-021-02165-6

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  • DOI: https://doi.org/10.1007/s10815-021-02165-6

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