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In vitro maturation (IVM) of oocytes in patients with resistant ovary syndrome and in patients with repeated deficient oocyte maturation

Journal of Assisted Reproduction and Genetics volume 35, pages 2161–2171 (2018)Cite this article

Abstract

Purpose

To assess the efficiency of IVM in patients with repeated ART failure due to resistant ovary syndrome or due to deficient oocyte maturation.

Methods

Clinical and laboratory data were obtained retrospectively from 28 patients who underwent 49 cycles of IVM between 2010 and 2017; nine patients had resistant ovary syndrome and 19 patients had repeated deficient oocyte maturation.

Results

Nine patients with resistant ovary syndrome underwent 24 IVM cycles. In those, an average of 11.5 ± 10.4 cumulus-oocyte complexes (COC) was retrieved, and IVM resulted in 3.4 ± 3.1 mature oocytes. After ICSI and transfer of 23 cleavage-stage embryos, eight pregnancies were obtained, resulting in five healthy live births. The live birth rate was 16.7% per started cycle and 33.3% per patient.

Nineteen patients with a history of deficient oocyte maturation underwent 25 IVM cycles. An average of 10.6 ± 9.2 COC was retrieved, and after IVM, 1.3 ± 2.1 oocytes were mature. No mature oocytes were obtained in 11 cycles. In ten cycles with mature oocytes, none of them fertilized after ICSI. Out of four cycles with fertilized oocytes, only one good-quality embryo was obtained. No live births were obtained after IVM in patients with a history of deficient oocyte maturation.

Conclusions

Based on our experience, IVM is a valuable approach in patients with resistant ovary syndrome, but should not be recommended for patients with deficient oocyte maturation.

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Author information

Affiliations

  1. Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium

    A Galvão, I Segers, H Tournaye & Michel De Vos

  2. Centro Materno Infantil do Norte, Centro Hospitalar do Porto, Porto, Portugal

    A Galvão

  3. Laboratory of Clinical Chemistry and Radioimmunology, UZ Brussel, Brussels, Belgium

    J Smitz

Authors
  1. A Galvão
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  2. I Segers
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  3. J Smitz
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  4. H Tournaye
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  5. Michel De Vos
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Corresponding author

Correspondence to Michel De Vos.

Ethics declarations

The study was approved by the hospital Institutional Review Board (IRB) - B.U.N. 143201835921.

Conflict of interest

A.G., I.S., and J.S. have no conflict of interest. M.D.V. received honoraria for lectures from MSD, Cook Medical, Besins, and Ferring and he is the principal investigator of a research program funded by the FWO Board and the Board of Trustees of the F.R.S.-FNRS (application no. 30443682 submitted as part of the “Excellence of Science - EOS” Call 2017). H.T. reports grants from Cook, during the conduct of the study; grants from Merck Serono; grants from MSD; grants from Goodlife; grants from Roche; grants from Besins; other from Finox; other from Abbott; other from ObsEva, grants from Ferring; grants from Research Fund of Flanders (FWO); and grants from Ferring, outside the submitted work.

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Galvão, A., Segers, I., Smitz, J. et al. In vitro maturation (IVM) of oocytes in patients with resistant ovary syndrome and in patients with repeated deficient oocyte maturation. J Assist Reprod Genet 35, 2161–2171 (2018). https://doi.org/10.1007/s10815-018-1317-z

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  • DOI: https://doi.org/10.1007/s10815-018-1317-z

Keywords

  • In vitro maturation
  • Deficient oocyte maturation
  • Resistant ovary syndrome