Skip to main content
Log in

A successful treatment with 5 methyltetrahydrofolate of a 677 TT MTHFR woman suffering premature ovarian insufficiency post a NHL (non-Hodgkin’s lymphoma) and RPL (repeat pregnancy losses)

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Gong M, Deng W, He T, Shi Z, Huang G, et al. MTHFR 677C>T polymorphism increases the male infertility risk: a meta-analysis involving 26 studies. PLoS One. 2015;10(3):e0121147.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Enciso M, Sarasa J, Xanthopoulou L, Bristow S, Bowles M, Fragouli E, et al. Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy. Hum Genet. 2016;135:555–68.

    Article  CAS  PubMed  Google Scholar 

  3. van der Put NMJ, Blom HJ. Neural tube defects and a disturbed folate dependent homocysteine metabolism. Eur J Obstet Gynecol Reprod Biol. 2000;92:57–61.

    Article  PubMed  Google Scholar 

  4. Serman L, Dodig D. Impact of DNA methylation on trophoblast function. Clin Epigenetics. 2011;3:7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Branco MR, King M, Perez-Garda V, Bogutz AB, Caley M, et al. Maternal DNA methylation regulates early trophoblast development. Dev Cell. 2016;36:152–63.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Unfried G, Griesmacher A, Weismüller W, Nagele F, Huber JC, Tempfer CB. The C677T polymorphism of the methylenetetrahydrofolate reductase gene and idiopathic recurrent miscarriage. Obstet Gynecol. 2002;99:614–9.

    CAS  PubMed  Google Scholar 

  7. Yang Y, Luo Y, Yuan J, Tang Y, Xiong L, Xu MM, et al. Association between maternal, fetal and paternal MTHFR gene C677T and A1298C polymorphisms and risk of recurrent pregnancy loss: a comprehensive evaluation. Arch Gynecol Obstet. 2016;293:1197–211.

    Article  CAS  PubMed  Google Scholar 

  8. He J, Liao XY, Zhu JH, Xue WO, Shen GP, et al. Association of MTHFR C577T and A1298C polymorphisms with non-Hodgkin lymphoma susceptibility: evidence from a meta-analysis. Sci Rep. 2014;4:6159.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Bailey SW, Ayling JE. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proc Natl Acad Sci U S A. 2009;106:15424–9.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Dattilo M, D Amato G, Caroppo E, Ménézo Y. Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet. J Assist Reprod Genet. 2016;33:1633–48.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Servy EJ, Jacquesson-Fournols L, Cohen M, Menezo YJR. MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series. J Assist Reprod Genet. 2018.

  12. Jacquesson-Fournols L, Servy EJ, Dale B, Clement A, Menezo Y. MTHFR testing in ART should be compulsory in both male and female patients including oocyte donation programs. J Gynecol Women’s Health. 2017 MS Id 555706.

  13. Silvestris E, Cohen M, Cornet D, Jacquesson-Fournols L, Clement P, Chouteau J, et al. Supporting the one-carbon cycle restores ovarian Reserve in Subfertile Women: absence of correlation with urinary bisphenol a concentration. Biores Open Access. 2017;6:104–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Cornet D, Clement A, Clement P, Menezo Y. High doses of folic acid induce a pseudo MTHFR syndrome in a wild type patient: a case report. Sage Open Med Case Rep. 2018.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yves J. R. Menezo.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Goyco Ortiz, L.E., Servy, E.J. & Menezo, Y.J.R. A successful treatment with 5 methyltetrahydrofolate of a 677 TT MTHFR woman suffering premature ovarian insufficiency post a NHL (non-Hodgkin’s lymphoma) and RPL (repeat pregnancy losses). J Assist Reprod Genet 36, 65–67 (2019). https://doi.org/10.1007/s10815-018-1332-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10815-018-1332-0

Navigation