Abstract
Purpose
Does IDEF mapping help monitor the technical process of IUI and explore the potential improvements which might contribute to increased pregnancy and live birth rates?
Method
Retrospective analysis of 1729 homologous IUI cycles of couples attending a fertility clinic in a university hospital setting. Standardized conventional semen parameters were analyzed and the semen samples prepared via discontinuous density gradient centrifugation.
Results
There was no significant association between sperm concentration, motility and morphology (analysis phase), and pregnancy outcome. Only female and male ages were significantly associated with the pregnancy outcome. There was a significant difference in the odds on clinical pregnancies and live births when analysis was ≤ 21 min initiated, and < 107 min between sample production and IUI, adjusted for male and female age.
Conclusions
Adjusting for the couple’s age, we could show that time intervals between semen production and analysis and IUI when kept low significantly influenced clinical pregnancies and live births.
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Acknowledgments
The authors acknowledge Luc Delbeke (past Medical Director, Centre for Reproductive Medicine) and Tina Schiltz, Christine Croes, Els Smet, and Zehra Kara for preparing the semen samples.
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U.P. substantially contributed to the conception and design, acquisition of data, analysis and interpretation of data, drafting the article, revising it critically for important intellectual content, and final approval of the version to be published. D.D.N. substantially contributed to the conception, acquisition of data, interpretation of data, revising it critically for important intellectual content, and final approval of the version to be published. E.R. was involved in statistical analysis and interpretation of data, revising it critically for important intellectual content, and final approval of the version to be published. All the other authors conducted additional data acquisition, critical revision of the article, and approved the final version of the manuscript.
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Punjabi, U., Van Mulders, H., Van de Velde, L. et al. Time intervals between semen production, initiation of analysis, and IUI significantly influence clinical pregnancies and live births. J Assist Reprod Genet 38, 421–428 (2021). https://doi.org/10.1007/s10815-020-02020-0
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DOI: https://doi.org/10.1007/s10815-020-02020-0