Skip to main content
SpringerLink
Log in

Endometriosis does not affect live birth rates of patients submitted to assisted reproduction techniques: analysis of the Latin American Network Registry database from 1995 to 2011

  • Reproductive Physiology and Disease
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study is to compare the results of ART treatment in patients with and without endometriosis in a large cohort of patients from different centers over an extented period of time.

Methods

This retrospective study is using data from patients undergoing 27,294 cycles of IVF/ICSI treatment between 1995 and 2011 that were registered in the database of the Latin American Registry maintained by the Latin America Network of Assisted Reproduction.

Results

The mean number of retrieved oocytes was higher in the control group, but the mean number of metaphase II oocytes was similar. Fertilization rate and transfer rate were higher in the control group. We observed higher pregnancy rates, per cycle initiated and per embryo transfer and higher live birth rate in the endometriosis group. In the group of patients with 25–35 years old, the number of oocytes, fertilization rate, and number of transferred embryos were significantly higher in the control group. However, pregnancy rate and live birth rate were higher in the endometriosis group. In the group of patients with 36–40 years old, the number of transferred embryos was higher in the control group, but the pregnancy rate and live birth rate were higher in the endometriosis group. In the group of patients with 41 to 42 years old, the number of transferred embryos and the transfer rate were higher in the control group, but the pregnancy rate was higher in the endometriosis group.

Conclusion

Our results demonstrate that endometriosis does not affect the outcome of patients subjected to IVF/ICSI and although patients with endometriosis present lower number of oocytes and higher cancelation rate, these shortcomings do not reduce pregnancy and live birth rates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Kennedy S, Bergqvist A, Chapron C, D’Hooghe T, Dunselman G, Greb R, et al. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod. 2005;20:2698–704.

    Article  PubMed  Google Scholar 

  2. Johnson NP, Hummelshoj L, for The World Endometriosis Society Montpellier Consortium. Consensus on current management of endometriosis. Hum Reprod. 2013;28:1552–68.

    Article  PubMed  Google Scholar 

  3. Adamson GD, Kennedy SH, Hummelshoj L. Creating solutions in endometriosis: global collaboration through the World Endometriosis Research Foundation. J Endometr. 2010;2:3–6.

    Article  Google Scholar 

  4. Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am. 2012;39:535–49.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Dmowski WP, Pry M, Ding J, Rana N. Cycle-specific and cumulative fecundity in patients with endometriosis who are undergoing controlled ovarian hyperstimulation-intrauterine insemination or in vitro fertilization-embryo transfer. Fertil Steril. 2002;78:750–6.

    Article  PubMed  Google Scholar 

  6. Ozkan S, Arici A. Advances in treatment options of endometriosis. Gynecol Obstet Investig. 2009;67:81–91.

    Article  CAS  Google Scholar 

  7. Simón C, Gutiérrez A, Vidal A, de los Santos MJ, Tarín JJ, Remohí J, et al. Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod. 1994;9:725–9.

    Article  PubMed  Google Scholar 

  8. Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization. Fertil Steril. 2002;77:1148–55.

    Article  PubMed  Google Scholar 

  9. Coccia ME, Rizzello F, Mariani G, Bulletti C, Palagiano A, Scarselli G. Impact of endometriosis on in vitro fertilization and embryo transfer cycles in young women: a stage-dependent interference. Acta Obstet Gynecol Scand. 2011;90:1232–8.

    Article  PubMed  Google Scholar 

  10. Harb HM, Gallos ID, Chu J, Harb M, Coomarasamy A. The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis. BJOG. 2013;120:1308–20.

    Article  PubMed  CAS  Google Scholar 

  11. Rossi AC, Prefumo F. The effects of surgery for endometriosis on pregnancy outcomes following in vitro fertilization and embryo transfer: a systematic review and meta-analysis. Arch Gynecol Obstet. 2016;294:647–55.

    Article  PubMed  Google Scholar 

  12. Bérubé S, Marcoux S, Langevin M, Maheux R. Fecundity of infertile women with minimal or mild endometriosis and women with unexplained infertility. The Canadian Collaborative Group on Endometriosis Fertil Steril 1998;69:1034–1041.

