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Association of CPT1A gene polymorphism with the risk of gestational diabetes mellitus: a case-control study

  • Genetics
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Abstract

Purpose

Gestational diabetes mellitus (GDM) is a growing public health problem worldwide and its etiology remains unclear. The pathophysiology of GDM is similar to that of type 2 diabetes (T2DM) and insulin resistance (IR) is the main reason for the development of GDM. Carnitine palmitoyltransferase 1A (CPT1A) is a candidate gene for metabolic disorders; however, the association of the CPT1A gene and GDM has not yet been studied. We aimed to explore whether single-nucleotide polymorphisms (SNPs) of the CPT1A gene could influence the risk of GDM.

Methods

We examined 18 single-nucleotide polymorphisms (SNPs) in the CPT1A gene and the risk of GDM in a nested case-control study of 334 GDM patients and 334 controls. The controls who had no GDM were randomly selected through matching to cases by age and residence.

Results

After adjusting the family history of diabetes, pre-pregnancy body mass index, and multiple comparison correction, the CPT1A rs2846194 and rs2602814 were associated with reduced GDM risk while rs59506005 was associated with elevated GDM risk. Moreover, the GGAC haplotype in the CPT1A gene (rs17399246 rs1016873 rs11228450 rs10896396) was associated with a reduced risk of GDM.

Conclusion

Our study provides evidence for an association between genetic polymorphisms in the CPT1A and the risk of GDM.

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Data Availability

The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Code availability

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Acknowledgements

The authors express their appreciation to the participants in the Taiyuan Birth Cohort Study for their enthusiastic support.

Funding

This study was funded by the National Natural Science Foundation of China (81703314) and the Scientific and Technological Innovation Project of Higher Education Institutions in Shanxi Province (2019L0439).

Author information

Authors and Affiliations

  1. Department of Epidemiology, Shanxi Medical University School of Public Health, Center of Clinical Epidemiology and Evidence-Based Medicine, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China

    Qingwen Ren, Mengzhu Guo, Feifei Yang, Tianbi Han, Wenqiong Du, Feng Zhao, Jinbo Li, Wangjun Li, Yongliang Feng, Suping Wang & Weiwei Wu

  2. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Yawei Zhang

Authors
  1. Qingwen Ren
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Contributions

All authors contributed to the study’s conception and design. Material preparation was performed by Feifei Yang, Tianbi Han, Wenqiong Du, and Feng Zhao. Data collection and analysis were performed by Qingwen Ren, Mengzhu Guo, Jinbo Li, and Wangjun Li. Yongliang Feng was responsible for grammar editing. Suping Wang, Yawei Zhang, and Weiwei Wu were in charge of study supervision. The first draft of the manuscript was written by Qingwen Ren and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Weiwei Wu.

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Ethics approval

All study procedures were approved by the Human Investigation Committee at the Shanxi Medical University.

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Informed consent to inclusion in the study was obtained from all individual participants included in the study.

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Patients signed informed consent regarding publishing their data and photographs.

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The authors declare no competing interests.

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Cite this article

Ren, Q., Guo, M., Yang, F. et al. Association of CPT1A gene polymorphism with the risk of gestational diabetes mellitus: a case-control study. J Assist Reprod Genet 38, 1861–1869 (2021). https://doi.org/10.1007/s10815-021-02143-y

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  • DOI: https://doi.org/10.1007/s10815-021-02143-y

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