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What is the clinical impact of the endometrial receptivity array in PGT-A and oocyte donation cycles?

  • Assisted Reproduction Technologies
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To evaluate the influence of the endometrial receptivity array (ERA) test on the implantation rate (IR) and pregnancy rate (PR) in patients with previous failed euploid embryo transfers (Euploid-ET) or oocyte donation embryo transfers (Donor-ET).


Single-center retrospective study of patients with ≥ 1 previous failed Euploi-ET (n = 24) or ≥ 2 failed Donor-ET (n = 32) who underwent an ERA test and a post-ERA Euploid-ET/Donor-ET between 2012 and 2018. Controls were patients with ≥ 1 previously failed Euploid-ET (n = 119) or ≥ 2 failed Donor-ET (n = 158) who underwent Euploid-ET/Donor-ET during the same period without performing an ERA test. Only blastocyst stage embryos were included. IR/PR was compared between the post-ERA ET and the last ET in the control group.


There was no statistically significant difference regarding IR [55.6% (34.6–76.5%) vs. 65.0% (56.9–73.1%)] nor PR (58.3% vs.70.6%, p = 0.238) in the Euploid-ET ERA vs. Euploid-ET control groups. In the Donor-ET arm, both IR [26.8% (12.3–41.4%) vs. 57.2% (50.1–64.3%)] and PR (34.4% vs. 65.2%, p = 0.001) were significantly lower in the ERA group. Multivariate analysis confirmed that performing an ERA test did not influence the PR in the Euploid-ET arm and was associated with a diminished PR in the Donor-ET arm. In the ERA group, 41.1% patients were non-receptive (NR). No significant difference was found regarding IR/PR in NR vs. receptive patients in both Euploid-ET/Donor-ET arms.


In our sample, the performance of an ERA test did not improve pregnancy outcomes. Future prospective studies in larger samples are needed to confirm the role of the ERA test in Euploid-ET/Donor-ET.

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This work was performed under the auspices of the Cátedra de Investigació en Obstetrícia I Ginecologia of the Department of Obstetrics, Gynaecology and Reproduction, Dexeus University Hospital, Universitat Autònoma de Barcelona.

Competing interests

The authors declare that they have no competing interests.

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Authors and Affiliations



ARN designed the study, performed the literature search, wrote the manuscript, and constructed the tables and figures. MD, FM, NP, and BC contributed to the design of the research study, edited the manuscript, and provided critical review of the manuscript. SGM and IR contributed to data collection and statistical analysis. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ana Raquel Neves.

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The study was performed in accordance with the Helsinki Declaration and with approval of the Institutional Review Board. Because the study involved completely de-identified data extraction from electronic medical records, patient consent was not required.

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Neves, A.R., Devesa, M., Martínez, F. et al. What is the clinical impact of the endometrial receptivity array in PGT-A and oocyte donation cycles?. J Assist Reprod Genet 36, 1901–1908 (2019).

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