  13. Geber S, Paraschos T, Atkinson G, Margara R, Winston RM. Results of IVF in patients with endometriosis: the severity of the disease does not affect outcome, or the incidence of miscarriage. Hum Reprod. 1995;10:1507–11.

    Article  PubMed  CAS  Google Scholar 

  14. Matalliotakis IM, Cakmak H, Mahutte N, Fragouli Y, Arici A, Sakkas D. Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertil Steril. 2007;88:1568–72.

    Article  PubMed  CAS  Google Scholar 

  15. de Ziegler D, Gayet V, Aubriot FX, Fauque P, Streuli I, Wolf JP, et al. Use of oral contraceptives in women with endometriosis before assisted reproduction treatment improves outcomes. Fertil Steril. 2010;94:2796–9.

    Article  PubMed  Google Scholar 

  16. Opoien HK, Fedorcsak P, Omland AK, Abyholm T, Bjercke S, Ertzeid G, et al. In vitro fertilization is a successful treatment in endometriosis-associated infertility. Fertil Steril. 2012;97:912–8.

    Article  PubMed  Google Scholar 

  17. Hamdan M, Omar SZ, Dunselman G, Cheong Y. Influence of endometriosis on assisted reproductive technology outcomes: a systematic review and meta-analysis. Obstet Gynecol. 2015;125:79–88.

    Article  PubMed  Google Scholar 

  18. Kawwass JF, Crawford S, Session DR, Kissin DM, Jamieson DJ, National ART Surveillance System Group. Endometriosis and assisted reproductive technology: United States trends and outcomes 2000-2011. Fertil Steril. 2015;103:1537–43.

    Article  PubMed  Google Scholar 

  19. Senapati S, Sammel MD, Morse C, Barnhart KT. Impact of endometriosis on in vitro fertilization outcomes: an evaluation of the Society for Assisted Reproductive Technologies Database. Fertil Steril. 2016;106:164–71.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Lin XN, Wei ML, Tong XM, Xu WH, Zhou F, Huang QX, et al. Outcome of in vitro fertilization in endometriosis-associated infertility: a 5-year database cohort study. Chin Med J. 2012;125:2688–93.

    PubMed  CAS  Google Scholar 

  21. Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, et al. The international glossary on infertility and fertility care. Hum Reprod. 2017;32:1786–801.

    Article  PubMed  PubMed Central  Google Scholar 

  22. González-Comadran M, Schwarze JE, Zegers-Hochschild F, Souza MD, Carreras R, Checa MÁ. The impact of endometriosis on the outcome of assisted reproductive technology. Reprod Biol Endocrinol. 2017;15:8–15.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clínica NeoVitae/ORIGEN, Governador Valadares, Brazil

    Mário Murta & Roberto Carlos Machado

  2. Maaster Internacional Medicina Reproductiva, Hospital del Mar, Barcelona, Spain

    Mário Murta

  3. The Latin American Registry of ART, Montevideo, Uruguay

    Fernando Zegers-Hochschild

  4. Unit of Reproductive Medicine, Clinica las Condes, and Program of Ethics and Public Policies in Human Reproduction University Diego Portales, Santiago, Chile

    Fernando Zegers-Hochschild

  5. Universitat Autònoma de Barcelona, Barcelona, Spain

    Miguel Angel Checa

  6. Department of Obstetrics and Gynecology, Parc de Salut Mar, Universitat Autonoma de Barcelona, Barcelona, Spain

    Miguel Angel Checa

  7. ORIGEN, Center for Reproductive Medicine, Belo Horizonte, Brazil

    Marcos Sampaio & Selmo Geber

  8. Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    Selmo Geber

  9. Belo Horizonte, Brazil

    Selmo Geber

Authors
  1. Mário Murta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roberto Carlos Machado
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fernando Zegers-Hochschild
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Miguel Angel Checa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Marcos Sampaio
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Selmo Geber
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Selmo Geber.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Murta, M., Machado, R.C., Zegers-Hochschild, F. et al. Endometriosis does not affect live birth rates of patients submitted to assisted reproduction techniques: analysis of the Latin American Network Registry database from 1995 to 2011. J Assist Reprod Genet 35, 1395–1399 (2018). https://doi.org/10.1007/s10815-018-1214-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10815-018-1214-5

Keywords

Search

Navigation