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Length of ovarian stimulation does not impact live birth rate in fresh donor oocyte cycles: a SART CORS study

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Abstract

Purpose

To evaluate the effect of controlled ovarian hyperstimulation length and total gonadotropin (GN) dose on recipient live birth rate (LBR) in fresh donor oocyte cycles.

Methods

Data was obtained from SART CORS on all fresh donor oocyte GnRH antagonist cycles (n = 1049) between 2014 and 2015 which resulted in a single embryo transferred. Donor and recipient demographic information and cycle characteristics were extracted. Binomial regression was used to estimate LBR with respect to days of stimulation (DOS) and total GN dose. Multivariate analysis was performed to evaluate these relationships after controlling for confounders.

Results

Overall LBR in fresh donor oocyte cycles was 57%. Average stimulation length was 14.3 ± 4.9 days, and total GN dose was 2464 ± 1062 IU. On univariate analysis, neither days of stimulation (p = 0.5) nor total GN dose (p = 0.57) was independently correlated with LBR. However, in prolonged stimulations (> 15 days) with high total GN dose (> 3000 IU), as both the cycle length and total GN dose increased, LBR significantly decreased from 63.81 to 48.15% (p = 0.02) and from 67.61 to 48.15% (p = 0.01), respectively. Multivariate analysis showed no significant effect of either DOS or total GN dose on LBR.

Conclusions

LBR is significantly decreased in fresh donor oocyte cycles when cycles are prolonged with high total GN dose. However, after controlling for confounders neither DOS nor total GN dose significantly affects LBR.

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Acknowledgments

SART wishes to thank all of its members for providing clinical information to the SART CORS database for use by patients and researchers. Without the efforts of our members, this research would not have been possible.

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Authors and Affiliations

Authors

Contributions

All authors contributed to the study conception and data collection. Data analysis was performed by Melissa Fazzari. The first draft of the manuscript was written by Alexa Cohen, Michelle Kappy, and Rachel Gerber, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Erkan Buyuk.

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Conflict of interest

Erkan Buyuk, MD is a consultant for EMD-Serono. Other authors report no conflict of interest.

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SART-CORS database.

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Cohen, A., Kappy, M., Fazzari, M. et al. Length of ovarian stimulation does not impact live birth rate in fresh donor oocyte cycles: a SART CORS study. J Assist Reprod Genet 37, 3033–3038 (2020). https://doi.org/10.1007/s10815-020-01972-7

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  • DOI: https://doi.org/10.1007/s10815-020-01972-7

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